Physical Education
zohreh mirzavand; mohammad fathi; mostafa bahrami
Abstract
Introduction: Inactivity plays a role in diabetes and increasing tissue oxidative stress and this study aimed to investigate the effect of a period of aerobic exercise on malondialdehyde, superoxide dismutase, and glutathione peroxidase in the heart tissue of male diabetic rats.
Materials and Methods: ...
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Introduction: Inactivity plays a role in diabetes and increasing tissue oxidative stress and this study aimed to investigate the effect of a period of aerobic exercise on malondialdehyde, superoxide dismutase, and glutathione peroxidase in the heart tissue of male diabetic rats.
Materials and Methods: 44 male Wistar rats (200-250 grams) were randomly divided into 4 ten groups of healthy, diabetic, training, and diabetes+ training. After 12 hours of food deprivation, diabetes was induced by intraperitoneal injection of STZ solution, The training groups did aerobic exercise 5 days a week for 6 weeks. 48 hours after completion of the protocol, anesthetized animals and heart tissue were removed. ELISA method was used to measure the amount of superoxide dismutase, malondialdehyde, and glutathione peroxide. Data were analyzed with one-way ANOVA, Tukey's post hoc tests, SPSS, and GraphPad software.
Results: The results showed that superoxide dismutase and glutathione peroxide in the diabetes group were significantly lower than the control, exercise, and diabetes+exercise groups (p≤0.0001). Also, superoxide dismutase and glutathione peroxide were significantly higher in the diabetes+exercise group than in the control and exercise groups (p≤0.0001). Malondialdehyde in the diabetes group was significantly higher than in the diabetes+exercise group, the exercise group, and the control group (p≤0.0001). Malondialdehyde was significantly higher in the diabetes+exercise group than in the diabetes and control groups (p≤0.0001).
Conclusion: aerobic training can have a positive effect on the heart tissue in diabetic rats by reducing oxidative stress.
Physical Education
Saber Saed-Mocheshi; Marziyeh Saghebjoo; Zakaria Vahabzadeh; Dariush Sheikholeslami Vatani
Volume 27, Issue 3 , September and October 2020, , Pages 394-401
Abstract
Background and Objectives: Lifestyle modification is an important aspect of preventing various diseases, including various types of cancer. The aim of the present study was to investigate the effect of eight weeks of aerobic training and green tea extract on NF-κB, COX-2 and suppressor protein ...
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Background and Objectives: Lifestyle modification is an important aspect of preventing various diseases, including various types of cancer. The aim of the present study was to investigate the effect of eight weeks of aerobic training and green tea extract on NF-κB, COX-2 and suppressor protein of p53 in prostate tissue of healthy rats.Materials & Methods: 32 male Wistar rats were randomly divided into four groups: green tea extract, exercise training, green tea extract + exercise training, and control. The exercise training program included aerobic training on a low to moderate intensity on the treadmill (at a speed of 3-10 m/s, 3 sets of 15 min with 2 min of rest between sets, 5 days a week). Green tea extract was gavaged at a dose of 1.3 ml of solution at a concentration of 10 mg/100 ml (3 sessions per week). Scarify was performed 48 hours after the end of the intervention. The results were analyzed using parametric statistical methods of analysis of covariance and one way ANOVA.Results: Aerobic training significantly increased NF-κB level compared to the control group (P = 0.02). The combination of aerobic training and consumption of green tea extract did not significantly change the level of NF-κB. The COX-2 and p53 levels were not significantly different after aerobic training and green tea extract (P > 0.05).Conclusion: Green tea supplementation seems to modulate NF-κB level following aerobic training, which can reflect the anti-inflammatory effects of green tea and its role in preventing prostate cancer.
Physical Education
Fatemeh Rostami; Ramin Shabani
Volume 26, Issue 2 , July and August 2019, , Pages 185-193
Abstract
Background: It seems that exercise training can be effective in improving glucose homeostasis and blood lipids by inducing circulating level of irisin. Therefore, the purpose of this study was to evaluate the effect of eight week aerobic training on serum irisin, blood lipid and blood sugar in untrained ...
