Physical Education
Mehdi Zarei; Rahim Golmohammadi; Elham Iziy; Seyed Mehdi Beheshti Nasr
Volume 28, Issue 2 , May and June 2021, , Pages 165-172
Abstract
Introduction: There has been no report on the effect of epilepsy on liver enzymes and lipoproteins and its changes following exercisetraining in epileptic rats with Pentylenetetrazole. Materials and Methods: In this experimental study, 70 male rats were placed in 7 groups. An intact group, three groups ...
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Introduction: There has been no report on the effect of epilepsy on liver enzymes and lipoproteins and its changes following exercisetraining in epileptic rats with Pentylenetetrazole. Materials and Methods: In this experimental study, 70 male rats were placed in 7 groups. An intact group, three groups of Kindle and three groups of non-Kindle who received PTZ or normal saline injections every 48 hours until the animals were kindled. 24 hours after Kindling, blood samples were collected in intact group and two groups of Kindle and non-Kindle. One Kindle group and one non-Kindle group from the remaining four groups performed aerobic exercise for six weeks, and the other two groups were inactive for six weeks. Blood were collected 24 hours after the 6-week period, and were compared with control groups. Results: After 4 weeks of Kindling period, total cholesterol, triglycerides, low-density lipoprotein, liver enzymes (P <0.001) and antigenic coefficient (P <0.01) increased significantly in the epileptic group. After six weeks of aerobic exercise in Kindle animals; Triglycerides (P <0.001), liver enzymes (P <0.01) and antigenic coefficients significantly reduced, and high-density lipoprotein significantly increased (P <0.01). Conclusion: The results showed that aerobic exercise in epileptic rats with Pentylenetetrazole improved lipid profile impairement and increased liver enzymes caused by epilepsy.
Physiology & Pharmacology
Zohreh Tavasoli; Narges Hosseinmardi; Mahyar Janahmadi; Mehdi Golpayegani; Farhad Salari; Delaram Jafarzadeh
Volume 24, Issue 1 , March and April 2017, , Pages 71-77
Abstract
Background & Objectives: Considering the role of glial cells in synaptic transmission, regulation of neurotransmitter concentration in synaptic cleft, K+ buffering, and releasing the gliotransmitters, the purpose of this study is to investigate the effect of glial cells inhibition on the progression ...
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Background & Objectives: Considering the role of glial cells in synaptic transmission, regulation of neurotransmitter concentration in synaptic cleft, K+ buffering, and releasing the gliotransmitters, the purpose of this study is to investigate the effect of glial cells inhibition on the progression of seizures induced by chemical kindling in rats. Materials & Methods: In chemical kindling, animals received Pentylenetetrazol, 35 mg/kg each 48 hours, intraperitoneally and five different stages of seizure were appeared gradually and seizure parameters including maximum seizure stage (SS), stage 4 latency (S4L), stage 4&5 duration (S5D), and seizure duration (SD) were measured during 20 min after PTZ injection. Then seizure parameters were evaluated in animals treated with intracerebroventricular (icv) administration of Fluorocitrate (as a glial cells inhibitor), injected 30 min before PTZ, and compared with PTZ treated animals. Results: Results showed that glial cells inhibition with ICV injection of Fluorocitrate decreased SS, S5D, and SD and increased S4L significantly (P<0.05, P<0.01, P<0.001). Conclusion: On the basis of obtained results, it may be concluded that glial cells inhibition reduces spreading rate of epileptiform activity in the nervous system, and the duration of neuronal hyperexcitability and, also, prevents the progression of seizure to final stages.
Simin Namvar Aghdash; Roya Mirzaee
Volume 22, Issue 5 , November and December 2015, , Pages 902-908
Abstract
Background & Objectives: Epilepsy is one of the most common neurological disorders in the world. It affects, at least, on 0.5–2% of people worldwide. It causes serious physical, psychological, social, and economic consequences. Despite a variety of current procedures for treatment of epilepsy, ...
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Background & Objectives: Epilepsy is one of the most common neurological disorders in the world. It affects, at least, on 0.5–2% of people worldwide. It causes serious physical, psychological, social, and economic consequences. Despite a variety of current procedures for treatment of epilepsy, research for discovering new drugs has been continued. Although medicinal plants have been used in traditional medicine for treatment of epilepsy, only a few of the medicinal plants have been examined scientifically. The aim of this study was to study the effect of Thymus vulgaris extract in the treatment of seizure.
Materials & Methods: In this study, 48 mice have been chosen randomly and divided into 6 groups, including control group, sham group that received distilled water, and 4 experimental groups that received aqueous extract of Thymus vulgaris in doses of 100, 200, 400 and 800 mg/kg for 4 weeks. 30 minutes after gavage with different doses of the extract or distilled water, pentylenetetrazol was injected to experimental and sham groups. Animals immediately transferred to a special cage and the seizure behaviors and parameters were recorded by a camera. Then the different phases of seizure were evaluated.
Results: Data analysis indicated that the aqueous extract of Thymus vulgaris had a significant effect on PTZ-induced seizure. The results showed that therapy by this extract increases latency time for onset of seizure and prevents progress of seizure phases.
Conclusion: The attained results showed that Thymus vulgaris extract has anticonvulsant effect on PTZ-induced seizure. Thus, it may be used in seizure treatment.