Psychology
Mahya Ebrahimi; Sima Ghodrati; Hamidreza Vatankhah kourandeh
Volume 29, Issue 1 , May and June 2022, , Pages 1-12
Abstract
Background and Objective:Acceptence and commitment Therapy is One of the Third Wave behavioral Therapies for the treatment of anxiety Disorders.the purpose of this study to investigate the the effectiveness of Acceptance and Commitment Therapy on Resiliency and Self-Concept in children with cancer.Methods:The ...
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Background and Objective:Acceptence and commitment Therapy is One of the Third Wave behavioral Therapies for the treatment of anxiety Disorders.the purpose of this study to investigate the the effectiveness of Acceptance and Commitment Therapy on Resiliency and Self-Concept in children with cancer.Methods:The Present Study was quasi-experimental with post-test pretest design with control group.The statistical population included all children with cancer admitted to Imam Khomeini Hospital in Tehran in 1398 , of which 30 children were randomly assigned to experimental and control group.Pears-Harris (1969) Self-Concept questionnaire and Connor-Davidson(2003) resilience were randomly assigned to experimental and control groups.For the experimental group , Acceptence and commitment Therapy was presented in six session of 60-minutes. Data were analyzed by analysis of covariance using SPSS24 software.Results:The results showed that the Treatment based on acceptance and commitment had an Effecton self-concept(p = 0.001, F = 24.05) and Resiliency (p = 0.002, F = 11.88)in children with cancer.The findings showed That Acceptance and Commitment based Therapy on the components of Behavior , Anxiety , popularity , Resiliency and self concept on children with cancer.Conclusion:Acceptance and commitment therapy has a positive effect on resilience and self concept of children with cancer. Therefore the use of such treatments methods is recommended to counselors and child psychologists.
immunology & Biochemistry
Jasmin Kharazmi-Khorassani; Ahmad Asoodeh
Volume 28, Issue 1 , January and February 2021, , Pages 69-81
Abstract
Introduction: Thymosin alpha-1 (zadaxin) a 28-amino acid peptide, which was first identified in the calf thymus. This peptide is a biological modifier which leads to activation of various cells of the immune system. In the recent years, thymosin alpha-1 has been studied in in vitro and in vitro studies ...
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Introduction: Thymosin alpha-1 (zadaxin) a 28-amino acid peptide, which was first identified in the calf thymus. This peptide is a biological modifier which leads to activation of various cells of the immune system. In the recent years, thymosin alpha-1 has been studied in in vitro and in vitro studies to evaluate its biological activities and therapeutic applications. Materials and Methods: This study was done to summarize findings from the biological and clinical applications of thymosin alpha-1 peptide. We searched at the sites of Google, Google Scholar and PubMed over 1966-2019 using Thymosin alpha-1, Immunomodulatory, Cancer, Hepatitis and AIDS as keywords. Results: The results showed that thymosin alpha-1 interacts with Tolllike receptors (TLR) and brings about to activation of some intracellular pathways that ultimately stimulate the immune system by modulating cytokine production, enhancing T-cell and dendritic cells. The peptide also shows antitumor activity and a protective role against oxidative damage by increasing the level of antioxidant enzymes. Clinical studies with thymosin alpha-1 have been shown a broad effective application against many infectious diseases, including hepatitis B and C and AIDS. In addition, thymosin alpha-1 is considered as a promising and adjunctive approach for subjects suffering from some cancers such as hepatocellular carcinoma and melanoma. Conclusion: The results of this study indicate the multiple biological properties of thymosin alpha-1. However, further studies are needed to understand the mechanism of action of thymosin alpha-1.
genetics
nasser pouladi; mohammadali hosseinpourfeizi
Volume 25, Issue 3 , July and August 2018, , Pages 399-407
Abstract
Background: Thyroid cancer is the most common malignant endocrine tumor, and the incidence was rising worldwide over the last three decades. TP53 is one of the most important tumor suppressor genes in the genome, and its mutations are found in approximately 50% of human cancers. It plays pivotal roles ...