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Background: It seems that exercise training can be effective in improving glucose homeostasis and blood lipids by inducing circulating level of irisin. Therefore, the purpose of this study was to evaluate the effect of eight week aerobic training on serum irisin, blood lipid and blood sugar in untrained women. Materials and Methods: This semi- experimental study was conducted on 20 sedentary volunteer women among a university of Rasht city in two groups. The control group conducted the routine daily activities, but the experimental group participated in 65 min aerobic training, three times a week for eight consecutive weeks. Blood lipids, glucose homeostasis and circulating irisin were assessed at baseline, and after 8 weeks of interventions. Data were analyses using SPSS version 22 and A P-value of P< 0.05 was considered statistically significant.Results: In the training group, insulin (p=0.02) and HOMA (p=0.04) were decreased and HDL-C (p=0.00) was increased following 8-weeks of intervention. However, there were no significant changes in fasting blood sugar, triglyceride, cholesterol, LDL-C and irisin (P>0.05). In the control group, fasting blood sugar (p=0.04), insulin (p=0.01), HOMA (p=0.00), triglyceride (p=0.03) and irisin (p=0.03) were increased following 8-weeks of study period. After intervention, participants undergoing exercise training had significantly lower cholesterol (p=0.00), triglyceride (p=0.02), insulin (p=0.00) and HOMA (P=0.00) and higher HDL-C (p=0.00) compared with the control group.Conclusion: It seems that aerobic training in sedentary women is associated with an improvement in glucose homeostasis and HDL-C independently of the irisin changes.
Physical Education
Maryam Shabani; Mohammad Sharafati Moghadam; Farhad Daryanoosh; Hamed Alizade Pahlavani
Volume 24, Issue 5 , September and October 2018, , Pages 305-310
Abstract
Background Objectives: Cardiac troponin as a marker of heart, play a vital role in the diagnosis of heart disease. The purpose of this study was to assess the effect of four weeks high intensity interval training (HIIT) and aerobic training on troponin T content in healthy male rats’ myocardial ...
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Background Objectives: Cardiac troponin as a marker of heart, play a vital role in the diagnosis of heart disease. The purpose of this study was to assess the effect of four weeks high intensity interval training (HIIT) and aerobic training on troponin T content in healthy male rats’ myocardial tissue.Materials & Methods: In this study, 36 Wistar rats 2 months with an average weight 180±20 were selected and randomly assigned divided into three groups, control (n=12), HIIT (n=12), and aerobic (n=12) groups; experimental group 5 days a week in accordance with their training program for 4 weeks to exercise. After 4 weeks, ANOVA test and Bonferroni post hoc test were used for analysis.Results: The results showed a no significant difference between the mean troponin T HIIT exercise and control groups. Troponin T is also a no significant difference between the Aerobic training and control groups.Conclusions: Based on the findings of troponin T in none of the groups had no significant change, It seems that exercise HIIT and Aerobic training with duration of 4 weeks do not damage the heart tissue.
Mahmood Nikseresht
Volume 25, Issue 2 , May and June 2018, , Pages 205-215
Abstract
Background: Regular exercise training has been postulated as an important strategy to reduce inflammatory markers, but it is still not clear what type of training is most appropriate. The purpose of this study was to compare the effects of nonlinear resistance training (NRT) and aerobic interval training ...
