Reza Ghotaslou; Tahereh pirzadeh; Aylin Esmailkhani; Abed Zahedi Bialvaie; Hamed Ebrahimzadeh Leylabadlo
Volume 29, Issue 2 , July and August 2022, , Pages 179-194
Abstract
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most effective human pathogens, as over half of the world's population is colonized with this Gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key ...
Read More
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most effective human pathogens, as over half of the world's population is colonized with this Gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of the various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma (MALT). This review concerns some of the most recent developments in diagnostic methods of H. pylori infection and it has been studied in different clinical conditions. Only highly accurate tests should be used in clinical practice, and the sensitivity and specificity of an adequate test should exceed 90%. The choice of tests should take all items among into account clinical circumstances, the likelihood ratio of positive and negative tests, the cost-effectiveness of the testing strategy, and the availability of the tests.
Internal Medicine
hassan Ramshini; afsaneh kaffash
Volume 27, Issue 6 , January and February 2021, , Pages 852-859
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2, has become the current health concern to the entire world. Initially appeared in Wuhan, China around December 2019, it spread to almost 216 countries due to its high contagious nature, so the World ...
Read More
Introduction: The coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2, has become the current health concern to the entire world. Initially appeared in Wuhan, China around December 2019, it spread to almost 216 countries due to its high contagious nature, so the World Health Organization recently declared the pandemic feature of the infection. SARS-CoV-2(COVID-19) which is genetically similar to SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) is an enveloped, single and positive-stranded RNA virus with a genome comprising 29,891 nucleotides, which encode the 12 putative open reading frames responsible for the synthesis of viral structural and nonstructural proteins which are very similar to SARS-CoV and MERS-CoV proteins. Currently, there are no approved treatments for COVID-19. For this reason, we reviewed existing publications about Coronavirus Disease 2019 (COVID-19) regarding epidemiology, pathophysiology, diagnosis and treatments. Materials and Methods: Given the various investigations on the Virus (15928 publications in MEDLINE database, Until May 26, 2020) and various clinical data generated by the large number of laboratories, clinicians need accurate evidence regarding effective medical treatments for this infection. In this review, MEDLINE, SCIENCE DIRECT and Scopus databases were searched for relevant articles. Results: Since the emergence of COVID-19 infection there was a large interest in the development of an effective therapy for this disease. In this review, we summarized the available literature on possible therapeutic options including in vitro, animal and human studies. This review has presented a picture of the current findings on the epidemiology, clinical features, diagnosis, management, and prevention of COVID-19. Conclusion: The COVID-19 epidemic represents the world's biggest public health crisis. Clinical trials that have begun to look for potential treatments for COVID-19 are very high, but unfortunately have not yet led to the development of an effective drug. Thus, to overcome on this crisis preventive and coordinated emergency measures between all countries are needed.
Anesthesiology
ahmad kachoie; sedigheh hoseini; Azam Biderafsh; iman kamalian; saeed madani; enayatollah noori
Volume 27, Issue 5 , November and December 2020, , Pages 692-697
Abstract
Introduction: The accuracy of the diagnosis of acute appendicitis has been agreed at 85%. Based on this and considering that appendectomy is one of the most common surgeries in Shahid Beheshti Educational and Medical Center in Qom, we decided to compare the accuracy of acute appendicitis diagnosis with ...
Read More
Introduction: The accuracy of the diagnosis of acute appendicitis has been agreed at 85%. Based on this and considering that appendectomy is one of the most common surgeries in Shahid Beheshti Educational and Medical Center in Qom, we decided to compare the accuracy of acute appendicitis diagnosis with the agreed standard in patients undergoing appendectomy in this center.
Materials and Methods: This was a retrospective cross-sectional study. It was performed in Shahid Beheshti Hospital in Qom in 2015-2016. Sampling was done by simple random method. Information including sex and age as well as patient pathology diagnosis and complications such as gangrene and appendix perforation were entered into the checklist and analyzed by SPSS software.
Results: In the present study, 250 people were studied, 167 (66.8%) were male and 83 (33.2%) were female. The mean age of patients with acute appendicitis was 23 years and those with other diagnoses had a mean age of 21 years. Also, 167 (66.8%) of them were male and only 83 (33.2%) were female. In this study, out of 250 patients who underwent appendectomy with a diagnosis of acute appendicitis, 194 (77.6%) had a diagnosis of acute appendicitis in pathology and 56 (22.4%) had another diagnosis. The diagnosis of acute appendicitis was 45.5% in women and 44.6% in men, which did not differ much.
Conclusion: Considering these findings and the lower accuracy of appendicitis diagnosis than the agreed standard, it can be concluded that a number of appendectomy procedures, especially appendectomy in women, were unnecessary. It is necessary to examine more carefully before the operation. Received
Sanaz Tabarestani; mohamad reza Noori-Daloii
Volume 17, Issue 2 , July and August 2010, , Pages 74-87
Abstract
Breast cancer is the most common cancer among women, and one out of 8 or 10 women is diagnosed with breast cancer. This type of cancer is an extremely heterogenous disease, which is classified into multiple categories including LCIS (Lobular carcinoma in situ) , DCIS (Ductal carcinoma in situ), and invasive ...
Read More
Breast cancer is the most common cancer among women, and one out of 8 or 10 women is diagnosed with breast cancer. This type of cancer is an extremely heterogenous disease, which is classified into multiple categories including LCIS (Lobular carcinoma in situ) , DCIS (Ductal carcinoma in situ), and invasive carcinoma. BRCA1 and BRCA2 are two major high-risk genes associated with hereditary breast cancer. Mutations in CHEK2 gene also contribute to a substantial fraction of familial breast cancer. Susceptibility alleles in other genes are also rare causes of breast cancer. More than 1000 mutations have been identified in BRCA1 and BRCA2, and molecular assays for detecting mutations in these genes are now well established. Mutations in BRCA1 and BRCA2 cause genomic instability, which leads to alterations in additional key genes including tumor suppressor genes and/or oncogenes. There is a promise of tailoring treatment programs for individual women in near future. The emergence of miRNAs as regulators of gene expression identifies them as a novel candidate for diagnostic and prognostic indicators and therapeutic targets. The ability of miRNAs to simultaneously regulates many target genes and makes them attractive candidates for regulating stem cell self-renewal and cell fate decisions. The involvement of miRNAs in the initiation and progression of human malignancy holds much potential for new developments in current diagnostic and therapeutic strategies in the management of patients with breast cancer. The identification of novel miRNAs, the elucidation of their mRNA targets, and an understanding of their functional effects will improve our knowledge of the roles of these novel biomarkers in carcinogenesis, including breast cancer, and open avenues for potential therapeutic intervention.