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Background: Thyroid cancer is the most common malignant endocrine tumor, and the incidence was rising worldwide over the last three decades. TP53 is one of the most important tumor suppressor genes in the genome, and its mutations are found in approximately 50% of human cancers. It plays pivotal roles in the regulation of cell cycle arrest and apoptosis. The aim of this study was to analyze TP53 gene mutations among thyroid cancer patients in East- Azerbaijan. Material and Methods: 40 tumor samples have been collected from thyroid cancer patients from Tabriz hospitals between 2007-2009. DNA was extracted by Proteinase K – Iso propanol method and then the mutations in p53 gene from exon5 to exon8, were detected by Polymarase Chain Reactions (PCR) and direct sequencing techniques.Results: Alterations in the p53 gene were detected in 12.5% of the patients, including single nucleotide polymorphisms and mutations, including codon216 (GTG>GTA), codon215 (AGT>ATT) and codon273 (CGT>CAT) mutations (each mutation in one of the cases) and two linked polymorphisms 14181C>T and 14201T>G (in two cases).Conclusion: This result helps us to clarify p53 mutation status among Azerbaijani thyroid cancer patients.
Korosh Bani Hashem; Fatemeh Golestan Jahromi; Nikzad Ghanbari; Mansour Moazen
Volume 21, Issue 5 , September and October 2014, , Pages 735-742
Abstract
Background and purpose: Stress Inoculation Training has positive effect onreducing tension in patients with cancer, but this intervention hasn’t done in patients with prostate cancer yet, so the purpose of present study is to investigate the effect of stress inoculation training on depression and ...
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Background and purpose: Stress Inoculation Training has positive effect onreducing tension in patients with cancer, but this intervention hasn’t done in patients with prostate cancer yet, so the purpose of present study is to investigate the effect of stress inoculation training on depression and anxiety in patient with prostate Cancer.
Materials and Methods: The statistical society of this study included men with prostate cancer who had refered to the Cancer Therapy Centers of Kermanshah in Feb 2014. 30 participants were randomly selected and divided in two groups (15 per group) of control and experiment. The applied instrument in this research was SCL-90-R scale. In order to perform data analysis, MANCOVA was used and results were extracted from SPSS software version 20.
Results: Results indicated that stress inoculation training have had a significant effect on reducing anxiety and depression in patients with prostate cancer of experiment group compared with control group (F=11/72 and P=0/002 for depression and F=21/87 and P
Sakineh Kazemi Noreini; Mohammad Nebuni; Zahra Sadat Nori
Volume 20, Issue 2 , May and June 2013, , Pages 122-132
Abstract
Introduction: Telomere maintenance is essential for the continued proliferation of dividing cells, and is implicated in chromosome stability and cell immortalization. Telomerase activity, that allows cancer cells to maintain their telomeric DNA for an indefinite replicative capacity, is an attractive ...
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Introduction: Telomere maintenance is essential for the continued proliferation of dividing cells, and is implicated in chromosome stability and cell immortalization. Telomerase activity, that allows cancer cells to maintain their telomeric DNA for an indefinite replicative capacity, is an attractive target against cancer. A well known benzylisoquinoline alkaloid, papaverine, we focused on to evaluate its antiproliferaive effects on breast cancer MCF7 cells.
Methods: Cytotoxicity of the commercially available pure compound papaverine HCl (Sigma) was determined by MTT assay. A modified quantitative real-time polymerase chain reaction (PCR)-based telomerase repeat amplification protocol (TRAP) was used to estimate relative telomerase activity in papaverine-treated cells in comparison with the untreated control cells. Relative expression level of the catalytic subunit of telomerase (hTERT) gene was estimated using real time reverse transcription-PCR (RT-PCR).
Results: IC50 concentration of papaverine after 48 hours treatment was measured to 120 micromolar. At this concentration telomerase activity showed a considerable decrease (almost 70% in comparison with untreated control cells), in a concentration dependent manner. Quantitative real-time RT-PCR experiments indicated a similar reduction in transcription level of hTERT gene under treatment with papaverine.
Conclusion: Papaverine is a potent natural compound in suppression of cancer cell immortality most probably by anti-telomerase activity. It is a valuable putative compound for further development of promising anti-cancer agents.