Zahra Estaji; Bahman Jafari; Mohammadhasn Rakhshani; Maryam Hatami
Volume 22, Issue 2 , May and June 2015, , Pages 427-435
Abstract
Background & Purpose: Poor sleep quality is common among hemodialysis patients. On the other hand, hemodialysis patients are encountered with carnitine deficiency. L-carnitine is a dietary supplement that has various metabolic functions and decreases the complications during dialysis. The purpose ...
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Background & Purpose: Poor sleep quality is common among hemodialysis patients. On the other hand, hemodialysis patients are encountered with carnitine deficiency. L-carnitine is a dietary supplement that has various metabolic functions and decreases the complications during dialysis. The purpose of this study was to determine the effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients.
Materials & Methods: In this double blind randomized clinical trial, 59 qualified hemodialysis patients were gone under investigation in Imam Khomeini Hospital in Shirvan during 2013. Patients were divided into intervention and control groups by permutation blocking method. Patients in the intervention group received 500 mg of L-carnitine supplement twice a day, and the placebo group was similarly taking placebo for 12 weeks. Tools for data collection consist of demographic form and Pittsburgh Sleep Quality Index which were completed before and after the intervention. Data were analyzed with SPSS statistical software version 11.5 and using independent t-test, Mann-Whitney test, chi-square, Fisher, Wilcoxon tests, Analysis of Covariance and significance level of P0.05.
Results: Before intervention, the mean PSQI scores were 9.6±4.2 and 10.1±4.13, respectively in the drug group and the placebo group and, after the intervention, the scores were, respectively, 6.4±2/8 and 9/7±3/48 that showed significant differences in both groups, compared to baseline(P0.05). Also, The PSQI score decreased by 33% in the intervention group and by 3/9% in the control group. Based on the Pittsburgh Sleep Quality Index, the lower score demonstrates a better condition of sleep qualiy.
Conclusion: This study showed that oral L-carnitine supplementation can improve sleep quality in hemodialysis patients.
A MAKHLOGH; M JAMSHIDI; V MOKHBERI
Volume 13, Issue 1 , March and April 2006, , Pages 14-18
Abstract
Background and purpose: Hyperlipidemia is one of the most important cardiovascular risk factors in hemodialysis patients. As adequate amount of carnation is essential for fatty acids metabolism and prevention of hyperlipidemia, This research was conducted to study the effect of carnitine on serum lipids ...
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Background and purpose: Hyperlipidemia is one of the most important cardiovascular risk factors in hemodialysis patients. As adequate amount of carnation is essential for fatty acids metabolism and prevention of hyperlipidemia, This research was conducted to study the effect of carnitine on serum lipids in hemodialysis patients.
Methods and Materials: 20 patients with at least 3 months hemodialysis duration participated in this double-blind clinical trial. Randomly and equally, they were divided into two (case and control) groups. Cases received 1g carnitine and controls received placebo daily. Cholesterol and Triglyceride levels were measured prior to the study as well as 3 and 6 months after administration. SPSS package and ANOVA, t-test and chi-squre tests were used far analysis.
Results: There were not significant difference in mean of cholesterol and triglyceride levels in two groups as well as in repeated measurements. Also, no significaut changes were observed in each group 3 and 6 months after administration.
Conclusion: Carnitine did not have any effect on serum lipids in hemodialysis patients.