immunology & Biochemistry
Maryam Khalesi
Volume 25, Issue 2 , May and June 2018, , Pages 251-258
Abstract
AbstractBackground: Physical activity and exercise along with nutrition and hygiene, are major factors in prevention of diseases. Due to increase in pulmonary disease prevalence in recent decades and the role of oxidative stress in the pathogenesis of these diseases, the purpose of this study was to ...
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AbstractBackground: Physical activity and exercise along with nutrition and hygiene, are major factors in prevention of diseases. Due to increase in pulmonary disease prevalence in recent decades and the role of oxidative stress in the pathogenesis of these diseases, the purpose of this study was to determine the effect of a period swimming exercise on Sirtuin 1 (Sirt1) and Forkhead box O3 (FoxO3a) genes expression in lung tissue of wistar rats. Materials and Methods: Twenty wistar rats with the weight of 102 ± 23 g randomly divided into two groups: exercise (n=10) and control (n=10). The exercise protocol included three months of swimming exercise (5 times per week) which begun from 25 minutes in the first week (4 liters per minute) and reached to 60 minutes (10 liters per minute) in the final week. Real time- PCR method was used to assess the genes expression of Sirt1 and FoxO3a in lung tissue. Kolmogorov-Smirnov test was used to test the normality and Independent t test was used to compare the group (α
Ali Jalalvand; Ali Heidarianpour; Javad Almasi
Volume 20, Issue 3 , September and October 2013, , Pages 373-379
Abstract
Background: Aerobic exercise stimulates the release of β- endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist’s opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period.
The purpose of this study ...
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Background: Aerobic exercise stimulates the release of β- endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist’s opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period.
The purpose of this study was investigated acute effects of swimming exercise on common behavior following withdrawal syndrome in morphine-dependent rats.
Method: in this experimental study Male Wistar rats (250±20 g, N=24) in two group (control addiction, exercise trained addiction) were addicted by morphine sulfate 0.4 mg/ml (for 21 days) and animals were submitted to swimming training for 8 weeks;they initially swim 60 min for 3 weeks, then 90 min 2 weeks, finally 120 min for 3 weeks. At the end of each stage of exercise protocol we inject naloxan hydrochloride (3mg/kg.ip). Behavioral symptoms (such as jumping, tearing, teeth chattering, diarrhea, and body tremors) were measured based on 45-minute in addicted animal. Analysis of variance with repeated measures (with the software SPSS) was used to analyze the data.
Results: Our data showed that swimming exercise after 5 and 8 weeks acutely decreased withdrawal sign (p