Physiology & Pharmacology
mozhgan asghari; goudarz sadeghihashjin; aliakbar golabchifar; mohamad kazem koohi; ahad mohamadnejad; sanaz rismanchi; mohamad taheri
Volume 29, Issue 4 , September and October 2022, , Pages 502-516
Abstract
Introduction: In this study, we investigate the relationship between cancer and exposure to toxic substances in the environment. We used human encounters with them.Materials and Methods: In this experimental study, 60 adult male mice were divided into four groups, including control, Malathion, Malathion ...
Read More
Introduction: In this study, we investigate the relationship between cancer and exposure to toxic substances in the environment. We used human encounters with them.Materials and Methods: In this experimental study, 60 adult male mice were divided into four groups, including control, Malathion, Malathion with benzene and benzene. The control group was tested only with physiological serum. Except for the benzene group, all other groups were in skin contact with Malathion for 45 days was fed. After necropsy, tissue samples were taken from the target organs. In addition, cytotoxicity was assessed by MTT and micronucleus tests in vitro and the percentage of IC50 was determined. Microscopic observations of liver tissue showed hepatotoxicity and renal tissue renal toxicity in the Malathion group with benzene.Results: The percentage of frequency of micronuclei at concentrations of 100 /g / ml, 50 /g / ml, 25 /g / ml was significant in all groups compared to the control group (P <0.05). In MTT test, the percentage of cell growth inhibition at concentrations of 100 g/ml, 50 g/ml, 25 g/ml, and 10 µg/ml in all groups was significantly different from the percentage of inhibition of cell growth with the control group (P < 0.05).Conclusion: According to the findings of this study, certain doses of Malathion alone and in combination with benzene cause cytotoxicity and pre-carcinogenicity in cytotoxicity tests. Malathion exacerbates the carcinogenic effects of benzene
Gholamreza Moussavi; Ahamd Allahabadi; Milad Ganbary; Morteza Dab; Fahimeh Mircholi
Volume 23, Issue 4 , September and October 2016, , Pages 652-661
Abstract
Background Malathion is a pesticide with the highest consumption in phosphoric pesticides. This pesticide has acute and chronic effects. Therefore, for the protection of the water and human health against the harmful effects of these compounds, they must be removed by appropriate treatment of wastewater ...
Read More
Background Malathion is a pesticide with the highest consumption in phosphoric pesticides. This pesticide has acute and chronic effects. Therefore, for the protection of the water and human health against the harmful effects of these compounds, they must be removed by appropriate treatment of wastewater and water resources. Among the treatment methods, the ozonation process has drawn more attention; one of the best options of ozonation process is the catalytic ozonation process (COP)with activated carbon.Materials & Methods In this study, at first the synthetic wastewater was prepared at the mentioned concentration with pure malathion. Then, removal malathion experiments in a cylindrical pilot with a total volume of 200 mL were performed by single ozonation and catalytic ozonation process with use of NH4Cl-induced activated carbon (NAC) obtained from of agricultural waste. Study variables included pH, contact time, the concentration of ozone, and the concentration of catalyst. In all conditions, the sole catalytic ozonation adsorption and catalystic synergistic effects were evaluated.Results The results showed that the removal efficiency of ozone in alkaline pH is higher. Also, in 200 mL samples containing 50 mg/L malathion and 0.1 g/L concentration of catalyst in carbon NAC, in the COP test for 50 minutes, the malathion removal performance was 62.9% in ozonation; 100% in catalytic ozonation, 22% in adsorbtion only, and 15.1% in the synergism effect. It showed the high removal efficiency of COP/NAC.