اثر 8 هفته تمرین هوازی منظم بر سطوح TNF-α و نیم‌رخ لیپیدی دختران چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشیار، گروه تربیت بدنی، واحد قائم‌شهر، دانشگاه آزاد اسلامی واحد قائم‌شهر، قائم‌شهر، ایران

2 کارشناس ارشد، گروه تربیت بدنی، واحد قائم‌شهر، دانشگاه آزاد اسلامی واحد قائم‌شهر، قائم‌شهر، ایران

چکیده

زمینه و هدف  چاقی دوران کودکی با افزایش خطر عوارض بیماری‌های قلبی- عروقی و متابولیکی از جمله هایپرلیپیدیما همراه است و به‌عنوان یک وضعیت التهابی مزمن با درجه کم در نظر گرفته می‌شود؛ از این رو هدف از مطالعه حاضر، بررسی اثر 8 هفته تمرین هوازی منظم بر سطوح فاکتور نکروزدهنده تومور آلفا (TNF-α) و نیم‌رخ لیپیدی دختران چاق بود.
مواد و روش‌ها در این مطالعه نیمه‌تحربی، 14 دختر چاق با میانگین سنی 1/18± 9/9 سال و شاخص توده بدن 95 درصد یا بیشتر، انتخاب و به‌طور تصادفی به گروه‌های تمرین و کنترل تقسیم شدند. تمرین هوازی شامل حرکات ورزشی با شدت 50 تا 70 درصد ضربان قلب حداکثر، 3 جلسه در هفته و به مدت 8 هفته بود. نمونه‌های خونی ناشتا قبل و 48 ساعت پس از آخرین مداخله جمع‌آوری شد. سطوح سرمی TNF-α، تری‌گلیسیرید، کلسترول تام، لیپوپروتئین با چگالی بالا (HDL-C) و لیپوپروتئین با چگالی کم (LDL-C) اندازه‌گیری شد. از آزمون‌های t مستقل و زوجی برای تجزیه و تحلیل داده‌ها استفاده شد (0/05>p).
یافته‌ها 8 هفته تمرین هوازی منجر به کاهش سطوح TNF-α، تری‌گلیسرید، کلسترول تام، LDL-C و افزایش سطوح HDL-C در دختران چاق شد (0/05>p). در مقایسه با گروه کنترل درصد تعییرات متغیرها در گروه تمرین بالاتر بود (0/05>p).
نتیجه‌گیری فعالیت ورزشی هوازی به‌عنوان یک مداخله درمانی غیردارویی برای کودکان چاق می‌تواند منجر به کاهش عوامل خطرزای بیماری‌های قلبی- عروقی و متابولیکی از طریق بهبود نیم‌رخ لیپیدی و کاهش التهاب سیستماتیک شود.
 

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The Effects of 8 weeks of regular aerobic exercise on the TNF-α levels and lipid profile in obese girls

نویسندگان [English]

  • Masoumeh habibian 1
  • Saied Amirnia Shobi 2
  • Emamali Zakeri Khatir 2
1 Associate Professor in Exercise Physiology,Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran
2 Master of Exercise Physiology, Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran
چکیده [English]

Introduction: Childhood obesity is associated with an increased risk for several metabolic and cardiovascular complications, and is now considered as a state of chronic low-grade inflammation. The aim of this study was to invistigate of the effect 8 weeks of regular aerobic exercise on the Tumor necrosis factor alpha (TNF-α) and lipid profile in obese girls.
Materials and Methods: This semi experimental research, 14 obese girls (mean age 9.9±1.18 year) whose body mass index was 95% or greater were selected and assigned randomly to two equal groups as follow: exercise and control groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions/week for 8 weeks. Fasting blood samples were collected before and 48 hour after the last intervention. The serum levels of TNF-α, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDL-C) were measured. Data were analyzed by paired and independent t tests. The level of statistical significance was set at p < 0.05.
Results: Eight weeks of aerobic exercise caused a significant decrease in TNF-α, triglycerides, total cholesterol, LDL-C and an increase in HDL-C levels (p < 0.05). Compared with the control group, the percent changes of these variabls in exercise training group were significantly greater (p < 0.05). Conclusion: Aerobic exercise as a non-medical therapeutic intervention for obese children can leads to reduced cardiovascular and metabolic diseases risk factors by improving lipid profiles and a reducse in systemic inflammation.
Received

