تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار، گروه تربیت بدنی، دانشگاه خیام، مشهد، ایران

2 دانشیار،گروه فیزیولوژی ورزشی، دانشگاه فردوسی مشهد.ایران

چکیده

زمینه و هدف  مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود.
مواد و روش‌ها 42 مرد با نارسایی قلبی، نمونه‌گیری در دسترس انتخاب، به سه گروه مساوی (14 نفر) تمرین هوازی تداومی، تناوبی و کنترل تقسیم شدند. تمرین تداومی (شدت 45 تا 70 درصد ضربان قلب بیشینه) و هوازی تناوبی (شدت 45 تا 80 درصد ضربان قلب بیشینه با استراحت 5 تا 10 دقیقه‌ای بین هر تناوب) هشت هفته (سه روز در هفته) بود. نمونه خونی، قبل و پس از هشت هفته از آزمودنی‌ها گرفته و متغیرها به روش الایزا اندازه‌گیری شدند. داده‌ها با تحلیل کوواریانس، سطح معنی‌داری 05/0≥P تحلیل شدند.
یافته‌ها مقایسه بین گروه‌ها در سطوح E-selectin  در هر سه گروه، تفاوت معنی‌داری نشان داد. آزمون بنفرونی، در E-selectin تفاوت معنی‌داری بین گروه هوازی تناوبی و کنترل (0/005=P) و بین هوازی تداومی و کنترل (0/006=P) و P-selectin تفاوت معنی‌داری بین گروه هوازی تناوبی و کنترل (0/032=P) نشان داد ولی بین گروه هوازی تداومی و کنترل (0/083=P)، تغییر معنی‌داری مشاهده نشد. تفاوت معنی‌داری در متغیر‌های مورد مطالعه در دو گروه هوازی تناوبی و تداومی مشاهده نشد.
نتیجه‌گیری تمرین هوازی با کاهش سطوح مولکول‌های چسبان، احتمالاً نقش مؤثری در پیشگیری و کنترل بیماری‌های قلبی- عروقی مردانی که مبتلا به نارسایی قلبی هستند دارد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Changes of serum E-selectin and P-selectin in men with heart failure after eight weeks of continuous and intermittent aerobic exercise

نویسندگان [English]

  • Ladan Hosseini Abrishami 1
  • Seyed Mahmud Hejazi 1
  • Amir Rashid Lamir 2
1 Assistant Professor, Department of Physical Education, Khayyam University, Mashhad, Iran
2 2. Associate professor, Department of Exercise Physiology, Ferdosi University, Mashhad, Iran
چکیده [English]

Introduction: Adhesive molecules are cellular markers that identify the process of atherosclerotic plaque formation in the endothelial wall of arteries. The aim was evaluation of changes in E-selectin and P-selectin in men with heart failure after eight weeks of continuous and intermittent aerobic exercise.
Materials and Methods: 42 men with heart failure were selected by sampling method as volunteers and were divided into three equal groups (14 subjects) continuous aerobic, intermittent aerobic exercises and control groups. Continuous training (45-70% of Maximum Heart Rate) and intermittent training (45-80% of MHR with 5-10 minutes rest between each period) were done for 8 weeks (three days a week). Fasting blood samples were taken from all subjects before and after  eight weeks of aerobic exercise and adhesion molecules were measured by ELISA method. Data were analyzed by ANCOVA at significance levels of P<0.05.
Results: Comparison of the groups with covariance analysis showed that the levels of E-selectin (P=0.002) and P-selectin (P=0.022) levels was significant in all three groups. The Bonferroni test showed, There was a significant difference between the intermittent and control (P=0.005) and between continuous and control groups (P=0.006) at the level of Eselectin and the intermittent aerobic and control groups (P=0.032) at Pselectin level, However, there was no significant change despite a decrease between the control and continuing aerobic (P=0.083) in Pselecteine. Also, there was no significant difference in the studied variables in both intermittent and continuous aerobic groups.
Conclusion: Aerobic exercise with reducing levels of adhesion molecules may play an important role in the prevention and control of cardiovascular diseases in men with heart failure. 

کلیدواژه‌ها [English]

  • E-selectin
  • P-selectin
  • Exercise
  • Heart Failure
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