Psychology
Mahshid Taherzadeh; Mahgol Tavakoli
Volume 27, Issue 4 , November and December 2020, , Pages 560-567
Abstract
Introduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with an unknown etiology. The disease affects several organs such as central nervous system. The purpose of this study was to assess memory profile (working, visual and auditory) in SLE patients and healthy individuals.
Materials ...
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Introduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with an unknown etiology. The disease affects several organs such as central nervous system. The purpose of this study was to assess memory profile (working, visual and auditory) in SLE patients and healthy individuals.
Materials and Methods: Thirty SLE patients and 30 healthy individuals were selected by the convenience sampling method. The sample was evaluated by Letter-Number Sequencing Test, Rey auditory verbal learning test (RAVLT) and Visual Memory test (Wechsler Memory III subscale). Data were analyzed by the univariate analysis of variance, multivariate analysis of variance and the Mann- Whitney U Tests.
Results: The results revealed a significant difference (p<0/005) between the two groups in working memory. There were no significant differences between SLE patients and healthy individuals in terms of immediate auditory memory and immediate visual memory. The results showed the significant differences between two groups in delayed visual memory (free recall and recognition) (p<0/02) and delayed auditory memory (free recall and recognition) (p<0/04).
Conclusion: Memory of patients diagnosed with Systemic Lupus Erythematosus, especially working, visual and auditory memory dimensions was be affected by neurological deficits related to the illness, which makes early neuropsychological assessments and related rehabilitation programs even more vital.
Physiology & Pharmacology
Fatemea Seyf; Seyed Ebrahim Hosseini
Volume 26, Issue 1 , March and April 2019, , Pages 46-51
Abstract
Background:Memory and learning are one of the most complex brain functions and a mechanism for encoding, storing and recalling learned information. Due to the prevalence of learning disabilities, especially in older adults, the present study aimed to investigate the effect of hydroalcoholic extract of ...
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Background:Memory and learning are one of the most complex brain functions and a mechanism for encoding, storing and recalling learned information. Due to the prevalence of learning disabilities, especially in older adults, the present study aimed to investigate the effect of hydroalcoholic extract of chamomile on avoidance memory levels in rats. Materials and Methods:In this experimental study, 48 adult male rats were divided into 6 groups: control, control 1 (treatment with normal saline) and control 2 (Shuttle Box) and three experimental groups receiving 200,100, and 400 mg/kg hydroalcoholic extract of chamomile by intraperitoneal injections. All of them were prescribed for 15 days. In this study, the Shuttle Box was used to measure memory and learning. The latency of entering and the time of remaining in a dark chamber of the Shuttle Box were recorded. The results were analyzed by ANOVA and Tukey tests using the SPSS-22 software. Results:The significance level of data was considered as p≤0.05. The results showed that doses of 200 and 400 mg/kg chamomile extract significantly increased the latency of entering the dark chamber and also doses of 100, 200, and 400 mg/kg chamomile extract significantly reduced the time of remaining in the dark chamber of the Shuttle Box in the remembering phase at the level of P≤0.001 compared to the control group. Conclusions: The results of this study showed that chamomile extract strengthens avoidance memory in rats. This effect is probably due to flavonoids, antioxidants and phytoestrogens.
Physiology & Pharmacology
Neda Moulaei; Mehdi Sadegh; Mohammad Reza Palizvan; Mahdieh Mondanizadeh; Narges-al-sadat Haeri
Volume 24, Issue 1 , March and April 2017, , Pages 17-27
Abstract
Background & Objectives: According to the increasing opioids abuse between women and pathophysiological effects of chronic exposure of opioids on mothers which might indirectly affect their offspring, herein, consequences of chronic morphine consumption and its withdrawal before the gestation was ...
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Background & Objectives: According to the increasing opioids abuse between women and pathophysiological effects of chronic exposure of opioids on mothers which might indirectly affect their offspring, herein, consequences of chronic morphine consumption and its withdrawal before the gestation was investigated on spatial memory, avoidance memory and vulnerability to morphine intake in offspring of first generation.
Materials & Methods: Twelve female Wistar rats were randomly divided into two groups. Morphine mothers group received morphine solution (0.4 mg/ml) for two months. Control mothers group received tab water. One month after stopping morphine consumption, mating was occurred. After the parturition, offspring was divided in separated male and female groups and was used as the target groups of the study. Spatial memory through Water Maze, avoidance memory through Shuttle Box and vulnerability to morphine intake through voluntary consumption of morphine solution were investigated.
Results: Mean of morphine solution consumption in male and female offspring of morphine mothers was significantly higher in compare to male and female offspring of control mothers (P<0.05). Results of learning in Water Maze revealed that male offspring of morphine mothers significantly spent more time and distance to find the platform in compare with male offspring of control (P<0.01). Also, in retention test, male offspring of morphine mothers cross the location of platform significantly fewer than male offspring of control (P<0.001). There was no significant differences in avoidance learning between experimental groups (P<0.05).
Conclusion: Our study revealedchronic morphine consumption before the gestation causesdamage of spatial memory in male offspring and also increases vulnerability to opiate intake of male and female offspring.
Mahmud Rafieian; Mohammadreza Hojjati; Fatemeh Taji
Volume 19, Issue 3 , September and October 2012, , Pages 258-266
Abstract
Background: Hyoscyamus niger has many different therapeutic effects, such as anti-convulsive and sedative effects. In this study, we tried to evaluate the eventual effect of hydro-alcoholic extract of Hyoscyamus niger on spatial learning and memory in mice using Morris water maze task. Materials and ...
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Background: Hyoscyamus niger has many different therapeutic effects, such as anti-convulsive and sedative effects. In this study, we tried to evaluate the eventual effect of hydro-alcoholic extract of Hyoscyamus niger on spatial learning and memory in mice using Morris water maze task. Materials and methods: In this study, 23 mice were randomly divided into one control group and two experimental groups. The control group received normal saline and the experimental groups received hydro-alcoholic extracts of Hyoscyamus niger (1 or 2 mg/kg, i.p.). At first, saline or extracts were injected daily (7 days) and then spatial learning was evaluated for 5 consecutive days. For evaluating short-term memory, two probe-trial experiments were performed. Finally, data were analyzed using one-way ANOVA, followed by Tukey’s test. Results: Results obtained from day 3 and day 4 of the learning period showed a significant reduction in learning the water maze task in the experimental group (2 mg/kg) compared with the control group (p