Physical Education
soudabeh rezaei; Neda Khaledi
Volume 28, Issue 5 , November and December 2021, , Pages 688-699
Abstract
Introduction: Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on ...
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Introduction: Increasing the expression of FOXO1 gen in hippocampus as well as inflammatory factor of TNF-α in diabetic individual's causes the expression of genes involved in apoptosis and disrupts its performance. The aim of the present study was investigation of the effect of 6-weeks HIIT on FOXO1 gene expression in the hippocampus and level of serum TNF-α in male Wistar diabetic rats.Materials and Methods: For this study, 48 male Wistar rats (4 weeks old) with 150±10 g weight were categorized in 4 groups of (n=12): diabetic rats, exercise diabetic, control and exercise control. For induction of diabetes, peritoneal injection of STZ solution (50 mg/kg) was used. After a week of familiarization with the environment and practice, HIIT protocol consisted of 3 days per week for 6 weeks with 50% to 110% of maximum oxygen consumption was performed. 24 hours after the completion of the exercise, the functional test was taken and the animals were autopsy 48 hours after the functional test. FOXO1 gene expression was evaluated using Real Time PCR technique.Results: Regarding the results, HIIT significantly decreased FOXO1 gene expression in training groups (P≤0.01). Also, TNF-α protein decreased significantly (P≤0/05). Weight gain of the hippocampus was associated with a reduction in the FOXO1 gene in the diabetic training group.Conclusion: HIIT probably reduce the weight loss of the hippocampal tissue that caused by diabetes, by reducing the FOXO1 apoptotic and inflammatory factors of TNF-α.
Physical Education
mehdi yadegari; Simin Riahy; Shadmehr Mirdar; Gholamreza Hamidian
Volume 26, Issue 3 , September and October 2019, , Pages 393-402
Abstract
Background: This study investigated the effect of 3-weeks Taper in hypoxic environment on the ratio of Bax / Bcl2 and alveolar epithelial cells populations in the lung.Materials and Methods: Thirty-five rats (4 weeks old, weighing 8 ± 72 g) were divided in five groups: control (6 weeks), training ...
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Background: This study investigated the effect of 3-weeks Taper in hypoxic environment on the ratio of Bax / Bcl2 and alveolar epithelial cells populations in the lung.Materials and Methods: Thirty-five rats (4 weeks old, weighing 8 ± 72 g) were divided in five groups: control (6 weeks), training (6 weeks), hypoxia (3 weeks), hypoxia - taper (3 weeks) and control (9 weeks). Samples entered to the hypoxia after six weeks of interval training and lived there for 3 weeks. another group with exposure to hypoxic environment , implementation Taper technique.Bax/Bcl2 ratio of lung measured by immunohistochemistry and type II and type I pneumocytes population of pulmonary alveolar measured with stereologically.Results: Bax/Bcl2 ratio and type II pneumocytes population Increased and type I pneumocytes population Decreased After six weeks high intensity interval training (P≤0.5).Bax/Bcl2 ratio and type I pneumocytes population of hypoxia group decreased compared with training group (P≤0.5). three weeks taper in hypoxia group, Led to decrease of Bax/Bcl2 ratio , type II population pneumocytes and Increase of type I pneumocytes (P≤0.5).Conclusion: It seems high intensity interval training and subsequent hypoxia can increase pulmonary alveolar apoptosis. also appears taper is a Efficient Method to decrease of apoptosis lung.