نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه قم، قم، ایران

2 دانشجو دکتری، گروه علوم ورزشی، دانشکده تربیت بدنی و علوم ورزش، دانشگاه مازندران، ایران

چکیده

زمینه و هدف: چاقی و اضافه‌وزن به یک معظل جهانی تبدیل شده است. چاقی در زنان ایرانی به‌شدت رو به افزایش است. متخصصان عقیده دارند که رژیم ‌غذایی و داروها در درمان و کنترل قند و متابولیسم چربی‌های خون بیماران به‌تنهایی کافی نیستند بلکه انجام فعالیت‌های بدنی و ورزشی نیز باید به برنامه روزانه اضافه شود. .
مواد و روش­ها: پژوهش حاضر از نوع نیمه‌تجربی با طرح پیش‌آزمون و پس‌آزمون می‌باشد. 40 نفر از زنان دارای اضافه‌وزن به‌صورت تصادفی در چهار گروه تمرین ترکیبی، تمرین ترکیبی- مکمل، مکمل و کنترل قرار گرفتند. تمرین هوازی به مدت 8 هفته و سه جلسه در هفته  با 75-50 درصد ضربان قلب بیشینه و تمرین TRX در دامنه درک فشار 12 تا 17 در مقیاس بورگ انجام شد. 24 ساعت قبل از شروع تمرین و 48 ساعت پس از اتمام آخرین جلسه، خون‌گیری برای اندازه‌گیری لپتین و ویسفاتین انجام شد. از آزمون تحلیل کوواریانس(Ancova) برای تغییرات بین گروهی و آزمون T همبسته زوجی به‌منظور مقایسه درون‌گروهی استفاده شد. تحلیل داده‌ها توسط نرم‌افزار SPSSversion25 درسطح معناداری P<0.05 صورت گرفت.
نتیجه‌گیری: با توجه به نتایج تحقیق حاضر و از آن‌جایی که تمرین ترکیبی، تأثیر سودمندی بر لپتین و ویسفاتین نسبت به مکمل داشته است می‌توان توصیه کرد افرادی که دارای اضافه‌وزن هستند برای کاهش وزن از تمرین ترکیبی استفاده کنند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Eight Weeks of Combined Training (Aerobic-TRX) and Cinnamon Supplementation on Serum Levels of Leptin and Visfatin in Inactive Overweight Women

نویسندگان [English]

  • Amir Delshad 1
  • maryam dashti 2

1 Assistant Professor, Sports Science Department, Faculty of Literature and Humanities, Qom University, Qom, Iran

2 PhD student, Department of Sports Sciences, Faculty of Physical Education and Sports Sciences, Mazandaran University, Iran

چکیده [English]

Background and Objective: Obesity and overweight have become a global problem. Obesity is increasing sharply, especially in Iranian women. Experts believe that diet and drugs alone are not enough to treat and control sugar and blood fat metabolism of patients, but physical and sports activities should also be added to the daily schedule.
Materials and Methods: The current research is a semi-experimental type with a pre-test and post-test design. 40 overweight women were randomly assigned to four groups of combined exercise, combined exercise-supplement , supplement and control. Aerobic training was performed for 8 weeks and three sessions per week with 50-75% of the maximum heart rate and TRX training in the range of 12 to 17 pressure perception on the Borg scale. 24 hours before the start of training and 48 hours after the end of the last session, blood was taken to measure leptin and visfatin. Then, analysis of covariance (Ancova) test was used for inter-group changes and paired correlation T-test for intra-group comparison. Data analysis was done by SPSS version 25 software at a significance level of P<0.05.
Results: The results show a significant decrease in leptin (p=0.001) and visfatin (p=0.001) values, and the changes for the exercise and exercise-supplement group were more than the cinnamon supplement group.
Conclusion: According to the results of the current research and since combined exercise has a beneficial effect on leptin and visfatin compared to supplements, it can be recommended that overweight people use combined exercise to lose weight.

کلیدواژه‌ها [English]

