immunology & Biochemistry
Mohammad Shafi Mojadadi; Maryam Amirpour; Mohammad Sahebkar; Maryam Karrabi; saeideh sadat shobeiri
Abstract
Background: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin ...
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Background: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin and psoriasis. In recent years, conflicting results have been obtained, all of which emphasize the importance of investigating this issue. This study aimed to investigate the relationship between serum 25-hydroxy-vitamin D levels and psoriasis.Methods: We conducted a case-control study with psoriasis patients from Vasei Hospital's dermatology clinic and healthy people from Sabzevar Blood Transfusion Center in Iran. Patients with chronic psoriasis (more than 6 months) aged 18 to 65 years were included in the study regardless of the type of psoriasis. This study had a sample size of 177 people (88 cases, and 89 controls). The data collection methods were a questionnaire and blood samples. In both groups, the amount of 25-hydroxy-vitamin D was measured by ELISA method.Results: This study recruited 177 individuals: 78 (44.10%) males and 99 (55.90%) females. The mean age in the case group was 36.95±13.30 and in the control group was 21.34±12.60 years. The mean vitamin D levels had not significant difference between case (19.68±13.60) and control groups (21.34±12.60) (P>0.05).Conclusion: The findings of this study showed that there was no significant difference in vitamin D levels between the case group and the control group, which did not support the hypothesis that vitamin D deficiency is associated with psoriasis.
Mohammad Reza Noori-Daloii; Zahra Sadr
Volume 26, Issue 1 , March and April 2019, , Pages 1-11
Abstract
Background & Objectives Cancer treatment is still one of the main challenges in the field of basic science and clinical science in medicine. Surgery is often the first option in the treatment of cancer, providing the tumor in a way that can be removed. Chemotherapy, radiation therapy, or a combination ...
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Background & Objectives Cancer treatment is still one of the main challenges in the field of basic science and clinical science in medicine. Surgery is often the first option in the treatment of cancer, providing the tumor in a way that can be removed. Chemotherapy, radiation therapy, or a combination of both can be used to reduce the tumor in the pre- or post-surgical stage. Hormone therapy, stem cell and bone marrow cell transplantation, and immunotherapy are among other therapeutic approaches. Immunotherapy or the use of the immune system for treatment, after chemotherapy and radiation therapy is one of the most important complementary and effective methods for treating cancer. Immunotherapy such as chemotherapy is systematically done and used to prevent the spread of malignancies, but unlike that only attacks malignant cells and does not effect on normal cells. Cancer, immune therapy with the direct use of immune system components and makes an active immune response such as stimulating the patient's immune system cells and reintroducing these cells to the individual. Indirect stimulation and the use of immune products such as anti-cancer monoclonal antibody to remove tumor antigens is called passive immune therapy. Results The results from clinical trials confirm the design of combined therapies for cancer treatment, which include a combination of various immune therapies along with chemotherapy or the combination of several therapeutic immunotherapy approaches. Conclusion The goal of this review article is to concisely review some of the most important recent developments in cancer immunology and immunotherapy, and explain new insights into the mechanisms that underlie cancer immune evasion by which might lead to pathways for identifying novel treatments.
Batol Haj Ebrahimi; Mohammad Kazemi Arab Abadi
Volume 20, Issue 3 , September and October 2013, , Pages 380-389
Abstract
Depression is a main complication in the developed and in developing countries. Studies showed that depression not only is a emotional disease but also affect the body. Immune system disordering is an important complication following depression. Studies showed that depression can induce immunological ...
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Depression is a main complication in the developed and in developing countries. Studies showed that depression not only is a emotional disease but also affect the body. Immune system disordering is an important complication following depression. Studies showed that depression can induce immunological chronic inflammation, hence, lead to accelerate depression. Several molecules including JAK/STAT pathways and Toll like receptors, AIMII and NLRs play important roles in inducing chronic inflammation. It seems that the mentioned molecules can induce inflammation via cytokine production in depressed patients. Therefore, evaluation of cytokine patterns and cytokines producing pathways in depressed patients can help scientists to find the pathogenesis of depression. Thus, the aim of this review article was to collect recent information regarding cytokine patterns as well as the related molecules in inflammation in depression.
MR HAMEDI NIA; AH HAGHIGHI; P JAMILI
Volume 13, Issue 4 , January and February 2007, , Pages 204-210
Abstract
Background and purpose: C-reactive protein is a sensitive, nonspecific marker of inflammation and its relationship with coronary vascular disease is already established. The present research was conducted to study the effect of resistance training on the rate of C-reactive protein in obese men.
Methods ...
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Background and purpose: C-reactive protein is a sensitive, nonspecific marker of inflammation and its relationship with coronary vascular disease is already established. The present research was conducted to study the effect of resistance training on the rate of C-reactive protein in obese men.
Methods and Materials: The present study was quasi-experimental and 24 male subjects (16 obese, 8 lean) with age range of 35 to 48 years voluntarily participated in the study. Obese men were randomly assigned into two groups: resistance training and control group. The third group included the lean men subjects. Fasting blood samples were taken from all subjects. The experimental subjects received resistance training for 13 weeks, 3 sessions per week. The resistance training was done in circuit fashion in 11 stations with a 50 to 60% intensity of one maximum repetition (IRM).
Results: Resistance training significantly decreased the serum CRP levels of the obese men (from 1.65±0.6 to 0.53±0.73). In addition, serum CRP concentrations in obese men at baseline state were significantly higher than those in lean men (1.56±0.58 versus 0.26±0.21). In all subjects there was a significant and positive correlation between serum CRP levels and obesity markers (r=0.75) and different components of the metabolic syndrome.
Conclusion: Resistance training due to antinflammatory effects is likely to reduce the risk of future cardiovascular events in obese men.