بررسی تغییرات آمینوترانسفرازهای کبدی و مقاومت به انسولین پس از 4 هفته تمرینات تناوبی شدید و مصرف مکمل زنجبیل در مردان میان‌سال فعال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه سیستان و بلوچستان، زاهدان

2 دکتری فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه زابل، زابل

چکیده

زمینه و هدف: سنجش آمینوترانسفرازهای کبدی و مقاومت به انسولین، به دنبال فعالیت ورزشی به‌منظور پیشگیری از بیماری کبدی، همواره اهمیت بالایی داشته است. هدف از انجام این پژوهش، تعیین تأثیر 4 هفته تمرین تناوبی شدید همراه با مصرف زنجبیل بر سطوح سرمی آنزیم‌های کبدی و مقاومت به انسولین پیشکسوتان فوتبال بود.
مواد و روش‌ها: در این مطالعه نیمه‌تجربی،46 مرد پیشکسوت فوتبالیست (50-40 سال) به روش نمونه‌گیری انتخابی در دسترس و هدف‌دار، انتخاب شدند و به‌صورت تصادفی در چهار گروه زنجبیل، تمرین- دارونما، تمرین- زنجبیل و کنترل تقسیم شدند. گروه‌های تمرینی به مدت 4 هفته به اجرای تمرینات تناوبی شدید با شدت90 درصد ضربان قلب بیشینه پرداختند؛ در حالی که گروه‌های مکمل، روزانه سه عددکپسول 1000میلی‌گرمی زنجبیل مصرف کردند. خون‌گیری از افراد موردمطالعه، قبل و 48 ساعت پس از مداخله در حالت ناشتایی انجام شد. داده‌ها با آزمون‌های آماری شاپیروویلک، آنالیزواریانس دوراهه و تست تعقیبی توکی در سطح معناداری 0/05≤ p تجزیه‌وتحلیل شدند.
یافته‌ها: 4 هفته تمرین و مصرف مکمل موجب کاهش معنادار سطوح HOMA، ALT، AST، گلوکز، انسولین، وزن، WC و BMI در سه گروه دارای مداخله (زنجبیل، تمرین-دارونما و تمرین-زنجبیل) نسبت به پیش‌آزمون گردید (05/0 p≤). میانگین تغییرات این شاخص‌ها در گروه تمرین- زنجبیل به‌طور معناداری کاهش بیشتری از سایر گروه‌ها نشان داد (0/05≤p)..
نتیجه‌گیری: به نظر می‌رسد مصرف زنجبیل همراه با تمرین تناوبی شدید با افزایش سوخت‌وساز چربی‌ها از طریق تأثیر مطلوب بر سطوح آنزیم‌های کبدی و مقاومت به انسولین و ترکیبات بدن، عامل کارآمدی در پیشگیری و بهبود کبد چرب غیرالکلی در مردان پیشکسوت فوتبال است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The Assessment of Changes in Liver Aminotransferases and Insulin Resistance Following 4 Weeks of High Intensity Interval Training and Ginger Supplementation in Active Middle Aged Men

نویسندگان [English]

  • shila Nayebi far 1
  • Elham Ghasemi 2
1 Assistant professor in exercise physiology, Department of Sport Sciences, Faculty of Educational Sciences and Psychology, University of Sistan and Baluchestan, Zahedan
2 Phd in exercise physiology, Department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol
چکیده [English]

Introduction: The assessment of changes in liver Aminotranspherases and Insulin resistance following 4 weeks of exercise trainings have been of great importance in order to prevent liver diseases. The purpose of present study is to determine the effect of 4 weeks of high intensity interval trainings together with ginger on serum levels of liver enzymes and insulin resistance in pioneer football players. Materials and Methods: In this semi-experimental study, 46 football pioneer men (40-50 years) were selected according to selective and on purpose sampling, and were divided into 4 groups of Ginger+Training, Gnger, Training+placebo and control. The training groups performed high intensity trainings for 4 weeks with 90% HRmax while supplementation groups consumed 3×1000 mg ginger capsules daily. Blood sampling was done before and 48 hours after the intervention in fasting state. Data were analyzed using Shapiro-wilk, Two way ANOVA and Tukey post hoc tests in p < 0.05 significant level. Results: 4 weeks of ginger and HIIT decreased HOMA, ALT, AST, Glucose, Insulin, weight, WC and BMI significantly in experimental groups (Ginger, Train-Ginger, Train-placebo) compared to pretest (p≤0.05). The mean changes in mentioned indices showed better improvements in ginger+training group compared to other groups (p≤0.05). Conclusion: It seems that ginger intake together with high intensity interval exercises is an efficient factor in non-alcoholic fatty liver prevention and improvement by augmentation in fat metabolism through putting desirable results on serum liver enzymes, insulin resistance and body composition in pioneer football men players. 

