نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار، گروه میکروبیولوژی و ایمونولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
2 کارشناس ارشد، گروه گفتاردرمانی، مرکز تحقیقات سلامت سالمندان، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
3 کارشناس، گروه میکروبیولوژی، آزمایشگاه میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
4 دانشیار، گروه علوم تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
چکیده
اهداف توکسوپلاسما گوندی انگلی پروتوزئری داخل سلولی اجباری است که همه موجودات خون‌گرم ازجمله انسان را مبتلا می‌کند. عفونت حاد توکسوپلاسما در زنان باردار اغلب منجربه توکسوپلاسموزیس مادرزادی می‌شود که ممکن است باعث سقط جنین یا عوارض دیگری همچون تولد زودرس، عوارض نورولوژیکی دائمی و آسیب‌های بینایی شود. هدف از این تحقیق تعیین وضعیت آنتیبادیهای ضدتوکسوپلاسموزیس در دانشجویان دختر دانشگاه علوم پزشکی سبزوار است.
مواد و روش ها در این مطالعه مقطعی 137 نمونه خون از 137 دانشجوی دختر به‌صورت اتفاقی گرفته و برای اندازه‌گیری میزان آنتیبادیهای ضدتوکسوپلاسموزیس با روش الایزا استفاده شد. در این پژوهش پرسش‌نامه‌ای تنظیم شد و در اختیار این افراد قرار داده شد و اطلاعاتی ازقبیل سابقه مصرف گوشت به‌صورت کباب و نیم‌پز، سابقه تماس با گربه و محل سکونت جمع‌آوری شد. همچنین تحلیل یافته‌ها با نرم‌افزار SPSS و آزمون مجذور کای صورت گرفت.
یافته ها آنتیبادیهای IgG ضدتوکسوپلاسما در 18 نمونه (1/13درصد) به مقدار قابل‌توجه وجود داشت (مثبت بود). همه نمونه‌ها از نظر آنتی‌بادی IgM منفی بودند. ارتباط آماری معناداری بین موارد مثبت IgG و عواملی همچون محل سکونت، مصرف کباب، مصرف سبزیجات خام و تماس با گربه به‌دست نیامد (1/0P>).
نتیجه گیری نتایج این مطالعه نشان داد که 9/86درصد دانشجویان دختر نسبت‌به آنتیبادیهای ضدتوکسوپلاسما سرونگاتیو بوده و نسبت‌به این عفونت درمعرض خطر هستند و باید درباره پیشگیری از بیماری توکسوپلاسموزیس مادرزادی در زمان بارداری آموزش داده شوند.
کلیدواژه‌ها
عنوان مقاله [English]
A Seroepidemiological Study of Toxoplasmosis Among Female Students of Sabzevar University of Medical Sciences
نویسندگان [English]
- Mohammad-Shafi Mojadadi 1
- Najmeh Mahmoodabadi 2
- Zohreh Sajadiniya 3
- Rahim Golmohamadi 4
- Hossein Elyasi 1
1 Assistant Professor, Department of Microbiology and Immunology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
2 MSc., Department of Speech Therapy, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 BSc., Department of Microbiology, Laboratory of Microbiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
4 Associate Professor, Department of Anatomy, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
چکیده [English]
Background Toxoplasma gondii is an obligate intracellular protozoan parasite that infects all warm-blooded animals, including humans. Acute infection with Toxoplasma gondii in pregnant women frequently leads to congenital toxoplasmosis which may cause abortion or severe diseases such as premature birth, permanent neurological damage, and visual impairment in the baby. Serological survey in females before marriage can reveal immune status of them against toxoplasmosis. This research aimed to determine the anti-toxoplasma antibodies in female students of Sabzevar University of Medical Sciences, Sabzevar, Iran.
Materials & Methods In this cross-sectional study, 137 blood samples were taken from female students that were randomly selected and used for the measurement of anti-toxoplasma antibodies by ELISA method. Using a researcher-designed questionnaire, information such as consuming grilled and undercooked meat, exposure to cats and residency status was collected. The data analysis was performed by Chi-square test using SPSS.
Results The detected IgG antibodies in 18(13.1%) samples were significant, and no IgM antibody was found in the studied samples. There were no significant differences between infection and factors such as residency status (urban/rural), vegetables consumption, cat keeping, eating underdone and roasted meat (P>0.1).
Conclusion The results of this study revealed that 86.9% of female students were seronegative and at high risk for acquiring infection, thus they should be educated to prevent contracting congenital toxoplasmosis during the period of pregnancy.
کلیدواژه‌ها [English]
- Seroepidemiology
- Toxoplasmosis
- Female student
- sabzevar
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