Physical Education
soudabeh rezaei; Neda Khaledi
Volume 28, Issue 5 , November and December 2021, , Pages 688-699
Abstract
Introduction: Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on ...
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Introduction: Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on FOXO1 gene expression in the hippocampus and level of serum TNF-α in male Wistar diabetic rats.Materials and Methods: For this study, 48 male Wistar rats (4 weeks old) with 150±10 g weight were categorized in 4 groups of (n=12): diabetic rats, exercise diabetic, control and exercise control. For induction of diabetes, peritoneal injection of STZ solution (50 mg/kg) was used. After a week of familiarization with the environment and practice, HIIT protocol consisted of 3 days per week for 6 weeks with 50% to 110% of maximum oxygen consumption was performed. 24 hours after the completion of the exercise, the functional test was taken and the animals were autopsy 48 hours after the functional test. FOXO1 gene expression was evaluated using Real Time PCR technique.Results: Regarding the results, HIIT significantly decreased FOXO1 gene expression in training groups (P≤0.01). Also, TNF-α protein decreased significantly (P≤0/05). Weight gain of the hippocampus was associated with a reduction in the FOXO1 gene in the diabetic training group.Conclusion: HIIT probably reduce the weight loss of the hippocampal tissue that caused by diabetes, by reducing the FOXO1 apoptotic and inflammatory factors of TNF-α.
Physical Education
Mohammad Ali Gharaat; Majid Kashef; Leila Eidi Abarghani; Mohsen Sheykhlouvand
Volume 27, Issue 1 , May and June 2020, , Pages 73-81
Abstract
Scope: According to the role of beta-alanine in buffering, this study aimed to investigate the effects of chronic beta-alanine ingestion on rowing performance.Materials & Methods: Twenty-four elite male rowers (age:23.4 ±3.3 years, height: 186.1± 7.9 cm, body fat percentage: 8.9 ± ...
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Scope: According to the role of beta-alanine in buffering, this study aimed to investigate the effects of chronic beta-alanine ingestion on rowing performance.Materials & Methods: Twenty-four elite male rowers (age:23.4 ±3.3 years, height: 186.1± 7.9 cm, body fat percentage: 8.9 ± 2.1) randomly divided into beta-alanine (40 milligrams. Kilogram-1 body weight per day), placebo (dextrose) or no-supplement for 21 days (n=8). After evaluating Volume of O2 maximum (VO2max) and velocity in VO2max (vVO2max), test of 6 min rowing ergometer for assessing mean power output, mean velocity in 6 minutes rowing maximum (vRmax) and Time at vRmax (TvRmax), and test of 6min ergo rowing with 90% of vRmax were executed in a pre- posttest procedure Power output (P), time to exhaustion (TvRmax), lactate concentration (LA) and heart rate (HR) were recorded from ergo rowing. For analysisng the outputs, ANOVA was utilized. Findings: Significant differences were shown in power output in 6 min@24str, vRmax (p= 0.00), TvRmax and LA in Post-test between beta-alanine and placebo or control (P= 0.00 and P= 0.04 respectively). Conclusion: It can be concluded that ingesting beta-alanine might delay lactate accumulation and increases time to exhaustion in rowing performance.