نوع مقاله : مقاله پژوهشی
نویسندگان
استادیار، گروه زیست‌شناسی، دانشگاه پیام نور، تهران، ایران
چکیده
زمینه و هدف: سبک نادرست تغذیه، از عوامل ابتلا به افزایش کلسترول و چربی خون است و در صورت رسیدگی نکردن، به دلیل التهاب بالای سلول‌های کبدی منجر به بروز کبد چرب می‌گردد. هدف از این مطالعه، بررسی تأثیر آنتی هایپرلیپیدمی دمنوش Rosa damascena Mill و Cassia angustifolia Vahl بر پروفایل چربی رت‌های نر می‌باشد.
مواد و روش‌ها: در این مطالعه تجربی، 28 رأس رت نر (20± 220 گرمی) به‌طور تصادفی به چهار گروه (n=7) کنترل، شاهد تغذیه‌شده با رژیم پرچرب، تجربی تغذیه‌شده با رژیم پرچرب + دمنوش، تجربی تغذیه‌شده با رژیم عادی + دمنوش، تقسیم شدند. گروه‌های تحت تیمار با دمنوش طی سه دوره با فاصله دو روز در میان دمنوش برگ سنای مکی (0.4 گرم / کیلوگرم) به اضافه گل سرخ (0.2 گرم / کیلوگرم) را دریافت کردند. پس از 28 روز، حیوان بیهوش و پس از خون‌گیری از قلب، فاکتورهای خونی موردنظر سنجیده شدند.
یافته‌ها: براساس نتایج، پروفایل چربی، به‌جز آنزیم AST، به‌طور معنی‌داری (p ≤ 0.05) در گروه تجربی تغذیه‌شده با رژیم پرچرب + دمنوش، کاهش یافته بود. پروفایل چربی در گروه تجربی تغذیه‌شده با رژیم عادی + دمنوش، تفاوت معنی‌داری با گروه کنترل نشان نداد به‌جز آنزیم AST که به‌طور معنی‌داری (p ≤ 0.05) نسبت به گروه کنترل افزایش یافت.
نتیجه‌گیری: دمنوش ترکیبی Rosa damascena Mill و Cassia angustifolia Vahl می‌تواند به‌عنوان دارویی با اثربخشی سریع به‌خصوص در افراد مبتلا به هایپرلیپیدمی مطرح گردد
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
Investigation of the Effect of Herbal Tea of Cassia angustifolia Vahl and Rosa damascena Mill on Lipid Profile in Male Wistar Rats
نویسندگان [English]
- Zolfaghar Lotfi
- Alieh Safamanesh
Assistant Professor, Department of Basic Sciences, Payame Noor University, Tehran, Iran
چکیده [English]
Introduction: Inadequate nutrition is one of the causes of high cholesterol and blood lipid, which if untreated, due to the high inflammation of liver cells, can lead to fatty liver. The aim of this study was to evaluate the anti-hyperlipidemia effect of herbal tea of Rosa damascena Mill and Cassia angustifolia Vahl on lipid profile in male rats.
Materials and Methods: In this experimental study, 28 male rats (220 ± 20 g) were randomly divided into four groups (n = 7 each): control, control + high-fat diet, experimental group + high-fat diet + herbal tea, and experimental group + herbal tea. The groups were treated with herbal tea of Cassia angustifolia Vahl (0.4 g/kg) plus Rosa damascena Mill (0.2 g/kg) in three time periods with two days interval. After 28 days, the animals were anesthetized, and blood samples were collected from the heart. Blood parameters were measured using an autoanalyzer.
Results: Based on the results, lipid profile, except for the AST enzyme, significantly decreased in the experimental group with high-fat diet + herbal tea. In the experimental group with normal diet + herbal tea, the profile did not show any significant difference; however, AST enzyme increased significantly (p ≤ 0.05), as compared to the control group.
Conclusion: Herbal tea prepared with a combination of Cassia angustifolia Vahl and Rosa damascena Mill can be considered as a drug with rapid efficacy in people with hyperlipidemia.
کلیدواژه‌ها [English]
- Cassia angustifolia Vahl
- Hyperlipidemia, Liver enzymes
- Rosa damascena Mill
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