genetics
Reyhaneh Ravanbakhsh Gavgani; Esmaeil Babaei; Mohammad Ali Hosseinpourfeizi; Vahid Montazeri
Volume 26, Issue 3 , September and October 2019, , Pages 285-292
Abstract
Introduction: Breast cancer is the most common tumor malignancy among women worldwide. Studies have revealed new class of RNA molecules named Long non-coding RNAs that play important role in tumor development, progression and metastasis. Therefore, this study aimed to evaluate long non-coding RNA lncUSMycN ...
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Introduction: Breast cancer is the most common tumor malignancy among women worldwide. Studies have revealed new class of RNA molecules named Long non-coding RNAs that play important role in tumor development, progression and metastasis. Therefore, this study aimed to evaluate long non-coding RNA lncUSMycN expression in breast cancer. Methods: In this study, 40 breast tumor with invasive ductal carcinoma and 40 normal marginal tissues were collected and after RNA extraction using TRizol kit, cDNA was synthesized. Expression level of lncUSMycN was obtained by applying qRT-PCR method. In order to evaluate association of lncUSMycN expression in tumor compared to normal tissues REST software was used. Biomarker potential of lncUSMycN was evaluated by drawing ROC curve using SigmaPlot. In addition, relationship between lncUSMycN expression and clinicopathological features was analysed. Results: Results from REST indicated significant upregulation of lncUSMycN in tumor tissues compared to normal marginal specimens (95% CI, p =0.001). ROC curve analysis demonstrated the biomarker potential of lncUSMycN (ROCAUC =0.72, p=0.0006). Evaluation of the relationship between lncUSMycN expression and clinicopathological features revealed that there are significant association between lncUSMycN expression and early stages (95% CI, P=0.005) and well-differentiated tumors (95% CI, P=0.046).Conclusion: Considering upregulation of lncUSMycN expression in invasive ductal carcinoma this lncRNA may be probably considered as a new potential diagnostic biomarker for breast cancer.
Nasim Sharif; Alireza Agha yosefi
Volume 21, Issue 1 , March and April 2015, , Pages 81-92
Abstract
Background: The use of coping strategies with stress in coronary heart disease (CHD) patients, can lead to significant changes in fasting blood sugar (FBS) level, but researchers have not empirically explored it. This study aimed to analyze the relationship between coping strategies with stress and FBS ...
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Background: The use of coping strategies with stress in coronary heart disease (CHD) patients, can lead to significant changes in fasting blood sugar (FBS) level, but researchers have not empirically explored it. This study aimed to analyze the relationship between coping strategies with stress and FBS level in CHD patients.
Materials and methods: This descriptive and correlative study was conducted in 2011. Study population was all patients who had referred to Shahid Rajaie Heart Hospital. A total of 44 CHD patients hospitalized in internal wards for women and men, and private units, whose coronary artery occlusion had been confirmed by angiography, were selected by judgmental sampling method. In this study, Lazarus and Folkman's Coping Questionnaire, and blood sugar kit (Pars Azmoon Company) were used. The data were analyzed by descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression, in SPSS 17.
Results: The results showed that, there was a significant positive correlation between emotion-based coping strategies and FBS (r=0.680, P