Original Article
Mohammad solimani farsani; mohammad fathi; zahra hemati; zinab gorgin
Abstract
Introduction: Exercise is a non-drug option to prevent or slow the progression of Alzheimer's. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus..
Materials and methods: 32 6-week-old rats were randomly divided into four groups: sham (SH), ...
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Introduction: Exercise is a non-drug option to prevent or slow the progression of Alzheimer's. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus..
Materials and methods: 32 6-week-old rats were randomly divided into four groups: sham (SH), Alzheimer's control (AC), training (T) and Alzheimer's training (AT). Alzheimer's was induced by injecting beta-amyloid into the hippocampus. The training program consisted of 20 swimming training sessions with increasing time. After the end of the intervention, the tissue of the Gastrocnemius muscle and hippocampus was removed and the expression of the desired proteins was measured by immunohistofluorescent staining method. Correlation test was used to check the changes of the studied indicators.
Findings: The results showed that the expression of NCAM, SEMA3A and Pfn1 proteins had a significant positive relationship with NACHRa7 (P=0.001) and a significant inverse relationship with NLRP1 (P≥0.05) and Dead Cells (P≥0.05). they had.
Conclusion: Hippocampal inflammation and Alzheimer's progression can be prevented by physical activity and strengthening the neuromuscular junction.
Original Article
Traditional medicine
Roghayeh Javan; Fatemeh Joleini; Seyed Majid Ghazanfari; Mahbubeh Neamatshahi; Maryam Karrabi; Rahil Mahmoodi
Abstract
Background
Androgenic alopecia is one of the most common hair loss problems in men and women. Based on the symptoms, this type of hair loss can be compared to "Sale" in Persian medicine texts. The aim of study is evaluation the relationship between temperament and androgenic alopecia in patients ...
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Background
Androgenic alopecia is one of the most common hair loss problems in men and women. Based on the symptoms, this type of hair loss can be compared to "Sale" in Persian medicine texts. The aim of study is evaluation the relationship between temperament and androgenic alopecia in patients referred to the skin clinic in 2019.
Materials and methods
The current study is a cross-sectional study was conducted on 164 patients with androgenic hair loss referred to the dermatology clinic. Patients were randomly selected. After collecting data, they were analyzed using SPSS 16 software.
Results:
According to the results, although the greatest extent of hair loss in all grades was in men with warm and more wet temperaments, the results of Fisher's test showed, there was no statistically significant relationship between the severity of hair loss and the type of temperament (hot and cold) in men (P=0.39 and 0.89). In women, the greatest extent of moderate to severe and severe hair loss was observed in cold temperament. The results of Fisher's test show that there is no significant relationship between the extent of hair loss and hot,, cold temperament (P=0.49) and dry and wet of temperament (P=0.97) in women.
Conclusion
Despite the numerical superiority of men with hot and wet temperament and women with cold and wet temperament, there was no significant relationship between them and hair loss. Further studies with larger sample sizes are recommended.
Keyword: Androgenic Alopcia, patterned hair loss, Persian Medicine, Temperament.
Original Article
Nursing
hajar Smaeelabadi; Roghaye Zardosht; elahe lal kheirkhah; Mojgan Ansari
Abstract
Introductio&Goal: As the fundamental cornerstone of patient care, nurses must adhere to nursing ethics standards accurately. This study aimed to design, implement, and evaluate a training program for observing ethical standards in nurses working in special care units.
.Materials and Methods:The required ...
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Introductio&Goal: As the fundamental cornerstone of patient care, nurses must adhere to nursing ethics standards accurately. This study aimed to design, implement, and evaluate a training program for observing ethical standards in nurses working in special care units.
.Materials and Methods:The required information was collected and analyzed through a questionnaire and an observational checklist among 76 nurses working in special care units in this semi-experimental method using available sampling method. The study involved dividing nurses into two groups: case and control. The intervention group received an educational program in the form of clinical scenarios as a training course in the continuous education system. Two months later, questionnaires and observation checklists were administered to both groups. Data from the intervention and control groups were collected for analysis.