  • aerobics
  • TRX
  • cinnamon supplement
  • obesity
  1. Emamdost S, Faramarzi M, Bagheri L, Otadi K, Amiri M, Yazdani T. The effect of combined exercise training on plasma Leptin levels and hormonal factors in overweight men. Yafteh. 2014;16(1):79-90.
  2. Rausch LK, Hofer M, Pramsohler S, Kaser S, Ebenbichler C, Haacke S, Gatterer H, Netzer NC. Adiponectin, leptin and visfatin in hypoxia and its effect for weight loss in obesity. Frontiers in endocrinology. 2018;18(9):615.
  3. Jackson VM, Breen DM, Fortin JP, Liou A, Kuzmiski JB, Loomis AK, Rives ML, Shah B, Carpino PA. Latest approaches for the treatment of obesity. Expert opinion on drug discovery. 2015;10(8):825-39.
  4. Khanna D, Khanna S, Khanna P, Kahar P, Patel BM. Obesity: a chronic low-grade inflammation and its markers. Cureus. 2022;14(2).
  5. Moayeri P, Kojouri G, Jafari A, Ahadi AM. Study of selenium nanoparticles and sodium selenite supplementation effects on expression of leptin gene in pregnant ewes placenta. Journal of Veterinary Research. 2019;73(4).
  6. Monteiro L, Pereira JA, Palhinha L, Moraes-Vieira PM. Leptin in the regulation of the immunometabolism of adipose tissue-macrophages. Journal of leukocyte biology. 2019;106(3):703-16.
  7. Maleki S, Behpour N, Tadibi V. The effect of supplementing resistance training with cinnamon on leptin levels in overweight women. The second national conference of sports and health science achievements of Jundi Shapur University of Ahvaz. 2017.
  8. Senkus KE, Crowe-White KM, Bolland AC, Locher JL, Ard JD. Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention. Nutrition & Diabetes. 2022;12(1):30. doi.org/10.1038/s41387-022-00207-1
  9. Rajput PK, Sharma JR, Yadav UC. Cellular and molecular insights into the roles of visfatin in breast cancer cells plasticity programs. Life Sciences. 2022;304:120706. doi.org/10.1016/j.lfs.2022.120706
  10. Mir MM, Mir R, Alghamdi MA, Wani JI, Sabah ZU, Jeelani M, Marakala V, Sohail SK, O’haj M, Alharthi MH, Alamri MM.. Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study. Journal of Personalized Medicine. 2022; 12(5): 735. doi.org/10.3390/jpm12050735
  11. Taşdemir E, Şermet A. The Relationship Between Plasma Adipsin, Adiponectin, Vaspin, Visfatin, and Leptin Levels with Glucose Metabolism and Diabetes Parameters. Haydarpasa Numune Medical Journal. 2019;59(2):95–103
  12. Jiang YK, Deng HY, Qiao ZY, Gong FX. Visfatin level and gestational diabetes mellitus: a systematic review and meta-analysis. Journal of Metabolic Diseases. 2021; 127(5):468-478.  org/10.1080/13813455.2021.1874997
  13. Yin C, Hu W, Wang M, Xiao Y.The role of the adipocytokines vaspin and visfatin in vascular endothelial function and insulin resistance in obese children. BMC Endocrine Disorders. 2019; 19(1):1-8. doi.org/10.1186/s12902-019-0452-6
  14. Harry K, LydiaL y. Immune Control of Adipose Tissue Homeostasis. Trends in Immunology. 2019;40( 9): 857-872. doi.org/10.1016/j.it.2019.07.006
  15. Bagheri R, Rashidlamir A, Ashtary-Larky D, Wong A, Grubbs B, Motevalli MS, Baker JS, Laher I, Zouhal H. Effects of green tea extract supplementation and endurance training on irisin, pro-inflammatory cytokines, and adiponectin concentrations in overweight middle-aged men. European journal of applied physiology. 2020;120:915-23.
  16. Osali A. Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome. Diabetology & Metabolic Syndrome. 2020;12:1-7.
  17. Moosavi R, Nazarali P, Kazemi F. Effects of eight weeks of TRX training on serum levels of PGC-1α and citrate synthase in overweight women. Tehran University Medical Journal TUMS Publications. 2020;77(11):707-14.
  18. Shaaban Poursouri Hamed. Comparison of the effects of combined TRX and HIIT exercises on changes in growth hormone, testosterone, body circumference and fat percentage on young Taekwondo athletes [Master's Thesis]. North University. 2016
  19. Senevirathne BS, Jayasinghe MA, Pavalakumar D, Siriwardhana CG. Ceylon cinnamon: a versatile ingredient for futuristic diabetes management. Journal of future foods. 2022;2(2):125-42.
  20. Arbabi Z, Brarpour I, Ramin M. The effect of six weeks of intense interval training and cinnamon supplement on serum concentration of apelin and insulin resistance in overweight girls. Intern Med Today. 2018;19(14):80-95.
  21. Tofighi, A, & Ghafari, Y. Afsar beygi N, Effect of aerobic training with controlled diet on weight loss in obese men. Nutrition sciences and food. 2012;9(2):85-94.
  22. Vakili J, Amirsasan R, Nourmohammadi O. The effect of four weeks HIIT training with ginseng supplementation on aerobic, anaerobic powers and body composition of Overweight and obese females. Journal of Sport and Exercise Physiology. 2019;12(2):45-54.