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Background: Regular exercise training has been postulated as an important strategy to reduce inflammatory markers, but it is still not clear what type of training is most appropriate. The purpose of this study was to compare the effects of nonlinear resistance training (NRT) and aerobic interval training (AIT) on interleukin-18 (IL-18) and C-reactive protein (CRP) in obese young men. An additional aim was to compare the inflammatory markers between the obese and non-obese men to determine the obesity effect. Materials and Methods: Thirty-eight obese and young men (age=31.4±5.2 year, body fat%=27.3±1.5) were randomly assigned to NRT (n=14), AIT (n=12) and control (CON, n=12) groups. An age-matched control group of non-obese men were also recruited for baseline comparison. Independent t-test and 2-factor repeated measures analysis of variance (ANOVA) were used for analyzing data.Results: No significant differences were noted at baseline between obese and non-obese men for IL-18 (P=0.17), CRP (P=0.77) and VO2peak (P=0.24). After training, VO2peak increased in NRT (P=0.03) and AIT (P=0.001) compared to the CON, but in AIT more than in NRT (P=0.02). Compared to the CON, both of training were equally effective at reducing fat mass (P=0.001). However, there were no significantly changes in IL-18 (P = 0.26) and CRP (P=0.15) after training. Conclusion: Lack of significant differences for IL-18 and CRP between obese and non-obese men might be due to the similar status in age and aerobic fitness. It seems that 2 exercise programs could not make a significant reduction in the concentrations of inflammatory markers.
Physical Education
Rambod Khajei; Amir Hossein Haghighi; Mohammad Reza Hamedinia; Amir Rashid Lamir
Volume 24, Issue 1 , March and April 2017, , Pages 79-88
Abstract
Background & Objectives: Cardiac rehabilitation is the most important proceeding to reduce the effects of heart surgery and its effects on cardiovascular disease. Exercise training because of low cost and being attractive can be a motivation for patients with cardiac rehabilitation programs.Exercise ...
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Background & Objectives: Cardiac rehabilitation is the most important proceeding to reduce the effects of heart surgery and its effects on cardiovascular disease. Exercise training because of low cost and being attractive can be a motivation for patients with cardiac rehabilitation programs.Exercise has influence on blood cellular components, especially the number of white blood cells, metabolism, metabolites, peptides and different type of gene expression.The aim of this study was to examine the effect of aerobic training on monocytes gene expression ABCG5 in middle-aged men after heart bypass surgery. Materials & Methods: In this semi-experimental study, 20 middle-aged malepatient who had coronary artery bypass surgery, were subjected to the study and were randomly assigned into two groups: control (N=10) and aerobic training (N = 10) groups. Blood samples were taken from subjects before and after training sessions.Monocytes isolated by centrifugation and m-RNA purified by Real-Time PCR was performed.Data were analyzed by ANOVA with repeated measures (SPSS version 16). Results: Results showed that, as a result of exercise training, there was significant increase in mRNA expression of gene ABCG5 in the experimental group than control group. Conclusion: It seems that exercise training as part of the cardiac rehabilitation in patients undergoing coronary artery bypass grafting can improve the reverse cholesterol transport process in the patients by impressing the expression of genes involved in lipid metabolism.
Ali Heidarianpour; Maryam Keshvari
Volume 23, Issue 6 , January and February 2017, , Pages 916-925
Abstract
Background: Several studies have suggested the role of inflammatory factors in the development and progression of complications of diabetes. Among the inflammatory biomarkers CRP, has the most rapid reaction and subside the normal level following a successful treatment. Sectional and longitudinal studies ...
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Background: Several studies have suggested the role of inflammatory factors in the development and progression of complications of diabetes. Among the inflammatory biomarkers CRP, has the most rapid reaction and subside the normal level following a successful treatment. Sectional and longitudinal studies have confirmed the anti-inflammatory effects of exercise and its effects on various inflammatory and pre inflammatory cytokine mentioned. The purpose of this study was to compare three different ways of training on CRP levels in type 2 diabetic patients after a ten -week training is designed.
Methods: 52 patients with type 2 diabetes (65-40 years) were randomly divided into four groups: aerobic training, resistance, combined (aerobic and resistance) and control groups and each group consisted of 13 subjects. Exercise 3 times a week for 60 minutes each session lasted for 10 weeks.The high-sensitivity CRP (hs-CRP) at baseline and at the end of the study were measured by ELISA. The data analysis was done by SPSS20 and p<0.05 considered as significance level.
Results: aerobic and combined exercise significantly subsides hs–CRP level in type II diabetes patients, this decrease was more significant pronounced in combined exercise and resistance exercise has not significantly effect on hs–CRP level
Conclusion: According to the findings aerobic exercise training is particularly suitable compound to prevent inflammatory biomarkers such as CRP elevation in patients with type 2 diabetes. Therefore more studies in future maybe useful to prevent diabetic complications.
