Mir Hadi Khayyat Nori; Seyyedeh Zahra Mosavi; Saeed Abbasi Maleki; Farid Abbasi Maleki; Ghader Najafi
Volume 20, Issue 4 , January and February 2014, , Pages 408-415
Abstract
Background and Purpose: It showed that antidepressants may reduce the abuse potential of opioid. In other hand, studies showed avena sativa has antidepressant and sedative properties. So the aim of this study was to investigate the effect of ethanolic extract of Avena sativa on morphine withdrawal signs ...
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Background and Purpose: It showed that antidepressants may reduce the abuse potential of opioid. In other hand, studies showed avena sativa has antidepressant and sedative properties. So the aim of this study was to investigate the effect of ethanolic extract of Avena sativa on morphine withdrawal signs in male mice.
Material and Methods: In this experimental study forty male NMRI mice (20-30 g) were randomly divided into 5 groups of 8: control groups received morphine and normal saline (10ml/kg) and other groups received ethanol (3%) and different doses of ethanolic extract of Avena sativa (50,100 and 200mg/kg).Morphine dependency was induced using a four- day schedule method with 50, 50, 75 and 50 mg/kg dosing respectively. In fourth day 2 hours after single dose of morphine, naloxone was injected (5 mg /kg) and withdrawal signs were recorded with number of jumping and diarrhea, grooming, wet dog shake, teeth chattering, writing, climbing as scores of 0 to 3 during 30min.The data were expressed with one-way ANOVA for quantities and Mann-Whitney U test for qualities data’s and they were analyzed with SPSS 15 and P values less than 0.05 were considered significant.
Results: The present study findings showed that all doses of ethanolic extract of Avena sativa compared to control group, significantly and dose- dependently decrease the number of jumping in morphine dependent mice (56.12±6.46, 40.0±5.33 and 31.5±2.5 respectively)) P
Ahmad Taghavi Rafsanjani; SeyyedAli Haeri Rohani; Aliasghar Porshanazari; Ali Shamsizadeh; Mohammad Allah Tavakkoli
Volume 20, Issue 3 , September and October 2013, , Pages 347-358
Abstract
Background and purpose: Morphine addiction and morphine withdrawal syndrome are of main problems in human societies. In the present study, effect of nicotine on the strength of physical and psychological dependency, produced by single and repeated doses of morphine, was investigated.
Material and method: ...
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Background and purpose: Morphine addiction and morphine withdrawal syndrome are of main problems in human societies. In the present study, effect of nicotine on the strength of physical and psychological dependency, produced by single and repeated doses of morphine, was investigated.
Material and method: Male wistar rats were dependent to morphine with single and repeated dose protocols. In the single dose protocol, rats received only one dose of morphine and 24h later were given Naloxone. In the repeated dose protocol, rats received incremental doses of morphine for 7 days and 24h after the last dose (8th day) were given Naloxone. In the single dose protocol, rats were given one dose of nicotine 30 min before Naloxone. However in the repeated doses they received nicotine 15 min before morphine for 4 days from 4th day to 7th day. 5 min after Naloxone each rat′s behavior was captured for 30 min. then physical and psychological signs of withdrawal syndrome were recorded.
Results: Results showed that injection of repeated and even single dose of morphine can produce dependency. Nicotine consumption attenuated strength of withdrawal syndrome signs, specially increasing weight excrement and total withdrawal score in single dose protocol and weight excrement increasing, weight decreasing, place aversion, and total withdrawal score in repeated dose treatment.
Conclusion: Based on our data, even a single dose of morphine can produce dependency in rats. Conversely, Nicotine consumption attenuates strength of withdrawal syndrome signs.
Ali Jalalvand; Ali Heidarianpour; Javad Almasi
Volume 20, Issue 3 , September and October 2013, , Pages 373-379
Abstract
Background: Aerobic exercise stimulates the release of β- endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist’s opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period.
The purpose of this study ...
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Background: Aerobic exercise stimulates the release of β- endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist’s opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period.
The purpose of this study was investigated acute effects of swimming exercise on common behavior following withdrawal syndrome in morphine-dependent rats.
Method: in this experimental study Male Wistar rats (250±20 g, N=24) in two group (control addiction, exercise trained addiction) were addicted by morphine sulfate 0.4 mg/ml (for 21 days) and animals were submitted to swimming training for 8 weeks;they initially swim 60 min for 3 weeks, then 90 min 2 weeks, finally 120 min for 3 weeks. At the end of each stage of exercise protocol we inject naloxan hydrochloride (3mg/kg.ip). Behavioral symptoms (such as jumping, tearing, teeth chattering, diarrhea, and body tremors) were measured based on 45-minute in addicted animal. Analysis of variance with repeated measures (with the software SPSS) was used to analyze the data.
Results: Our data showed that swimming exercise after 5 and 8 weeks acutely decreased withdrawal sign (p