Physical Education
Abbas Salhikia; Mohammad Parastesh
Volume 26, Issue 1 , March and April 2019, , Pages 89-97
Abstract
Background: The aim of present study was to investigate effects of endurance training on surfactant protein-D in streptozotocin–nicotinamide induced diabetic rats.Materials and Methods: In this experimental study، thirty-six adult male Wistar rats in the weight range of 200±48gr, randomly ...
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Background: The aim of present study was to investigate effects of endurance training on surfactant protein-D in streptozotocin–nicotinamide induced diabetic rats.Materials and Methods: In this experimental study، thirty-six adult male Wistar rats in the weight range of 200±48gr, randomly assigned in to four groups: healthy control, diabetic control, diabetic endurance training and healthy endurance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution (120 mg/kg) and STZ solution (65 mg/kg) was used. The endurance training protocol was performed for 8-week and Twenty-four hours after the last training session blood serum samples were examined for evaluating reproductive hormones. Data were analyzed using one-way ANOVA and Turkey’s Post Hoc test at 0.05%. Results: Endurance training caused a significant decrease in blood glucose in the endurance diabetic training group compared to the diabetic control group (P=0.000). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (P=0.001) and the insulin resistance index (P=0.000) was significantly lower than healthy controls. 8 weeks of endurance training significantly increased in SPD (P=0.041) in endurance diabetic training group compared to diabetic control group. Also, exercise significantly decreased insulin resistance index (P=0.000) and insulin (P=0.029) in endurance diabetic training group compared to diabetic control group.Conclusion: It seems that Endurance training by increasing the levels of serum SPD improve insulin resistance index in type 2 diabetic mice.Keywords: Streptozotocin–nicotinamide, Surfactant protein-D, Insulin, Training.