Document Type : Original Article
Authors
- Shirin Afhami 1
- Negin Esmailpour Bazaz 1
- Alireza Khoshnevisan 2
- Kourosh Sadeghi 3
- Mahmood Reza Sarzaeem 4
- Parastoo Amiri 5
- Ehsan Rahimpour 6
- Mahnaz Montazeri 7
1 Associate Professor of Infectious Disease, Department of Infectious Disease and Tropical Medicine, School of Medicine, Shariati Hospital, Tehran university of medical sciences, Tehran, Iran
2 Professor of Neurosurgery, Department Neurosurgery, School of Medicine, Shariati Hospital, Tehran university of medical sciences, Tehran, Iran
3 Assistant Professor of Clinical Pharmacy, Department Clinical Pharmacy, School of Pharmacy, Tehran university of medical sciences, Tehran, Iran
4 Associate Professor of Cardiovascular Surgery, Department General Surgery, Shariati Hospital, Tehran university of medical sciences, Tehran, Iran
5 Community Medicine Specialist, Iranian Research Center on Healthy Aging (IRCHA), Sabzevar University of Medical Sciences, Sabzevar, Iran
6 Plastic, Reconstruction and Aesthetic surgery fellow, Sina Hospital, Department of surgery, School of Medicine, Tehran University of medical sciences, Tehran, Iran
7 Assistant Professor of Infectious Disease, Department of Infectious Disease and Tropical Medicine, School of Medicine, Sina Hospital, Tehran university of medical sciences, Tehran, Iran
Abstract
Introduction: The rational use of antibiotic prophylaxis before surgery can reduce surgical site infection, microbial resistance, and economic burden. Therefore, the present study was carried out to optimize the use of antibiotic prophylaxis before surgery using a ready-made drug package prepared in the pharmacy of Dr. Shariati Hospital.
Materials and Methods: The current study is a semi-experimental intervention type, carried out in two stages before and after on 260 patients hospitalized in the heart surgery and neurosurgery departments of Dr. Shariati Hospital who were candidates for surgery and received antibiotic prophylaxis before surgery. A checklist containing patients ' information was completed before and after the preparation of antibiotic prophylaxis packages. Data were analyzed in spss18 software with descriptive and analytical statistics (p≤0.05).
Results: Before and after the optimization of antibiotic use, a statistically significant difference was observed in the two study groups regarding dosage, administration intervals, time, and duration of administration. (P<0.001) A 63.42% reduction in the number of doses of antibiotic prophylaxis was observed after the implementation of optimization. Also, there was a 57.33% reduction in the cost of antibiotic prophylaxis after the implementation of optimization.
Conclusion: The use of a ready-made drug package before surgery optimizes the use of antibiotic prophylaxis. Also, the economic burden caused by inappropriate use of prophylactic antibiotics for the patient and the hospital is significantly reduced with this method.
Keywords
Main Subjects
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