کلیدواژه‌ها [English]

  • Aerobic Exercise
  • CHOLESTEROL
  • Triglycerides
  • Tumor Necrosis Factor-alpha
  • Obesity
[1]. Yao H, Hou C, Liu W, Yi J, Su W, Hou Q. Associations of multiple serum biomarkers and the risk of cardiovascular disease in China. BMC Cardiovasc Disord. 2020;20(1):426.
[2]. Shi C, Zhu L, Chen X, Gu N, Chen L, Zhu L, et al. IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b. J Interferon Cytokine Res. 2014;34(5):342-8.
[3]. McArdle MA, Finucane OM, Connaughton RM, McMorrow AM, Roche HM. Mechanisms of obesityinduced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne). 2013;4:52.
[4]. Kern L, Mittenbühler MJ, Vesting AJ, Ostermann AL, Wunderlich CM, Wunderlich FT. Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers (Basel). 2018;11(1):1-21.
[5]. Gherlan I, Vladoiu S, Alexiu F, Giurcaneanu M, Oros S, Brehar A, et al. Adipocytokine profile and insulin resistance in childhood obesity. Maedica (Buchar). 2012;7(3):205-13.
[6]. Taiebi Khosroshahi H, Talebi Y, Ahmadzadeh S, Habibzadeh A, Mousavi SE, Khalilzadeh M. The Effects of Intravenous Vitamin C Administration on hs-CRP and Tumor Necrosis Factor-α Levels in Haemodialysis Patients. FFHD 2011;1(8):255-261.
[7]. Tzanavari T, Giannogonas P, Karalis KP. TNF-alpha and obesity. Curr Dir Autoimmun. 2010;11:145-56.
[8]. Kojta I, Chacińska M, Błachnio-Zabielska A. Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance. Nutrients. 2020;12(5):1305.
[9]. Faienza MF, D'Amato G, Chiarito M, Colaianni G, Colucci S, Grano M, et al. Mechanisms Involved in Childhood Obesity-Related Bone Fragility. Front Endocrinol (Lausanne). 2019;10:269.
[10]. Klünder-Klünder M, Flores-Huerta S, García-Macedo R, Peralta-Romero J, Cruz M. Adiponectin in eutrophic and obese children as a biomarker to predict metabolic syndrome and each of its components .BMC Public Health 2013;13:1-8.
[11]. Carroll MD, Fryar CD, Kit BK. Total and high-density lipoprotein cholesterol in adults: National Health and Nutrition Examination Survey, 2011-2014. NCHS Data Brief. 2015;(226):1-8.
[12]. Song K, Park G, Choi Y, Oh JS, Choi HS, Suh J, et al. Association of Vitamin D Status and Physical Activity with Lipid Profile in Korean Children and Adolescents: A Population-Based Study. Children (Basel). 2020 19;7(11):241.
[13]. Reddy P, Vishwakarma R, Satyanarayana K. Study of lipid profile in overweight and obese children. IJHCR. 2020;3(5):55-62.
[14]. Huang CJ, McAllister MJ, Slusher1 AL, Webb HE, Mock JT, Acevedo EO. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Med Open. 2015;1(1):32.
[15]. Krüger K, Mooren FC, Eder K, Ringseis R.Immune and Inflammatory Signaling Pathways in Exercise and Obesity. AJLM 2016;10(4): 268-279.
[16]. Baran J, Weres A, Czenczek-Lewandowska E, Wyszyńska J, Łuszczki E, Dereń K, et al. Blood lipid profile and body composition in a pediatric population with different levels of physical activity. Lipids Health Dis. 2018;17(1):171.
[17]. García-Hermoso A, Ramírez-Vélez R, Saavedra JM. Exercise, health outcomes, and pædiatric obesity: A systematic review of meta-analyses. J Sci Med Sport. 2019;22(1):76-84.
