Microbiology
Mahdieh Emadi; Javid Taghinejad; Ayda Ghaffarzadeh
Volume 27, Issue 5 , November and December 2020, , Pages 614-619
Abstract
Introduction: COVID-19 is a highly contagious infectious disease caused by a new coronavirus that can be transmitted from person to person through close contact. The aim of the present study is to investigate new information in the field of COVID-19 immunology. Materials and Methods: The present ...
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Introduction: COVID-19 is a highly contagious infectious disease caused by a new coronavirus that can be transmitted from person to person through close contact. The aim of the present study is to investigate new information in the field of COVID-19 immunology. Materials and Methods: The present study uses Google and Google Scholar search engines and articles indexed by reputable international scientific databases including Pub Med, MedLine, and the World Health Organization (WHO). In this study, published articles about COVID-19 and field of immunology were reviewed, and articles that did not have free access (Open Acess) and only access to abstracts were excluded from the study. Results: In total, studies have been suggested that the amount of cytokines such as IL-10, IL-7, IL-2, G-CSF, and TNF-α has been reported at high levels in patients. The ACE2 receptor is the target receptor for the Covid-19 virus, which binds to it after entering the lungs then IFN-I inhibit the primary replication and inhibition of the virus. Conclusion: After reviewing the articles, it was found that strengthening the immune system against viral infections is very important. The virus weakens the immune system by disrupting the production of type I interferon and reducing expression in the production of MHC-I, II. One of the best ways to fight COVID-19 is to get the right vaccine to boost immune system and produce T cells and cytokines.
immunology & Biochemistry
Mohammad Fereidouni; Mohammad Sadegh Naghizadeh; Afshin Derakhshani; Maryam Moossavi
Volume 26, Issue 5 , November and December 2019, , Pages 641-650
Abstract
Background: Vitamin D is a fat-soluble vitamin, which has been well known for its role on calcium and phosphate homeostasis since many years ago, but several studies in recent years have shown that vitamin D is involved in a variety of other processes which can be included its role on the immune system ...
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Background: Vitamin D is a fat-soluble vitamin, which has been well known for its role on calcium and phosphate homeostasis since many years ago, but several studies in recent years have shown that vitamin D is involved in a variety of other processes which can be included its role on the immune system and the related diseases.Materials and methods: In this article, the most recent findings about the role of vitamin D in the immune system and a number of immune-related diseases have been investigated.Results: Reviewing the articles shows that vitamin D and its receptor have an important role in the function of the body immune system. Conclusion: It seems that screening of vitamin D levels in the society can play a useful role not only in the preventing certain diseases and cancers but also in reducing the severity of the disease and better responding to common treatments.