Result: The mean and standard deviation of the questionnaire and checklist scores for the intervention group were 155.47 ± 13.34 and 143.23 ± 17.28 before training, and 165.62 ± 4.26 and 10.82 ± 10.82 after training, respectively. A significant difference was observed in the intervention group (p<0.001), with a mean score of 164.06. In the control group, there was no significant difference after the intervention (p < 0.05). The questionnaire and checklist scores after the educational intervention in both the control and intervention groups (p < 0.001)demonstrate the effectiveness of the education on the intervention group.
Conclusion: The study results indicate that designing an educational program based on ethical standards compliance levels, conducting needs assessments, and providing training courses can enhance nurses' moral performance.
Original Article
Anesthesiology
Hessamedin Babaei; Mahtab Ghasemi; Aref Arminfar; Leila Khojasteh; Shiva Shabanzadeh; Soheil Shahrami Rad; Afagh Zamen Ghadirli; Behrooz Yahyaei
Abstract
Background: One of the common drugs used in modern anesthesia, especially during pregnancy, is ketamine, which is used to control chronic pain by inhibiting the N-methyl-D-aspartate receptor. Therefore, in this study, we investigate the effects of injected ketamine on the histological changes of the ...
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Background: One of the common drugs used in modern anesthesia, especially during pregnancy, is ketamine, which is used to control chronic pain by inhibiting the N-methyl-D-aspartate receptor. Therefore, in this study, we investigate the effects of injected ketamine on the histological changes of the hearts of rats born to exposed mothers.
Method: This study was conducted as a laboratory experiment on 15 female Wistar rats. These rat were divided into three groups of 5 including control, short-term and long-term groups, and after induction of fertility, 10 baby rats were randomly selected from each group and subjected to cardiac tissue dissection and sampling.
Results: In the short-term dose group, cellular characteristics and heart tissue were normal, and no clear changes were observed compared to the control group, but in some areas, there were small intercellular spaces with a decrease in density. In the long-term dose group, a slight inflammatory process was seen in some areas, but there were no changes in the cells, cytoplasm, and nuclei.
Conclusion: Although the long-term exposure of mother rat to ketamine can cause mild inflammation and moderate hyperemia in the heart tissue of newborn rat, and the short-term exposure of mother rat to ketamine causes mild changes in heart muscle tissue like long-term exposure but these changes have not been noticeable.
Original Article
Psychology
Reza Asadi; Fatemeh Azizi Ganjehei; Seyed Mosa Tabatabaee
Abstract
Background: Cannabis is the most widely used drug in the world. The present study aimed to analyze the discriminant of cannabis use intensity based on attachment style, anger rumination, perceived social support, and life satisfaction
Materials and Methods: The present study was descriptive and causal-comparative. ...
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Background: Cannabis is the most widely used drug in the world. The present study aimed to analyze the discriminant of cannabis use intensity based on attachment style, anger rumination, perceived social support, and life satisfaction
Materials and Methods: The present study was descriptive and causal-comparative. The statistical population of the research included all cannabis users in the city of Arak. 90 people were selected by snowball sampling method. The data were collected from the Alcohol, Smoking, and Substance Involvement Screening Test (Hominiuk et al., 2008), the Adult Attachment Inventory (Bashart, 2011), the Anger Rumination Scale (Sukhodolsky et al., 2001), the Multidimensional Scale of Perceived Social Support (Zimet et al., 1988) and Satisfaction With Life Scale (Diener et al., 1985). Data analysis was done using the discriminant analysis method and SPSS-26 software.
Results: The results of the discriminant analysis showed that all three dimensions of the attachment style variable, the total score of anger rumination variable, family and friends components of the perceived social support variable, as well as the total score of this scale and the variable of life satisfaction, showed significant differences between the studied groups.
