Original Article
Mehdi Ranjbaran; Mina Chizari; Pegah Matori Pour
Volume 22, Special Issue , March and April 2016, Pages 1117-1125
Abstract
Background: Sexual dysfunction in women is common and is one of the factors of divorce and disintegration in families. The aim of this study was to determine the prevalence of female sexual dysfunction in Iran using a descriptive meta-analysis study. Materials and Methods: In this meta-analysis study, ...
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Background: Sexual dysfunction in women is common and is one of the factors of divorce and disintegration in families. The aim of this study was to determine the prevalence of female sexual dysfunction in Iran using a descriptive meta-analysis study. Materials and Methods: In this meta-analysis study, the databases of ISI Web of Knowledge, PubMed, Scopus, Google Scholar and interior databases were searched during 2001 to 2015. Between the studies with regard to the inclusion and exclusion criteria, 11 studies were selected. Heterogeneity assessed by Cochran’s Q statistic and I2 index. Cause of heterogeneity was evaluated using meta-regression model. Results: Total samples size in the 11 studies were 8248. Cochran’s Q statistic and I2 index revealed observable heterogeneity between studies (Q=552.70, P-value 2= 98.4). Overall prevalence of female sexual dysfunction based on the random effect model (Inverse Variance Method) was obtained 43.9% (95% CI: 35.0 – 52.8). Prevalence of desire, arousal, lubricating, orgasmic, satisfaction and pain disorders were 42.7 % (32.0-53.4), 38.5% (27.6-49.5), 30.6% (22.0-39.2), 29.2% (24.1-34.3), 21.6% (11.5-31.8) and 40.1% (31.8-48.3), respectively. Conclusion: This meta-analysis showed a comprehensive view about female sexual function in Iran. However, compared with other developing countries, Iran has a favorable situation. Considering the high prevalence of female sexual dysfunction, more epidemiological research for detection of affecting factors, intervention and preventive actions seem essential.
Review article
Mohammadreza Yeylaghi Ashrafi; Valiollah Dabidi Roshan
Volume 22, Special Issue , March and April 2016, Pages 1126-1138
Abstract
Background and purpose: The aim of the present study was to systematic review for the influence of aerobic and anaerobic exercise of the acute and chronic on selected markers of oxidative Stress based on the animal and human studies published in persian journals. Methods and Materials: This present was ...
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Background and purpose: The aim of the present study was to systematic review for the influence of aerobic and anaerobic exercise of the acute and chronic on selected markers of oxidative Stress based on the animal and human studies published in persian journals. Methods and Materials: This present was performed on articles published up to 1 August 2014. Databases such as Magiran, SID and Scholar Google searched for terms: Oxidative Stress, SOD, MDA, Exercise And Training. All the relevant Persian written articles were evaluated by two independent researchers and relevant articles with moderate and high qualities was selected for systematic review. Articles (of total 1163 articles) were evaluated by reading their title, abstracts and full text; 38 full text articles evaluated and only 22 of them fulfilled the inclusion criteria and entered the review. Results: In human studies it was found that regular aerobic exercises lead to a significant and non-significant increase in MDA values. On the other hand, a significant increase was detected in SOD values in the exercising group compared to the control group following 8 weeks of aerobic exercise. However, based on findings from animal research domain, it was found that implementation of at least 8 weeks of aerobic exercise is necessary for down regulation of MDA values and 6 weeks for up regulation of profit values. Conclusion: Present study indicates the lack of high-quality reports on the impact of regular aerobic or anaerobic exercises on resting levels or in response to a bout of intense exercise, especially on human subjects and the few reports of average quality did not also represent a homogeneous finding.
Review article
Yosef Jalal Abadi; Alireza Shirazi; Mohammadreza Ghavam Nasiri; Amir Al Davood; ِDaryoosh Sardari
Volume 22, Special Issue , March and April 2016, Pages 1139-1157
Abstract
Background & Objectives: One of the major causes of death in the world is cancer.Due to significant advances in molecular and cellular biology, previous approaches in cancer treatment have progressed, applying new strategies.Identification and use of chemotherapy and radiation sensitizers and their ...
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Background & Objectives: One of the major causes of death in the world is cancer.Due to significant advances in molecular and cellular biology, previous approaches in cancer treatment have progressed, applying new strategies.Identification and use of chemotherapy and radiation sensitizers and their effect on the further destruction of the cancer therapy.COX-2 enzyme inhibition with Celecoxib and the prevention of the restoration of this tumour.
Evidence Acquisition:The mechanism by which the cells are radiosensitized can increase the initial damage, inhibiting the restoration and redistribution of the cell cycle as well as blocking in the more radiosensitized zone.Enhanced response to treatment would be initiated by identifying enzymes that are involved in increasing tumour growth and followed by inhibiting tumour growth and restoration. COX-2 is one of the enzymes expressed highly in tumour growth. Inhibiting this enzyme will enhance the response rate of treatment followed by the death of tumour cells.
Results: There are five mechanisms that the COX-2 enzyme applies to develop tumours and increase the malignant phenotype of tumour cells.The drug inhibits the COX-2 enzyme through TNF-α signalling by nuclear transfer inhibition of growth factor.It also inhibits NF-KB transcription factor activation.Apoptosis inhibition is one of the mechanisms implemented by COX-2 that increases tumourigenesis.Cell cycle arrest at G1-S is one of the most sensitized areas to radiation. Studies in the field of pancreatic and ovarian carcinoma cells show cell cycle arrest at G1-S; the mechanism by which this arrest happens is not fully understood.
