Masoumeh Fakhr Taha; Arash Javeri
Volume 28, Issue 2 , May and June 2021, , Pages 259-273
Abstract
Introduction: Mesenchymal stem cells (MSCs) have been identified as an attractive source for cell therapy of damaged tissues. The multipotential differentiation capability, easy accessibility, low immunogenicity and significant role in wound healing physiology have led to the widespread use of these ...
Read More
Introduction: Mesenchymal stem cells (MSCs) have been identified as an attractive source for cell therapy of damaged tissues. The multipotential differentiation capability, easy accessibility, low immunogenicity and significant role in wound healing physiology have led to the widespread use of these cells for wound healing. In this review study, the role of mesenchymal stem cells in repair of skin wounds is discussed . Materials and Methods: This review was written based on findings from a search of the PubMed and Google Scholar databases between 1990 and 2020. Results: Mesenchymal stem cells have important roles at all stages of wound healing. These cells migrate to the site of skin damage and not only differentiate into the skin cells but also through paracrine signalling inhibit the immune and inflammatory responses, induce proliferation and differentiation of resident progenitor cells and result in angiogenesis, epithelialization and granule tissue formation. In the regeneration and maturation phase, the MSCs reduce scar formation and wound contraction and increase collagen expression and wound tensile strength. These cells alter their function based on the biomolecular properties of the lesion site, and create a wound-healing rather than fibrotic microenvironment .
Conclusion: Todays, significant advances have been made in the delivery of MSCs into healing wounds. These cells are delivered via intravenous or intradermal injection, or delivered with scaffolds, as a fibrin polymer spray or with hydrogels. In addition, the extracellular vesicles and conditioned medium of MSCs alone are effective. Future studies could lead to more effective strategies for the use of mesenchymal stem cells in wound healing . Received
N MEHDIKHANLOO; GH.R HASANZADEH
Volume 11, Issue 4 , January and February 2005, , Pages 6-12
Abstract
Purpose: The present study was designed to investigate the effect of compound of Brassica Oleracea L. and egg-white on burn wound (type 2) healing in Rat.
Methods and Material: 50 female rats were studied through dividing them to 5 groups of 10 rats. After general anesthesia with ketamin and xylazin ...
Read More
Purpose: The present study was designed to investigate the effect of compound of Brassica Oleracea L. and egg-white on burn wound (type 2) healing in Rat.
Methods and Material: 50 female rats were studied through dividing them to 5 groups of 10 rats. After general anesthesia with ketamin and xylazin (ip), an area of the back of rats was burned with red-hot 50 Rials coin and similar grade II burns were created. Control group received no medication. In the second group, the surface of wounds were covered daily with silver sulphadiazine. In the third group, the surface of wounds were covered daily with compound of cabbage extract and egg-white. In the fourth group, the surface of wounds were covered daily with compound of cabbage powder and egg-white and in the fifth group, the surface of wounds were covered daily with compound of fresh cabbage and egg-white. Rats were killed by ether at the end of 1,2,3 and 4 weeks and samples were taken from the wound region and were histologically assessed. Then the samples were coloured with Hematoxillin and Eosin and studied quantitatively.
Results: Results showed that after 4 weeks the healing of burn wounds in the group receiving cabbage extract and egg-white was faster and better than other groups. The wound healing in silver sulphadiazin group and cabbage powder group were similar. There were no significant differences between these groups with cabbage extract and egg-white group.
Conclusion: Administration of topical cabbage extract and egg-white once a day in second degree burn wounds enhances the healing. Nearly similar results were observed in the silver sulphadiazin group compared with cabbage extract and egg-white group.