Human Baharvahdat; Payam Sasannejad; Mahmud Mohammadzade Shabestari; Farzad Fazeli
Volume 24, Issue 6 , March and April 2018, , Pages 13-18
Abstract
Background & Objectives: Several studies confirmed that early recanalization of intracranial arteries during ischemic strokes result in better recovery of these patients after three months of treatment. Materials & Methods: Recanalization of cerebral arteries is performed using intravenous tPA ...
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Background & Objectives: Several studies confirmed that early recanalization of intracranial arteries during ischemic strokes result in better recovery of these patients after three months of treatment. Materials & Methods: Recanalization of cerebral arteries is performed using intravenous tPA or mechanical thrombectomy. Results: Intravenous tPA injection within 3 hours of ischemic stroke is associated with better outcome in three months follow-up. Intravenous tPA has less effect on large cerebral arteries, like internal carotid arteries. Recent studies showed that mechanical thrombectomy of large cerebral arteries within 6 hours of stroke onset is associated with better outcome three months after operation. Since 2015, mechanical thrombectomy has been entered in first-line of acute phase of ischemic stroke in several guidelines and countries. Mechanical thrombectomy included several different endovascular techniques, as thrombosuction and stent retrieval for clot removal. Conclusion: Understanding several these different techniques, thier benefits, and their safety could help better selection of suitable method for endovascular treatment of stroke patients.
Sara Jahangiri; Musa Al-Reza Tadayyonfar; Alireza Rahmani; Mohammad Hasan Rakhshani
Abstract
Objectives Constipation is a predominant gastrointestinal problem after the onset of stroke, which may increase intracranial pressure. Treatment of constipation includes using laxatives and fibers, which is associated with complications and limitations. Regarding the effect of probiotics to treat digestive ...
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Objectives Constipation is a predominant gastrointestinal problem after the onset of stroke, which may increase intracranial pressure. Treatment of constipation includes using laxatives and fibers, which is associated with complications and limitations. Regarding the effect of probiotics to treat digestive problems, the current study aimed at investigating the effect of probiotics on constipation in the patients with stroke admitted to Intensive Care Unit (ICU).Methods The current randomized clinical trial was conducted on 65 patients with stroke. Patients with nasal-gastric tube and absence of rejection in 3 consecutive days were enrolled to the study. They were randomly divided into 2 groups of intervention (n=33) and control (n=32); the frequency of their bowel movements were measured before the study. Subjects in the intervention group received a probiotic supplement every 12 hours; however, the ones in the control group received the only routine conventional treatment for a week. After a week, all subjects were assessed for the improvement of constipation. Data were analyzed by SAS software version 9.1 using Poisson regression model. Results In the intervention group, the mean number of bowel movements was more than once a day, 1.22, and in the control group it was 0.62 (P<0.0001).Conclusion The current study showed that probiotic supplement consumption increased the frequency of constipation in patients with stroke. Therefore, probiotics can be used to treat constipation in such patients.
Mahtab Gholizadeh; Rahim Akrami; Mosareza Tadayonfar; Roya Akbarzadeh
Volume 22, Issue 6 , January and February 2016, , Pages 955-964
Abstract
Background & Objectives: Stroke is a debilitating and chronic disease. Caring of a patient with stroke can affect caregiver’s life dimensions, especially their quality of life. This study aimed to evaluate the effect of patient care education on caregivers’ quality of life of stroke patient.
Materials ...
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Background & Objectives: Stroke is a debilitating and chronic disease. Caring of a patient with stroke can affect caregiver’s life dimensions, especially their quality of life. This study aimed to evaluate the effect of patient care education on caregivers’ quality of life of stroke patient.
Materials & Methods: This randomized field trial was performed on 120stroke patients who were hospitalized in Vasei hospital in Sabzevar in 2014. Research units were randomly assigned to two groups: intervention group (n=60) and control group (n=60).Both groups completed SF-36 questionnaire before and one month after education. Data analyzed through chi-square, wilcoxon, paired t-test and independent t-test with STATAsoftware(V.12) with 5% significant level.
Results: The results revealed that, one month after education, scores of quality of life was significantly higher in intervention group than control group. The most differences were in General Health (p=1.000), Role ofPhysical(p=1.000) and Role of Emotion (1.000).
Conclusion: Teaching caring to caregivers of stroke patients leaded to enhancement of knowledge and skill in caring of patients and, finally, increased their quality of life. So,the importance of teaching care skills to caregivers by nurses must be paid more attention than before.
Sohrab Hajizadeh; Mohammad Javan; Mohammadreza Bigdeli; Firozeh Alavian
Volume 19, Issue 3 , September and October 2012, , Pages 287-295
Abstract
Background: Recent studies have shown that normobaric hyperoxia is effective in the treatment of acute ischemia, a phenomenon called preconditioning. However, the exact mechanism of this kind of preconditioning in vivo is not known. In this study, the effect of intermittent normobaric hyperoxia on expression ...
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Background: Recent studies have shown that normobaric hyperoxia is effective in the treatment of acute ischemia, a phenomenon called preconditioning. However, the exact mechanism of this kind of preconditioning in vivo is not known. In this study, the effect of intermittent normobaric hyperoxia on expression of HIF1α in a stroke model was investigated. Materials and Methods: In this experimental study, rats were divided into 4 groups. Hyperoxia groups were exposed to 95% inspired oxygen for 4 h/day and 6 consecutive days. Oxygen concentration in the control groups was 21% (normoxia). After 24 h, rats in stroke groups were subjected to 60 min of right middle cerebral artery occlusion. After 24 h, reperfusion neurological deficit scores were assessed. The brain HIF1α levels were analyzed by Western blot. Statistical analysis was performed using two-way ANOVA, Bonferroni post-test, Fisher exact test, and GraphPad Prism 5 software. Results: The results of this study showed that HIF1α levels increased in stroke groups compared with normoxia groups, while the amount of protein in hyperoxia groups was not significantly different from normoxia groups. Significantly increased HIF1α levels were observed in hyperoxia stroke group. Also, hyperoxia improved neurological deficit scores from 8.83% down to 3.46%. Conclusion: Hydroxylation, instability, and degradation of HIF1α occurred following hyperoxia. In the stroke groups, lack of oxygen delivery to cells prevents hydroxylation and degradation of HIF1α. In hyperoxia stroke group, inflammatory cytokines with increased ROS can induce increased expression of HIF1α.
Ahmad Delbari; Reza Salman-Roghani; Seyyed Shahabeddin Tabatabae
Volume 19, Issue 2 , May and June 2012, , Pages 96-108
Abstract
Stroke is one of the most common neurologic disorders with the highest mortality, morbidity, and loss of activity. Its crude annual incidence rate in Iran is 113-149 per 100,000 population. Due to the relatively young population of our country and their aging in the near future, the stroke incidence ...
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Stroke is one of the most common neurologic disorders with the highest mortality, morbidity, and loss of activity. Its crude annual incidence rate in Iran is 113-149 per 100,000 population. Due to the relatively young population of our country and their aging in the near future, the stroke incidence will rise significantly. Despite prominent advances in neuroscience and the existence of some effective medications for controlling stroke in the hyperacute phase, one of the most promising therapeutic approaches for these patients is rehabilitation. In this review, we try to outline the principles of stroke rehabilitation, new advances, our experiences, opportunities, and obstacles in Iran, hoping to improve the level of knowledge and quality of care for one of the most demanding and disabled segments of the population.