کلیدواژه‌ها [English]

  • HIIT
  • ginger
  • liver enzymes
  • insulin resistance
[1]. Moradi B, Azarbayjani MA, Peeri M. Effect of Curcumin Supplementation and Resistance Training in Patients with Nonalcoholic Fatty Liver Disease. Journal of Medicinal Plants. [Research]. 2016;4(60):161-72.
[2]. Rinella ME. "Nonalcoholic fatty liver disease: asystematic review". JAMA (Systematic review)2015; 313: 2263–73.
[3]. Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annual review of nutrition, 2010, 30:273-290.
[4]. Nobili V, Carter-Kent C, Feldstein AE. The role of lifestyle changes in the management of chronic liver disease. BMC medicine, 2011, 9:70.
[5]. Whitsett M, VanWagner LB. Physical activity as a treatment of non-alcoholic fatty liver disease: a systematic review. World J Hepatol 2015; 7(16): 2041–2052.
[6]. Zhang HJ, He J, Pan LL, Ma ZM, Han CK, Chen CS, et al. Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: a randomized clinical trial. JAMA Intern Med 2016; 176(8):1074–1082.
[7]. Marcinko K, Sikkema SR, Samaan MC, Kemp BE, Fullerton MD, Steinberg GR. High-intensity interval training improves liver and adipose tissue insulin sensitivity. MolMetab 2015; 4(12): 903-915.
[8]. Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, et al. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. ClinSci (Lond) 2015; 129(12):1097-1105.
[9]. Mirghani SJ,Yousefi MS. The effect of interval recovery periods during HIIT on liver enzymes and lipid profile in overweight women. Sci& Sports 2015; 30 (3): 147-154.
[10]. Ziegler S, Schaller G, Mittermayer F. Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease. Arch Phys Med Rehabil, 2006; 87: 265-269.
[11]. Rahimlu M, Yari Z, Hekmat f, Seyyed M, Farmer SA, et al. The Effect of Ginger Supplement on Liver Enzymes and Steatosis and Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver. J Nutrition Sci Food Technol Iran 2016; (2):8- 1. [in Persian]
[12]. Fathei M, Kheirabadi S, Ramezani F, Hejazi K. The effects of eight weeks aerobic training, green tea supplementation and compound of them on serum liver enzymes and apolipoproteins in inactive overweight women. Medical Journal of Mashhad University of Medical Sciences, 2016:59(2):114-123. [13]. Fathei M, Kheirabadi S, Hejazi K. Changes in insulin resistance markers and some liver enzymes and cardiovascular risk factors to aerobic training and green tea supplement consumption. Complementary Medicine Journal of faculty of Nursing & Midwifery, 2017: 6 (4):17031716.
[14]. Mir E, Attarzadeh Hosseini SR, Hejazi K, Mir Sayeedi M. Effect of eight weeks of endurance andresistance training on serum adiponectin and Insulin resistance index of inactive elderly men. J Gorgan Univ Med Sci. 2016; 18 (1) :69-77. URL: http://goums.ac.ir/journal/article-1-2659fa.html.
[15]. Azamian Jazi A, Gharekhani M. The Effect of Aerobic Exercise Training on Serum Resistin Levels and its Relation to Insulin Resistance in Overweight Older Women. Journal of Applied Exercise Physiology,2014; 8 (15):41-52.
[16]. Nayebifar S, Afzalpour M E, Kazemi T, AbtahiEivary S H, Mogharnasi M. Changes in Blood Pressure, Body Composition, and Vo2max after 10 Weeks of High Intense Interval Training and Ginger Consumption in Overweight Women. Qom Univ Med Sci J, 2017;11(6):19-27 URL: http://journal.muq.ac.ir/article-1-824-fa.html.
[17]. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, Hawk VH, Muehlbauer MJ, Samsa GP, Nelson RC, et al. 2011. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American journal of physiology. 2011;301(5):1033-1039.
[18]. Sakr SA, Mahran HA, Lamfon HA. Protective effect of ginger (Zingiberofficinale) on adriamycininducedhepatotoxicity in albino rats. J Med Plant Res 2011; 5:133-40.
[19]. Winn NC, Liu Y, Rector RS, Parks EJ, Ibdah JA, Kanaley JA. Energy-matched moderate and high-intensity exercise training improves nonalcoholic fatty liver disease risk independent of changes in body mass or abdominal adiposity - A randomized trial. Metabolism 2018; 78:128140.
[20]. van der Heijden GJ, Wang ZJ, Chu ZD, Sauer PJ, Haymond MW, et al. A 12‐week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, hispanic adolescents. Obesity 2010; 18:384-90.
[21]. Kazemi A, Rahmati M, Dabaghzadeh R, Raisi S, Molaie S. The effect ofhigh volume high intensity interval trainingon serum visfatin and vaspin, insulin resistance, lipid profile and body composition of overweight men. JournalofShahed University 2015, 22 (114): 55-61.
[22]. EsmaelzadehToloee M, Faramarz M, NoroozianGhahfarokhi P. Effect of Aerobic Training with Ginger Supplementation on some Liver Enzymes(AST,ALT,GGT) and Resistance to Insulin in Obese Women with Type 2 Diabetes. Medical Journal of Mashhad 2017, 60. 4: 636-647.
[23]. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S, et al. The effect of ginger (Zingiberofficinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med 2015; 12(2): 165-70.
[24]. Noushabadi A, Abedi B. Effects of combination training on insulin resistance index and some inflammatory markers in inactive men. Horizon Med Sci 2012;18(3):95-105.
[25]. Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. ApplPhysiolNutrMetab 2009; 34:396-402.
[26]. Marchesini G, Petta S, Dalle Grave R. Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice. Hepatology 2016; 63(6): 2032-2043.
[27]. George AS, Bauman A, Johnston A, Farrell G, Chey T, George J. Effect of alifestyle intervention in patients with abnormal liver enzymes and metabolicrisk factors. J GastroenterolHepatol 2009; 24: 399–407.
[28]. Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, et al. The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes ObesMetab 2012; 14:139-48
[29]. Magkos F. Exercise and fat accumulation in the human liver. Current opinion in lipidology 2010. 21(6):507-17.
[30]. Li Y1, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of Zingiberofficinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evid Based Complement Alternat Med 2012;5166870.