immunology & Biochemistry
mahsa saeedpour; mohamad fazilati; zolfaghar lotfi
Abstract
Introduction: The COVID-19 pandemic, caused by the coronavirus, has emerged as one of the most pressing healthcare challenges of this century. The role of laboratory data in diagnosing severe forms of COVID-19 remains inconclusive. This research aimed to find ways to quickly prevent COVID-19.Materials ...
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Introduction: The COVID-19 pandemic, caused by the coronavirus, has emerged as one of the most pressing healthcare challenges of this century. The role of laboratory data in diagnosing severe forms of COVID-19 remains inconclusive. This research aimed to find ways to quickly prevent COVID-19.Materials and Methods: This research involved 43 COVID-19 patients monitored from March 2022 to May 2022 at the Mehregan Private Center in Khuzestan Province. Hematological and biochemical tests of the patients were performed. Measurements of D-dimer and Interleukin-6 were performed using the Biotek ELX 800TS analyzer, while fibrinogen levels were determined through the Clauss coagulation method. Data analysis was carried out using SPSS version 22 and GraphPad Prism version 9.Results: There is a significant difference in the levels of interleukin 6, D-Dimer, and fibrinogen, which was equal to 0.0001 (P<0.05). Threshold level and area under the receptor operating characteristic curve (ROC) interleukin-6 was 20.06 pg/ml and 0.837, D-dimer 952.5 ng/ml and 0.929, and fibrinogen was 206.5 mg/dL and 0.768, respectively. The specificity and sensitivity of predicting the severity of COVID-19 interleukin 6 were 67.44% and 100%, D-dimer 60.47% and 97.67%, and fibrinogen 53.49 % and 95.35%, respectively. Interleukin-6 and D-dimer had the highest specificity and sensitivity for early prediction of the severity of COVID-19, but for fibrinogen, this level was not as obvious as the other two factors.Conclusion: D-dimer and interleukin-6 had more pronounced effects on the severity of this disease, while fibrinogen had a lower impact.
Vahid Sari Sarraf; Mehdi Soleimani; Alireza Shamsoddini; Sirvan Atashak; Amir Amini; Behzad Bazgir; Amideddin Khatibi
Volume 22, Issue 1 , March and April 2015, , Pages 17-26
Abstract
Background: Fibrinogen (Fib) as a separate factor and influencing the risk of Cardiovascular is associated with the development of coronary heart disease. On the other hand, intense exercise increases the rate of early heart attacks. Due to the increased risk of abnormal clotting of blood vessels by ...
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Background: Fibrinogen (Fib) as a separate factor and influencing the risk of Cardiovascular is associated with the development of coronary heart disease. On the other hand, intense exercise increases the rate of early heart attacks. Due to the increased risk of abnormal clotting of blood vessels by intense exercise and the role of fibrinogen in cardiovascular diseases, strategies such as cocoa consumption has become more widespread. Materials and Methods: in a one-group double-blind experimental study, 11 elite male karateka (mean age: 21±2 years; height: 176.96± 3.41 cm) were participated randomly in two consecutive weeks (first week: placebo: six subjects and cocoa: five subjects, second week: placebo: five subjects and cocoa: six subjects) of exhaustive exercise (Bruce). Each athlete, after the first stage of blood sampling, the bottles contained placebo and cocoa into the mg.kg-1 5 will consume and two hours later did the Bruce test. Therefore, each athlete did the test tow order (1- after placebo consumption, 2- after cocoa consumption). Immediately before the test, immediately after and one hour after the test, a blood sample in the second, third and fourth were taken. Differences were examined using a two-factor analysis of variance (ANOVA) with repeated measures as appropriate. Results: Significant differences in fibrinogen levels during different stages of the cocoa consumption were not observed. These results indicate no effect of cocoa consumption on indicators of fibrinogen (P