تأثیر تمرین هوازی با شدت بالا و متوسط بر سطوح سرمی فاکتور رشد فیبروبلاستی-21 و فعالیت آنزیم پاراکسوناز-1 در موش‌های صحرایی مبتلا به کبد چرب غیرالکلی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری،گروه فیزیولوژی ورزشی، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

2 دانشیار،گروه فیزیولوژی ورزشی، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

3 استادیار،گروه فیزیولوژی ورزشی، واحد آیت‌الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

4 دانشیار، گروه فیزیولوژی ورزشی، واحد ساری، دانشگاه آزاد اسلامی، ساری، ایران

چکیده

زمینه و هدف کبد چرب غیرالکلی، تجمع چربی در کبد است که خطر بروز بیماری قلبی- عروقی، کارسینومای کبدی و دیابت را افزایش می‌دهد و تمرینات بدنی می‌تواند احتمالاً سبب کاهش چربی کبدی گردد. هدف مطالعه حاضر، بررسی تأثیر هشت هفته تمرین هوازی با شدت بالا و متوسط بر سطوح سرمیFGF-21 و آنزیمPON-1 در کبد چرب غیرالکلی بود.
مواد و روش‌هادر این مطالعه تجربی 40 سر موش صحرایی نر بالغ ویستار (با میانگین وزن 10±210 گرم) به‌طور تصادفی به پنج گروه مساوی 1) کنترل (سالم) 2) کنترل (کبد چرب) 3) سالین 4) تمرین با شدت بالا و 5) تمرین با شدت متوسط تقسیم شدند. دوره تمرین در مدت هشت هفته، پنج جلسه در هفته و هر جلسه 45 دقیقه انجام شد. نمونه‌هایسرمیدر 48 ساعتپسازآخرینجلسهتمرینیودروضعیت 12 ساعتناشتاییجمع‌آوریشد. آنالیزواریانسیک‌طرفهوآزمونتوکیدرسطحP < 0.05مورداستفادهقرارگرفت.
یافته‌هاسطوح سرمی FGF-21 در گروه تمرین با شدت بالا و شدت متوسط در مقایسه با گروه کنترل (کبد چرب) کاهش معناداری داشت (P≤0.001). همچنین سطوح سرمی PON-1 در گروه تمرین با شدت بالا و شدت متوسط در مقایسه با گروه کنترل (کبد چرب) کاهش معناداری داشت (P≤0.01) و تفاوت معناداری بین دو گروه تمرینی مشاهده نشد.
نتیجه‌گیریطبق نتایج این مطالعه، تمرین ورزشی با شدت بالا و متوسط با کاهش FGF-21 و افزایشPON-1 سرمی می‌تواند سبب کاهش خطرات اختلالات کبدی در موش‌های صحرایی مبتلا به کبدچرب غیرالکلی گردد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effect of High and Moderate Aerobic Exercise on Serum Fibroplast-21 Growth Factor and Paraoxonase-1 Enzyme Activity in rat with Non-Alcohol-Fatty Liver

نویسندگان [English]

  • ghasem masodzade 1
  • alireza barari 2
  • Asieh AbbasiDaloii 3
  • parvin farzanegi 4
1 PhD Student, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2 Associate Professor, Department of Sport Physiology , Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
3 Assistant Professor, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
4 Associate Professor, Department of Sport Physiology, sari Branch, Islamic Azad University, sari,Iran
چکیده [English]

Introduction: Non-alcoholic fatty liver is a fatty liver accumulation that increases the risk of cardiovascular disease, liver carcinoma and diabetes, and physical exercises can possibly reduce liver fat. The purpose of this study was to investigate the effect of eight weeks of aerobic training on high and moderate levels on serum levels of FGF-21 and PON-1 in non-alcoholic fatty liver.
Materials and Methods: To five equal groups: 1 control(healthy); 2) control(Fatty Liver) ; 3) saline; 4) high intensity exercise; 5) moderate intensity exercises. The period of exercise trainings was performed at 8 weeks, five times a week and 45 minutes in an exercise session. Serum samples were collected 48 hours after the last exercise session and at 12- hour fasting. One-way analysis of variance and Tukey test were used at the level of P Results: The levels of FGF-21had a significant decrease in the high and moderate intensity exercise groups than the control(Fatty Liver) (P≤0.001). Also, the levels of PON-1 had a significant increase in the high and moderate intensity exercise groups than the control(Fatty Liver) (P≤0.01), but no significantly difference between the two groups was observed.
Conclusion: According to the results of this study, it seems that high and moderate intensity exercise training can decrease FGF-21 and increase paraoxonase-1 serum levels which can result in reduced risk of liver diseases in rat Nonalcoholic Fatty Liver Disease.

کلیدواژه‌ها [English]

  • fibroblast growth factor 21
  • PON1
  • Non-alcoholic Fatty Liver Disease
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