Health Education
parisa Mehrdadian; Salime Golabgirnik; Razieh Khosrorad
Abstract
Introduction: Diabetes is a common disease that leaves serious complications. Educating the patient about the disease and self-care methods can prevent negative consequences, but few patients participate in self-care education. The present study explains the understanding and beliefs of diabetic women ...
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Introduction: Diabetes is a common disease that leaves serious complications. Educating the patient about the disease and self-care methods can prevent negative consequences, but few patients participate in self-care education. The present study explains the understanding and beliefs of diabetic women about the barriers to participating in self-care empowerment programs.Materials and Methods: This qualitative research was conducted in Sabzevar city. Purposive sampling was used to select the participants and theoretical sampling was also used to complete the classes. Data was collected by semi-structured interview. A total of 21 diabetic women were interviewed for 6 months. The interviews were analyzed with Graham and Landman 's content analysis method. To ensure consistency and accuracy of data, credibility, transferability, dependability,and conformability criteria were assessed. Results: The results of the qualitative content analysis led to the extraction of 4 main categories including "scientific information related to the disease and self-care", "the way the doctor deals with the patient and the disease", "the physical and mental health status of the patient" and "beliefs and opinions".Conclusion: According to the findings of the research, it is recommended to design interventions for physicians in order to establish more interaction between physicians and patients, considering the influence of their recommendations and behaviors on patients' decision to participate in self-care and attend educational programs
Javad Maleki; Mitra Kheyrabadi; Safiyeh Sophiyan; Reyhaneh Sabbaghzadeh
Volume 21, Issue 4 , September and October 2014, , Pages 637-645
Abstract
Background: Virus htlv-1 is in the retrovirus family; the virus causing human diseases such as adult T-Cell Leukemia (ATL), HAM / TSP and etc… One of the major proteins in the virus is protease that is essential for virus maturation. Inhibitors that ever made for the protease didn’t show any properly ...
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Background: Virus htlv-1 is in the retrovirus family; the virus causing human diseases such as adult T-Cell Leukemia (ATL), HAM / TSP and etc… One of the major proteins in the virus is protease that is essential for virus maturation. Inhibitors that ever made for the protease didn’t show any properly activity. We have created a new series of inhibitors and with using of computational tools to calculate the way of interactions to the protease protein.
Materials and Methods: The compounds based on the similarity of the original peptide and based on peptidomemiticswere created. Compounds were created by software Hyperchem and optimization act on designed ligand and ligand with the protein crystal structure were performed after separating them. ADME and toxicity characteristics of the compounds were obtained by using Web applications in http://lazar-services.in-silico.ch and http://www.molinspiration.com and docking were performed on them.
Results: The results of studies on ADME designed compounds already showed a good result. Toxicity studies also indicate relatively good results; also the docking results were showed good specificity.
Conclusion: Our studies showed that designed inhibitors can be effective drug-like compounds to inhibiting the protein and therefore use to contrast with this virus.