Fatah Moradi; Soran Heidari; Akbar Pejhan
Volume 23, Issue 4 , September and October 2016, , Pages 714-723
Abstract
Background Physical inactivity and obesity have been directly associated with elevated inflammatory markers involving in atherosclerosis, coronary artery disease, and Type II diabetes. The purpose of this study was to survey the effect of 12-week aerobic training on serum levels of interleukin-18 (IL-18) ...
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Background Physical inactivity and obesity have been directly associated with elevated inflammatory markers involving in atherosclerosis, coronary artery disease, and Type II diabetes. The purpose of this study was to survey the effect of 12-week aerobic training on serum levels of interleukin-18 (IL-18) and high-sensitivity C-reactive protein (hsCRP) in sedentary obese men.Methods & Materials In this clinical trial study, 20 sedentary obese men were randomly placed at two groups: aerobic training (n=10, age: 27.8±3.2 y, body fat percentage: 31.7±3.4, BMI: 32.0±3.5 kg/m2) and control (n=11, age: 26.7±2.6 y, body fat percentage 31.4±3.2, BMI: 32.3±2.8 kg/m2). For all subjects, height, weight, body mass index, body fat percentage, maximal oxygen consumption, serum levels of IL-18, and hsCRP (after 12 h fasting) were assessed prior to and after training. Aerobic training was accomplished for 12 weeks (3 sessions per week, intensity 60%-70% of the reserved heart rate, duration of each session 20-40 min). Data were analyzed by SPSS-16 by performing two-way ANOVA with repeated measures test. Statistical significance was accepted at PResults Twelve weeks aerobic training decreased serum levels of IL-18 and hsCRP in sedentary obese men, while no significant changes were observed in the control group.Conclusion It appears that aerobic training can, via influencing on parameters IL-18 and hsCRP, play an important role in reducing incidence of atherosclerosis, coronary artery disease, and Type II diabetics in sedentary obese men.
AmirHossein Haghighi; Hadi YarAhmadi; Maliheh Shojaee
Volume 20, Issue 5 , March and April 2014, , Pages 623-634
Abstract
Abstract
Introduction: Visfatin is a newly discovered adipokine which increases with obesity. It is not clear whether endurance training which induces changes in adipose tissue and blood lipids might decrease the plasma level of visfatin as well. The aim of this study was to investigate the effect of ...
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Abstract
Introduction: Visfatin is a newly discovered adipokine which increases with obesity. It is not clear whether endurance training which induces changes in adipose tissue and blood lipids might decrease the plasma level of visfatin as well. The aim of this study was to investigate the effect of 9 weeks of aerobic training on serum visfatin level and insulin resistance index in obese women.
Materials and methods: Method of research was semiexperimental. Twenty-eight obese female volunteered and were randomly divided into experimental (14 subjects with means of weight 82 ± 10.2 kg, and BMI 34.2 ± 4.3 kg/m2) and control (14 subjects with means of weight 79.9 ± 9.5 kg, and BMI 34 ± 3.9 kg/m2) groups. Aerobic training protocol consisted of 4 sessions per week for 9 weeks. Each training session was a slow running trial at intensity of 65 to 75 percent of maximal heart rate for a period of 15 minutes. To follow the principle of overload, half-a-minute was added to each session after the second week, so that, at the last session the running time reached to 31 minutes. Before and after the training period, blood sampling was performed. Data were analyzed using independent t test and ANCOVA.
Results: Results showed significant reduction of serum visfatin level (p < 0.05), and no significant difference in insulin resistance index, serum HDL, LDL, TC and TG between the control and experimental groups (p > 0.05). In addition, aerobic training reduced significantly body mass index, body weight, waist to hip ratio, body fat percent, and increased significantly maximum oxygen uptake (p < 0.05).
Conclusion: It can be said that 9 weeks of aerobic training can cause significant reduction of serum visfatin and no significant change in insulin resistance index in obese women.