Microbiology
Kimia Saremi; Zahra Dehghani; Mahmood Vakili; Maryam Sadeh
Abstract
Introduction: Urinary tract infections (UTIs) are prevalent infectious conditions affecting individuals in their youth and middle age. The increased use of broad-spectrum antibiotics and the growing resistance to these drugs emphasize the necessity of understanding bacterial resistance patterns in the ...
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Introduction: Urinary tract infections (UTIs) are prevalent infectious conditions affecting individuals in their youth and middle age. The increased use of broad-spectrum antibiotics and the growing resistance to these drugs emphasize the necessity of understanding bacterial resistance patterns in the context of treatment. This study aimed to identify the resistance patterns of bacteria causing UTIs in patients attending two medical diagnostic and treatment centers in Yazd, Iran.Materials and Methods: Conducted for one year (2018), this descriptive-cross-sectional study involved analyzing 3563 samples of UTI agents collected from the microbiology department of the Central Diagnostic Laboratory and Shahid Sadoughi Hospital in Yazd. Identification of isolated bacteria utilized phenotypic methods, and antibiotic resistance assessments were performed using the disk diffusion method.Results: Among 3563 positive isolates, 80.4% originated from outpatients, while 19.6% were from inpatients. The most prevalent bacteria causing UTIs in both centers were Escherichia coli (57.8%), Klebsiella pneumoniae (9.7%), Staphylococcus aureus (9.1%), Streptococcus agalactiae (7%), and Acinetobacter (0.2%). Escherichia coli isolates exhibited the highest antibiotic resistance, particularly against amoxicillin-clavulanate (62.9%) and nalidixic acid (61.9%). In hospitalized patients, resistance to ampicillin (86%) and cotrimoxazole (72%) was notable, with over half of these isolates displaying ESBL positivity.Conclusion: Given the varying distribution of antibiotic resistance among UTI-causing isolates in both inpatient and outpatient settings, understanding antibiotic resistance patterns in diagnostic-treatment centers across diverse geographical areas is imperative.
Microbiology
Hamidreza Baghani Aval; Mehran Ekrami Toroghi; Faezeh Haghighi; Yaser Tabarraie
Volume 25, Issue 5 , November and December 2018, , Pages 687-693
Abstract
Background: Urinary tract infection is the most common infectious diseases and increasing resistance to antimicrobial agents in bacteria is a major problem around the world in treatment of urinary infections. This study was conducted to identify causative agents of urinary tract infection and to determine ...
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Background: Urinary tract infection is the most common infectious diseases and increasing resistance to antimicrobial agents in bacteria is a major problem around the world in treatment of urinary infections. This study was conducted to identify causative agents of urinary tract infection and to determine their susceptibility to antibiotics in hospitalized and out patients referred to the Vase’ee Hospital in Sabzevar.Methods: This descriptive cross-sectional study was performed on 256 individuals hospitalized and out patients older than eighteen age in the Sabzevar Vase’ee hospital. Identification of bacteria was performed using biochemical tests and their susceptibility was determined by disk diffusion method. The data were analyzed using t-test, Chi-square and Fisher’s exact test with percentage error 5%.Results: Of 256 patients, 59.7 % and 40.3% were female and male, respectively. The most frequently isolated pathogen were Escherichia coli (50.8%), Klebsiella (17.6%), Coagulase-Negative Staphylococci (15/62%), Enterobacter (7.8%). E. coli as most common pathogen of urinary tract infections showed the most resistance to ampicillin and the least resistance to Imipenem indicated. In total, regardless of the type of bacteria, the highest resistance was against amoxicillin and the lowest resistance was against Imipenem.Conclusion: Considering the frequency of urinary tract infections and in order to prevent serious complication, a survey of regional resistance pattern and timely treatment can control development of resistant bacteria.