Microbiology
maryam alsadat zarei; Mahboubeh Madani
Volume 25, Issue 1 , May and June 2018, , Pages 151-160
Abstract
Background: Teucrium polium is a medicinal plant which species have been used for over 2000 years in traditional medicine. The aim of this study was evaluation of the effect of ethanolic extract of Teucrium polium on Candida glabrata colonization in mice tissue. Material and Method: The study was performed ...
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Background: Teucrium polium is a medicinal plant which species have been used for over 2000 years in traditional medicine. The aim of this study was evaluation of the effect of ethanolic extract of Teucrium polium on Candida glabrata colonization in mice tissue. Material and Method: The study was performed on 90 mature male mices (9 per group), that were devided into 10 groups: normal, placebo, 3 treatment group (candida- extract), control positive (Candida glabrata) and control negative (extract). Treatment groups were received 50,100 and 200 mg/kg dosages of extract for 20 days (every other day) by intraperitoneal injection. At the end of injections, homogenized liver, spleen and kidney were cultured on SDA medium and then colony count were performed. Results: The results showed, that liver in 100 mg/kg, spleen and kidney in 200mg/kg haven’t any yeast. Discussion and Conclusion: According to the results, Teucrium polium extract, perhaps can stimulat the immunity against Candida glabrata. Keywords: Teucrium polium, Candida glabrata, liver, spleen, kidney
Banafsheh Ranjbar; Iran Poraboli
Volume 21, Issue 3 , July and August 2014, , Pages 370-378
Abstract
Background: With respect to antioxidant, antihyperglycemic and antihyperlipidemic properties of Daucus carota seeds extract in improvement diabetes mellitus, in this study, effects of this extract on renal function indicators and liver function enzymes were investigated in diabetic male rats.
Materials ...
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Background: With respect to antioxidant, antihyperglycemic and antihyperlipidemic properties of Daucus carota seeds extract in improvement diabetes mellitus, in this study, effects of this extract on renal function indicators and liver function enzymes were investigated in diabetic male rats.
Materials and Methods: Diabete type 1 was induced in male wistar rats weighting 200-250g by injection of 70 mg/kg, i.p of streptozotocin. Before this and 5 days postinjection fasting blood samples were collected for measurement of serum levels of glucose and liver enzymes (AST, ALT) and kidney indicators(urea, creatinine , uric acid). Diabetes was confirmed in rats having FBS above 250 mg/dL. Diabetic animals were devided to 10 groups received 100, 200, 300 mg/kg extract, 0.5 mL distilled water and 600µg/kg glibenclamide daily for 3 and 14 days individually by gavage. After 3 and, 14 days rats sacrified and fasting blood samples were collected and above serum parameters were measured with commertial kits by spectrophotometery
Results: Administration of different doses of D. Carota seeds extract for 3 and 14 days did not increase serum levels of renal indicators or liver enzymes. Also administration of extract (300 mg/kg) for 3 days significantly decreased urea and for 14 days decreased creatinine serum level. Also administration of extract at doses 100, 300 mg/kg for 3 days decreased AST and at 200 mg/kg for 14 days decreased ALT serum levels.
Conclusion: Using Daucus carota seeds extract for 3 or 14 days in remedy diabetes mellitus complications had no hepatotoxicity or renal damage.