Physical Education
fatemhe parsifar; Majid Vahidian-Rezazadeh; Mohsen Saravani; Hossien Nakhaie
Abstract
Introduction: Alzheimer's disease is the most common form of dementia, which is a fatal neurological disorder. The purpose of this study was to investigate the effect of eight weeks of endurance training and Ginkgo biloba supplementation on the neurotrophic factor derived (BDNF) level from the hippocampus ...
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Introduction: Alzheimer's disease is the most common form of dementia, which is a fatal neurological disorder. The purpose of this study was to investigate the effect of eight weeks of endurance training and Ginkgo biloba supplementation on the neurotrophic factor derived (BDNF) level from the hippocampus brain in the Alzheimer's experimental model.
Materials and Methods: This research was of laboratory type. 50 male Wistar rats weighing 250±20 grams were prepared and divided into seven groups including healthy control, Alzheimer's control, intermittent endurance exercise, Ginkgobiloba supplement, Ginkgobiloba supplement+exercise, shock Surgery, and placebo. To induce Alzheimer's disease in the patient groups, amyloid-beta solution was injected into both sides of the ventricles of the rats' brains. For eight weeks, the exercise groups ran on a treadmill 5 days a week, and the supplemented groups received Ginkgo biloba solution. 24 hours after the last exercise session, the hippocampus tissue was extracted and the BDNF protein level was measured using ELISA method.SPSS software version 22 was used to analyze the data at a significant level (P<0.05).
Results: In the comparison between the groups, the level of BDNF factor was higher in the training+supplement group than in the healthy control, Alzheimer's control, surgical shock, and placebo groups, no increase was observed in the training and supplement alone groups, and the level of the factor was also decreased in the surgical shock and placebo groups.
Conclusion: Intermittent endurance exercise and Ginkgo Biloba supplement consumption at the same time can be an effective treatment to increase the level of BDNF to slow down the process of Alzheimer's disease.
Physical Education
hasan parsa shkooh; Marziyeh Saghebjoo; Samad Nazemi; Mehdi Hedayati
Volume 25, Issue 5 , November and December 2018, , Pages 669-677
Abstract
The physical activity as a therapeutic tool is rapidly growing in the diabetic neuropathy. The aim of this study was to evaluate the effect of six weeks endurance training on the; superoxide dismutase (SOD), catalase (CAT), and pain in sensoty roots of spinal cord of rats with diabetic neuropathy. fourty ...
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The physical activity as a therapeutic tool is rapidly growing in the diabetic neuropathy. The aim of this study was to evaluate the effect of six weeks endurance training on the; superoxide dismutase (SOD), catalase (CAT), and pain in sensoty roots of spinal cord of rats with diabetic neuropathy. fourty rats (10 w; 230- 260 g) were study sample. Thirty rats, received interperitoneal injection of Sterptozotocin (STZ) solution (45 mg/kg, pH=4.5). Rats ranodmly assigned to three groups: diabetic continous training, diabetic interval training, diabetic control. ten rats were assigned in healthy control group. Training protocol was a six weeks aerobic training with 60- 70% VO2max treadmill run. 48 h after the last training session, the sensory part of spinal cord sampled. Data Analysed with Oneway Analysis of variance test (P