Conclusion: Considering the ability to differentiate research variables, they can be used to differentiate the intensity of cannabis use into three groups: lower risk, medium risk, and high risk.
Review article
nutrition
Elaheh Foroumandi; Akram Kooshki; Seyed Majid Ghazanfari
Abstract
Background: The present study was investigated the effects of different groups in the food pyramid on human health from the perspective of the Qur'an, hadiths and modern medicine in order to further prove the importance of the recommendations in these sources and their consistency with the latest ...
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Background: The present study was investigated the effects of different groups in the food pyramid on human health from the perspective of the Qur'an, hadiths and modern medicine in order to further prove the importance of the recommendations in these sources and their consistency with the latest scientific results.
Materials and methods: This comparative review study was conducted in two stages. First, the data related to the different food groups in the food pyramid that were mentioned in the Quran and hadiths were collected. Then, in the second step, the health effects of different food groups were investigated based on modern medicine by reviewing SID, MEDLINE, Scopus, PubMed and Google Scholar databases.
Results: Six food groups in the food pyramid are mentioned in the Holy Quran and hadiths, which are in line with modern medicine. Among the group of bread and cereals, the importance of receiving wheat, barley and rice has been mentioned. Also, among the fruits and vegetables, figs, pomegranates, apples, dates, and pumpkin, onion, garlic, and eggplant vegetables are emphasized. The recommendation to receive the meat group and its substitutes in balance, the milk and dairy group as well as honey can be seen in these databases, which is in line with modern medicine.
Conclusion: considering increasing awareness about religious teachings, one can better understand the type of nutrition and the amount of intake of many food items; therefore, everyone took a step towards improving the nutritional status and consequently the health of people.
Original Article
Physical Education
Azizeh Toghdori; Keyvan Hejazi; roya askari; , Najmeh Rahimi
Abstract
Background and Objective: Diabetes can be a life-threatening condition, and maintaining blood sugar levels, proper nutrition, and regular physical activity are crucial for controlling diabetes and preventing its complications. The present study aimed to investigate the effect of twelve weeks of resistance ...
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Background and Objective: Diabetes can be a life-threatening condition, and maintaining blood sugar levels, proper nutrition, and regular physical activity are crucial for controlling diabetes and preventing its complications. The present study aimed to investigate the effect of twelve weeks of resistance band training on the levels of spexin and insulin resistance indices in women with type 2 diabetes.
Materials and Methods: In this semi-experimental study, 22 women with type 2 diabetes were randomly divided into two groups: resistance band (n=11) and control (n=11). The exercise program consisted of 12 weeks, three sessions per week, and each session lasted for 45 to 60 minutes. One-way ANOVA with repeated measures was used for within- and between-group changes.
Results: The results showed that the interaction changes in serum spexin levels were significant between the experimental and control groups (p=0.012). However, no significant changes were observed in glucose (p=0.229), insulin (p=0.116), and insulin resistance index (p=0.178). Within-group changes in the insulin resistance index were significant (p=0.04). According to the Bonferroni post-hoc test, there was no significant difference in serum spexin level between pre-test and the eighth week (p=0.141) and between pre-test and the twelfth week (p=0.429).
Conclusion: Resistance band training, compared to the control group, significantly increased spexin and led to a considerable improvement in fasting glucose concentration, insulin, and insulin resistance index. Therefore, it is suggested that resistance band training can be implemented as a suitable alternative to home-based resistance training for individuals with type 2 diabetes.
Original Article
Psychology
Ebrahim Namani; Zeinab Abedinpour; Zahra bagheshani; naeimeh mogheiseh
Abstract
Background and Objective: Nurses always experience high levels of job burnout, which affects their psychological well-being and organizational commitment level. This study was conducted with the aim of investigating the mediating role of religious beliefs in the relationship between psychological well-being ...
