Physical Education
shila Nayebi far; Elham Ghasemi
Volume 28, Issue 1 , January and February 2021, , Pages 106-114
Abstract
Introduction: The assessment of changes in liver Aminotranspherases and Insulin resistance following 4 weeks of exercise trainings have been of great importance in order to prevent liver diseases. The purpose of present study is to determine the effect of 4 weeks of high intensity interval trainings ...
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Introduction: The assessment of changes in liver Aminotranspherases and Insulin resistance following 4 weeks of exercise trainings have been of great importance in order to prevent liver diseases. The purpose of present study is to determine the effect of 4 weeks of high intensity interval trainings together with ginger on serum levels of liver enzymes and insulin resistance in pioneer football players. Materials and Methods: In this semi-experimental study, 46 football pioneer men (40-50 years) were selected according to selective and on purpose sampling, and were divided into 4 groups of Ginger+Training, Gnger, Training+placebo and control. The training groups performed high intensity trainings for 4 weeks with 90% HRmax while supplementation groups consumed 3×1000 mg ginger capsules daily. Blood sampling was done before and 48 hours after the intervention in fasting state. Data were analyzed using Shapiro-wilk, Two way ANOVA and Tukey post hoc tests in p < 0.05 significant level. Results: 4 weeks of ginger and HIIT decreased HOMA, ALT, AST, Glucose, Insulin, weight, WC and BMI significantly in experimental groups (Ginger, Train-Ginger, Train-placebo) compared to pretest (p≤0.05). The mean changes in mentioned indices showed better improvements in ginger+training group compared to other groups (p≤0.05). Conclusion: It seems that ginger intake together with high intensity interval exercises is an efficient factor in non-alcoholic fatty liver prevention and improvement by augmentation in fat metabolism through putting desirable results on serum liver enzymes, insulin resistance and body composition in pioneer football men players.
immunology & Biochemistry
Farnosh Anoosha; Bagher Seyedalipour; Ali Taravati; Monireh Movahedi
Volume 25, Issue 5 , November and December 2018, , Pages 649-658
Abstract
Background & Objectives: The toxicity of metals and their compounds is determined by their physicochemical properties. Thus, metals may compete for the biological binding sites and lead to incorrect function of biochemical macromolecules. The aim of this study was to investigate Ni NPs toxicity in ...
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Background & Objectives: The toxicity of metals and their compounds is determined by their physicochemical properties. Thus, metals may compete for the biological binding sites and lead to incorrect function of biochemical macromolecules. The aim of this study was to investigate Ni NPs toxicity in compared to Nickel chloride on liver enzyme activity and the histopathological changes of liver tissue in male wistar rats.Materials and Methods: In this experimental study, 48 male rates were divided into six experimental groups and one control group and one sham group (n=6). Experimental groups received Ni NPs and nickel chloride with concentration of 5, 15 and 25 mg/ kg by intraperitoneal injection. At the end of 7th day, blood and liver specimen was collected for analysis. Assay of the activity of liver enzyme and histopathological study were performed. Data were analyzed using ANOVA and Tukey test. Results: Enzyme activities of AST and ALP in different doses of Ni NPs and nickel chloride and LDH activity in different doses of nickel chloride showed significant changes in the studied groups (p > 0.05). Histopathological study of liver were revealed dose dependent changes in rats treated with nickel chloride and nanoparticles compared to the control group. Some of the changes including necrosis, congestion, apoptosis and steatohepatitis was observed after exposure to different doses.Conclusion: Increasing of concentration liver enzymes and histopathological changes confirms the toxicity of Ni NPs and nickel chloride
Banafsheh Ranjbar; Iran Poraboli
Volume 21, Issue 3 , July and August 2014, , Pages 370-378
Abstract
Background: With respect to antioxidant, antihyperglycemic and antihyperlipidemic properties of Daucus carota seeds extract in improvement diabetes mellitus, in this study, effects of this extract on renal function indicators and liver function enzymes were investigated in diabetic male rats.
Materials ...
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Background: With respect to antioxidant, antihyperglycemic and antihyperlipidemic properties of Daucus carota seeds extract in improvement diabetes mellitus, in this study, effects of this extract on renal function indicators and liver function enzymes were investigated in diabetic male rats.
Materials and Methods: Diabete type 1 was induced in male wistar rats weighting 200-250g by injection of 70 mg/kg, i.p of streptozotocin. Before this and 5 days postinjection fasting blood samples were collected for measurement of serum levels of glucose and liver enzymes (AST, ALT) and kidney indicators(urea, creatinine , uric acid). Diabetes was confirmed in rats having FBS above 250 mg/dL. Diabetic animals were devided to 10 groups received 100, 200, 300 mg/kg extract, 0.5 mL distilled water and 600µg/kg glibenclamide daily for 3 and 14 days individually by gavage. After 3 and, 14 days rats sacrified and fasting blood samples were collected and above serum parameters were measured with commertial kits by spectrophotometery
Results: Administration of different doses of D. Carota seeds extract for 3 and 14 days did not increase serum levels of renal indicators or liver enzymes. Also administration of extract (300 mg/kg) for 3 days significantly decreased urea and for 14 days decreased creatinine serum level. Also administration of extract at doses 100, 300 mg/kg for 3 days decreased AST and at 200 mg/kg for 14 days decreased ALT serum levels.
Conclusion: Using Daucus carota seeds extract for 3 or 14 days in remedy diabetes mellitus complications had no hepatotoxicity or renal damage.