[18]. Habibian M, Rezaye Mousavi S. The Effects of Regular Aerobic Exercise on the Serum levels of Plasminogen Activator Inhibitor-1 and Adiponectin in Obese Girls. JQUMS. 2019; 23(5):418-429. (Persian).
[19]. Castillo EC, Elizondo-Montemayor L, Hernández-Brenes C, Rodríguez-Sánchez DG, Silva-Platas C, et al. Integrative Analysis of Lipid Profiles in Plasma Allows Cardiometabolic Risk Factor Clustering in Children with Metabolically Unhealthy Obesity. Oxidative Med. Cell. Longev.2020;2020:1-15.
[20]. Breslin WL, Johnston CA, Strohacker K, Carpenter KC, Davidson TR, Moreno JP, et al.Obese Mexican American children have elevated MCP-1, TNF-α, monocyte concentration, and dyslipidemia. Pediatrics.2012;129(5):e1180-6.
[21]. Kazemi A, Rahmati M, Fariabi M, Taherabadi SJ. High intensity Interval Training (HIT on Body weight and serum levels of TNF-α, insulin and lipid profile in obese children. RJMS. 2016; 22 (139):1-7. (Persian).
[22]. Ramezani A, Akbari M. Effect of High Intensity Training on Serum TNFα in Obese Children. J Rehab Med. 2017;6(2):102-109. (Persian).
[23]. Many G, Hurtado ME, Tanner C, Houmard J, GordishDressman H, Park JJ, et al. Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens. Pediatr Exerc Sci. 2013;25(1):12-26.
[24]. Han Y, Liu Y, Zhao Z, Zhen S, Chen J, Ding N, et al. Does Physical Activity-Based Intervention Improve Systemic Proinflammatory Cytokine Levels in Overweight or Obese Children and Adolescents? Insights from a MetaAnalysis of Randomized Control Trials. Obes Facts. 2019;12(6):653-668.
[25]. Koh Y, Park KS. Responses of inflammatory cytokines following moderate intensity walking exercise in overweight or obese individuals. J Exerc Rehabil. 2017;13(4):472-476.
[26]. Jin CH, Rhyu HS, Kim JY. The effects of combined aerobic and resistance training on inflammatory markers in obese men. J Exerc Rehabil. 2018;14(4):660-665.
[27]. Ramezani AR, Gaeini AA, Hosseini M, Mohammadi J. Effect of Endurance, Strength and Combined Training on Lipid Profile, Insulin Resistance, and Serum Adiponectin Levels in Inactive Obese Children. Armaghane-danesh. 2016;21 (7):641-654. (Persian).
[28]. Jafari A, Ramezani A. The Effect of Eight Weeks of Concurrent Endurance Interval and Resistance Training and Concurrent Endurance Continuous and Resistance Training on Strength, Body Composition and Lipid Profiles in Non-Athlete 14-17-Year-Old Overweight Boys. Journal of sport biosciences 2013;l4(15): 5-22. (Persian).
[29]. Gordon B, Chen S, Durstine JL.The effects of exercise training on the traditional lipid profile and beyond. Curr Sports Med Rep. 2014;13(4):253-9.
[30]. Touati S, Montezano AC, Meziri F, Riva C, Touyz RM, Laurant P. Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase, ERK1/2 and SAPK/JNK down‐regulation in obese rats. Clin Exp Pharmacol Physiol. 2015;42(2):179-85.
[31]. Ellulu MS. Obesity, cardiovascular disease, and role of vitamin C on inflammation: A r eview of facts and underlying mechanisms. Inflammopharmacology 2017;25(3):313-328.
[32]. Habibian, M, Peeri M, Azarbayjani, M, Hedayati M. Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats. JBUMS. 2013;15 (1):30-37. (Persian).