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Background and Objective: Nurses always experience high levels of job burnout, which affects their psychological well-being and organizational commitment level. This study was conducted with the aim of investigating the mediating role of religious beliefs in the relationship between psychological well-being and organizational commitment with nurses' job burnout.
Materials and Methods: The present research method was descriptive and correlation type. The statistical population of this research included all the nurses of private hospitals in Mashhad in the summer of 2023, 200 of them, and they were selected by available sampling method. The data collection tool was Maslach's job burnout questionnaire (1981), Golriz and Baraheni's religious beliefs (1974), Allen and Meyer’s organizational commitment (1997) and Ryff's psychological well-being (1989). Findings were analyzed using Pearson's correlation test and path analysis, and Amos22 and SPSS22 software were used in all statistical analyzes of this research.
Results: The results showed that there is a significant negative relationship between mental well-being and job burnout (p-value <0.05); However, no significant relationship was found between organizational commitment and job burnout. Also, it should be added, religious beliefs played a mediating role in the relationship between psychological well-being and organizational commitment with job burnout (p-value <0.01).
Conclusion: Using the results, it can be concluded that the relationship between psychological well-being and organizational commitment with job burnout is not a simple linear relationship and religious beliefs can play a mediating role
Original Article
Psychology
fahimeh rezvani; farshid khosropoor; hamid molaei
Abstract
Abstract
Introduction: The presence of emotional problems in adolescents causes a decrease in their quality of life, which requires psychological interventions, including psychological immunization. The purpose of the present study was to determine the effectiveness of psychological immunization training ...
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Abstract
Introduction: The presence of emotional problems in adolescents causes a decrease in their quality of life, which requires psychological interventions, including psychological immunization. The purpose of the present study was to determine the effectiveness of psychological immunization training on the quality of life and emotional regulation of adolescents.
Research method: This research was a semi-experimental type of research (pre-test-post-test design with a control group). The statistical population of the research included all female students of the 10th grade of high school in Rafsanjan city in 1402, 30 people were randomly selected by available sampling method and divided into two experimental groups (15 people) and control by lottery. (15 people) were placed. Var et al.'s (1996) quality of life questionnaires and Garnevsky and Kraij's (2006) emotion regulation questionnaires were used. The training of psychological immunization program was carried out in 10 sessions of 60 minutes and twice a week on the experimental group and the control group did not receive any training. Analysis of covariance and SPSS version 24 software were used to analyze the data.
Results: The results of covariance analysis showed that there is a significant difference between the pre-test and post-test scores, and the psychological immunization program training increased the quality of life and improved emotion regulation in adolescents (P<0.01).
Conclusion: Since teenagers are psychologically very vulnerable, the training of the psychological immunization program can play a very effective role in increasing the quality of life and improving their emotional regulation.
Original Article
Nursing
Mostafa Rad; Farzaneh Hosseinpour; Mohammad Reza Armat
Abstract
Background: Colors and their effect on the human mind and body have been investigated in various ways, and patients admitted to the intensive care unit experience a lot of stress due to environmental factors and special treatment conditions. This study was conducted with the aim of comparing the effect ...
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Background: Colors and their effect on the human mind and body have been investigated in various ways, and patients admitted to the intensive care unit experience a lot of stress due to environmental factors and special treatment conditions. This study was conducted with the aim of comparing the effect of blue and green light with normal light on the vital signs and anxiety levels of patients admitted to the Coronary care unit (CCU)..
Materials and Methods: This clinical trial was conducted on 75 patients admitted to the CCU department of Imam Khomeini Hospital in Esfarayen North Khorasan in 2021-2022. Patients were randomly assigned to three groups of blue, green, and white light, and vital signs were measured every half hour, and patients' anxiety was measured twice (at the beginning and end of the study) using the Spielberger questionnaire. Data analysis was performed using repeated measures ANCOVA.