  23. Moradi M. The effect of 8 weeks of combined exercise combined with cinnamon supplementation on the hematological level of addicted women, Master's Thesis, Sports Physiology, University of Sistan and Baluchestan. 2015
  24. Roozegar N, Daneshjoo A, Divkan B. Effect of eight weeks of TRX training on balance, fatigue, muscle strength, and speed in women with multiple sclerosis. The Scientific Journal of Rehabilitation Medicine. 2020;9(1):63-73.
  25. Hassanvand H. Comparison of TRX and traditional resistance exercises on some indicators of body composition and balance of inactive men, vol. JSMJ. 2016;1:621-30..
  26. Arab Momeni, Haji Heydari Mahdi. Comparison of the effect of three supplemental methods of cinnamon, aerobic exercise and the combination of these two (exercise-supplement) berglucose, fasting blood insulin and insulin resistance in type 2 diabetic men, Journal of the School of Medicine, Mashhad University of Medical Sciences. 2018; 2(2): 1430-1438.
  27. Rostami F, Shabani R. The effect of eight weeks aerobic training on serum irisin, glucose homeostasis and blood lipid levels in untrained women. Journal of Sabzevar University of Medical Sciences. 2019;26(2):185-93..
  28. Jahandideh A, Rouhani H, Rajabi H, Shariatzadeh M. The effect of eight weeks of combined exercise training on plasma leptin and adiponectin levels in obese boys. Applied health studies in exercise physiology.1400;8(2):33-25
  29. Peng J, Yin L, Wang X. Central and Peripheral Leptin Resistance in Obesity and Improvements of Exercise. Hormones Behav. 2021;133:105006. doi:10.1016/j.yhbeh .2021.105006
  30. Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, et al. Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial. Journal of Clinical Oncology. 2018;36(9):875. doi: 10.1200/JCO.2017.75.7526
  31. Yu N, Ruan Y, Gao X. Systematic review and meta-analysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals. Hormone and Metabolic Research. 2017;49:164–173.
  32. Anche P, Maiya AG, Kamath SU . Lifestyle modification with physical activity promotion on leptin resistance and quality of life in metabolic syndrome – a systematicreview with meta-analysis. Curr Diabetes. 2020;17(3):345-355. doi.org/10.2174/1573399816666200211102917
  33. Mohammadshahi F, Abiri B, Zarei M, Fathi M. Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study. Avicenna Journal Phytomed. 2020;10(3): 243–252.
  34. Shang C, Lin H, Fang X, Wang Y, Jiang Z, Qu Y, Xiang M, Shen Z, Xin L, Lu Y, Gao J. Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes. Food Funct. 2021;12:12194-12220. DOI: 10.1039/D1FO01935J
  35. KhajehLandi M, Bolboli L, Bolbol S, Zabihi B. Effect of One Course Pilates Exercise Program on Serum Levels of Resisti Visfatin, and Chemerin in Overweight Women, the horizon of medical scienes. 2020; 27(1): 39-113
  36. Bekzadeh M, Safi Khani The effect of aerobic exercise with cinnamon consumption on insulin resistance index and plasma levels of blood glucose, visfatin and adiponectin in overweight men with type 2 diabetes; Journal of Applied Sports Physiology. 2017;4(28):177-168.
  37. Zheng LY, Xu X, Wan RH, Xia S, Huang Q. Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes. Diabetology & Metabolic. 2019;11(1):1-7. doi.org/10.1186/s13098-019-0455-5
  38. Berndt J, Kloting N, Kralisch S. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes. 2019; 54(10):2911-6.
  39. Hejazi K, Attarzadeh Hosseini SR, Fathie M, Mosaferi Ziaaldini M, Zaeemi M. The response of irisin serum levels to eight weeks aerobic training with moderate intensity in obese male Wistar rats. Daneshvar Medicine: Basic and Clinical Research Journal. 2018;25(6):49-56.
  40. Reinehr T. Inflammatory markers in children and adolescents with type 2 diabetes mellitus. Clinica Chimica Acta. 2019; 496:100-107. doi.org/10.1016/j.cca.2019.07.006
  41. Lee J, Effects of exercise type and intensity on visfatin and metabolic syndrome in obesity. Revista Brasileira de Medicina do Esporte. 2021;27:170-3. doi.org/10.1590/1517-8692202127022020_0088
  42. Baigzadeh M, Delavar  SH,  Safikhani H. The Effect of Training (Aerobic and Concurrent) and Cinnamon Supplementation on the Plasma Levels of Visfatin and Adiponectin in Overweight Diabetic Men. Journal of Clinical Research in Paramedical Sciences.  2020;9(2): e90906.  doi: 10.5812/jcrps.90906
  43. Cheng C, Li Z, Zhao X, Liao C, Quan J, Bode AM, Cao Y, Luo X. Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases. European Journal of Pharmacology. 2020; 870: 172922. doi.org/10.1016/j.ejphar.2020.172922