Conclusions: Celecoxib, as a COX-2 inhibitor that affects and inhibits some enzymes and creates changes in the cell cycle process, has the role of a radiosensitizer.Celecoxib prevents cancer. Celecoxib inhibits tumour growth delay and the amount is insignificant.Concomitant use of Celecoxib with chemotherapy and radiotherapy with a synergy that will further damage the cells during and after radiation therapy.
Review article
Erfan Ayyobi; Kamyar Mansouri; Mohammad Golmahi; Ozra Ramezan khani; Alireza Mosavi Jarrahi
Volume 22, Special Issue , March and April 2016, Pages 1158-1171
Abstract
Research development and information technology progress lead to generate big dataset with valuable information. In health research, with tracing people from different dataset like registries can provide valuable information about prognosis, prediction, discrimination, detection or etiology for many ...
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Research development and information technology progress lead to generate big dataset with valuable information. In health research, with tracing people from different dataset like registries can provide valuable information about prognosis, prediction, discrimination, detection or etiology for many outcomes without establishing costly studies. Extracting the knowledge from this potential information is applied using advanced methods such as data linkage or record linkage with deterministic or probabilistic algorithm. However, probabilistic linkage is computationally complex and not well understood by many researchers who may wish to apply it in their work. Therefore, the purposes of this review article is to introduce probabilistic record linkage methodology such as quality and standardization of dataset, determining the matching records from different dataset, calculating the matching weights and discrimination matched from unmatched record using a cut point. In follow, with a practical example the probabilistic record linkage methodology is introduced by cancer registry and mortality dataset.
Review article
Mehran Sohrabzadeh; Mohsen Niazi; Rostam Mennati; Aziz Kasani; Walieh Mennati
Volume 22, Special Issue , March and April 2016, Pages 1170-1179
Abstract
Background: The use of industrial drug such as methamphetamine ,reported asan important health problemin students and adolescents in around the world. It was regarded as a concerning event in the students by World Health Organization (WHO). Therefore, the aim of present study was determining prevalence ...
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Background: The use of industrial drug such as methamphetamine ,reported asan important health problemin students and adolescents in around the world. It was regarded as a concerning event in the students by World Health Organization (WHO). Therefore, the aim of present study was determining prevalence of methamphetamine in the Iranian male student using a meta-analysis study. Material and Methods: the present meta-analysis was conducted using random effect model. For the selecting studies on the prevalence of methamphetamine were searched in SID, Iranmedex, Magiran, Medlib, Pubmed, ISIand Scopus databases by three researchers from 2001 to2014. Then, were identified 69articles and after reviewing based on inclusion and exclusion criteria wereincluded10 articles in the study and was used from the random-effects model by CMA-2 software for analyzing data. Also, the heterogeneity was determined to Q,Ƭ2 and I2 coefficients. Results:The pooled effect size (prevalence)was obtained around 1.2% (CI 95%: 0.8-1.6). Also, in the subgroup analysis, the prevalence of amphetamine was attained 1.6% and 0.9%after and before 2010, respectively. Moreover, the indices related to heterogeneity were including; Q=6.38, I2=0.31 and T2=0.16. In addition, there was a significant association between age and the prevalence of methamphetamine (B=1.13, p=0.01) in the meta-regression analysis. Discussion: Although, the prevalence of methamphetamine was less than other drugs in the male students. But, the increasing prevalence of methamphetamine in the Iranian students, especially in male students, is as a serious warning to the authorities and families.
Review article
Hamid Moghaddasi; Reza Rabiei; Forogh Rahimi; Shirin Ayani
Volume 22, Special Issue , March and April 2016, Pages 1180-1191
Abstract
Background & Objective: The primary problem of diabetics is estimating the insulin dose in a way that blood glucose level is placed within the proper physiological scope in the body. However, due to the fact that insulin drug consumption can be very risky, new technologies, especially Clinical Decision ...
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Background & Objective: The primary problem of diabetics is estimating the insulin dose in a way that blood glucose level is placed within the proper physiological scope in the body. However, due to the fact that insulin drug consumption can be very risky, new technologies, especially Clinical Decision Support System (CDSS), have extensive use for blood glucose control. This study aims at examining the evolution of CDSSs for estimating insulin dose. Materials & Methods: In this review, scientific databases using a combination of sensitive keywords were searched out in articles published in accredited journals. Then, categorization and content analysis procedures were performed using scientific methods. Findings: In open loop control approach, the level of blood glucose is measured by the patient and dose of required insulin is determined by CDSSs based on Information Technologies with the inspection of a physician. However, in closed loop control approach the CDSS which is placed in Insulin pump, receives the level of blood glucose via the pump sensor and then determines the dose of required insulin. It is noteworthy that either of these approaches contains two different types. Conclusion: Though in modern society the development of open loop control systems based on Information Technologies seems more affordable and more possible, scientists are increasingly trying to make intelligent closed loop control systems with the impact of Nano equipment. Their purpose is to produce an Artificial Pancreas which can simulate natural pancreas activities to satisfy the patients' mutilation.