Results: The variables of pulse, breathing rate, blood pressure, temperature, and anxiety levels were not observed significant difference between the subjects of the intervention groups and the control group (p>0.05). In the intervention group with blue light, blood oxygen saturation level on the first and second day and the second and third showed a significant difference (p<0.05).
Conclusion: There was no difference between the effect of blue, green light and white light on the level of anxiety, breathing, blood pressure, temperature, and pulse rate; But blue light had an effect on blood oxygen saturation level. It is suggested to study more in this field.
Original Article
Psychology
mehrnaz goodarzian; Kourosh Mohammadi; Azita Amir fakhraei
Abstract
Introduction: Women with breast cancer are damaged in terms of the source of control related to health and metacognitive beliefs, which require therapeutic interventions. The present study was conducted with the aim of determining the effectiveness of acceptance and commitment therapy (ACT) on health-related ...
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Introduction: Women with breast cancer are damaged in terms of the source of control related to health and metacognitive beliefs, which require therapeutic interventions. The present study was conducted with the aim of determining the effectiveness of acceptance and commitment therapy (ACT) on health-related locus of control and metacognitive beliefs in women with breast cancer.
Materials and methods: The present study was a semi-experimental pre-test-post-test type with a control group. The statistical population consisted of women with breast cancer referring to health centers in Dezful city in 2019. 40 people were selected from the mentioned population using available sampling method and randomly replaced in two experimental (20 people) and control (20 people) groups. Treatment based on acceptance and commitment was implemented in 8 sessions of 90 minutes and once a week in the experimental group and the control group did not receive any intervention. Walston's (1994) locus of control questionnaires and Wells and Hutton's (1997) psychological beliefs were used. Data were analyzed using SPSS version 24 software and covariance analysis method.
Results: The results showed that the treatment based on acceptance and commitment in the post-examination stage had a significant effect on increasing the locus of control related to health and metacognitive beliefs in women with breast cancer (P<0.001).
Conclusion: According to the results of this research, this type of treatment can be used to reduce psychological problems and increase the source of control related to health and metacognitive beliefs in women with breast cancer.
Original Article
Physiology & Pharmacology
Mina Abroudi; Ghazaleh Dadashizadeh; saeideh sadat shobeiri; Azar Hosseini; omid gholami; Reza Ataee Disfani; Davood Mahdian; MARYAM KHOSROJERDI
Abstract
Background: Cancer is considered as an important global health problem. Chemotherapy drugs used in cancer treatment have side effects such as bone marrow suppression, hair loss, gastrointestinal lesions, drug resistance, neurological dysfunction and heart toxicity. Flavonoids are bioactive compounds ...
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Background: Cancer is considered as an important global health problem. Chemotherapy drugs used in cancer treatment have side effects such as bone marrow suppression, hair loss, gastrointestinal lesions, drug resistance, neurological dysfunction and heart toxicity. Flavonoids are bioactive compounds found in most plants and have beneficial effects on various cancerous tissues. Hesperidin is found as a flavonoid in the citrus family. In this research, the anticancer effects of hesperidin on different cancer cell lines, including adrenal medullary tumor (pheochromocytoma) (PC12), colon adenocarcinoma (SW48), prostate cancer (DU145) and esophageal squamous cell carcinoma (KYSE30) were investigated.
Methods: Cells were treated with different concentrations of hesperidin (0.75-100 μM) for 24, 48 or 72 hours, and cell viability was evaluated by MTT method. In addition, the expression of Bax, Bcl-2 and caspase-3 genes was measured using RT-PCR. Also, cell apoptosis was evaluated by flow-cytometry.
Results: The results showed that hesperidin prevents the proliferation of different cancer cells. Also, flow-cytometry results showed that hesperidin can increase cell apoptosis, which was confirmed by gene expression results. Hesperidin significantly decreased the expression of bcl-2 gene while increasing the expression of Bax and Caspase-3 (p<0.05).
Conclusion: It seems that hesperidin as a natural product can be used in the treatment of all types of human cancers in combination with chemical drugs.