Physiology & Pharmacology
Seyed Arman Razavi; Amin Bigham-Sadegh; Iraj Karimi; Siavash Sharifi; Iman Hafar
Volume 28, Issue 3 , May and June 2021, , Pages 387-395
Abstract
Introduction: Phenytoin ointment is a usual medicine for wound healing. Aloe vera gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate ...
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Introduction: Phenytoin ointment is a usual medicine for wound healing. Aloe vera gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate the effects of phenytoin ointment1%, aloe vera gel, royal jelly and honey on skin wound healing in rabbit animal model. Materials and Methods: 5 rabbits with 50 skin wounds were used in this study. Phenytoin ointment1%, aloe vera gel, royal jelly and honey were used in four wounds and another was considered as an untreated control. Macroscopic study was performed on days 4, 8, 12, 16 and 20 after wounding and histopathologic study was done on the days 10 and 21 from the wounds. Results: On the 8th and 12th days in the Aloe vera gel, royal jelly and honey groups, the area of the wound had a significant difference (p < 0.05) than group1 (phenytoin), indicating a faster reduction of the wound surface than the phenytoin group. On the 16th day after surgery, the ulcer surface of the honey group was completely closed and on day 20 all the wounds were fully restored in all groups. Also, histopathologic studies on 10 and 21 days showed no significant difference between the studied groups and all wounds were completely restored on day 20. Conclusion: Finally, the results of this Study showed that phenytoin 1% ointment, aloe vera gel, royal jelly and honey, all had a good effect on wound healing.
Mohammad Shoja; Mohammad Novrozi; Somayyeh Rahimi; Ali Mohammad Jafari; Mohsen Shoja
Volume 21, Issue 1 , March and April 2015, , Pages 116-121
Abstract
Introduction: the toxic epidermal necrosis syndrome is defined as severe skin and mucosal reactions which usually appears by some drugs such as phenytoin.
Case Presentation: a 35-year-old man who consumed phenytoin hospitalized due to diffuse mucocutaneous lesions and bullous lesions. After diagnosing ...
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Introduction: the toxic epidermal necrosis syndrome is defined as severe skin and mucosal reactions which usually appears by some drugs such as phenytoin.
Case Presentation: a 35-year-old man who consumed phenytoin hospitalized due to diffuse mucocutaneous lesions and bullous lesions. After diagnosing its etiology, therapeutic actions were done similar to severe burns which led to improvement of wounds and discharging from the hospital.
Conclusion: finding the etiology of every disease is crucial step in its treatment. When the disease is caused by drug, it is necessary to discontinue immediately consumption of this and start treatment.