تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی

حسینی ابریشمی, لادن; حجازی, سید محمود; رشیدلمیر, امیر

نوع مقاله : مقاله پژوهشی

نویسندگان

¹ استادیار، گروه تربیت بدنی، دانشگاه خیام، مشهد، ایران

² دانشیار،گروه فیزیولوژی ورزشی، دانشگاه فردوسی مشهد.ایران

چکیده

زمینه و هدف مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود.
مواد و روش‌ها 42 مرد با نارسایی قلبی، نمونه‌گیری در دسترس انتخاب، به سه گروه مساوی (14 نفر) تمرین هوازی تداومی، تناوبی و کنترل تقسیم شدند. تمرین تداومی (شدت 45 تا 70 درصد ضربان قلب بیشینه) و هوازی تناوبی (شدت 45 تا 80 درصد ضربان قلب بیشینه با استراحت 5 تا 10 دقیقه‌ای بین هر تناوب) هشت هفته (سه روز در هفته) بود. نمونه خونی، قبل و پس از هشت هفته از آزمودنی‌ها گرفته و متغیرها به روش الایزا اندازه‌گیری شدند. داده‌ها با تحلیل کوواریانس، سطح معنی‌داری 05/0≥P تحلیل شدند.
یافته‌ها مقایسه بین گروه‌ها در سطوح E-selectin در هر سه گروه، تفاوت معنی‌داری نشان داد. آزمون بنفرونی، در E-selectin تفاوت معنی‌داری بین گروه هوازی تناوبی و کنترل (0/005=P) و بین هوازی تداومی و کنترل (0/006=P) و P-selectin تفاوت معنی‌داری بین گروه هوازی تناوبی و کنترل (0/032=P) نشان داد ولی بین گروه هوازی تداومی و کنترل (0/083=P)، تغییر معنی‌داری مشاهده نشد. تفاوت معنی‌داری در متغیر‌های مورد مطالعه در دو گروه هوازی تناوبی و تداومی مشاهده نشد.
نتیجه‌گیری تمرین هوازی با کاهش سطوح مولکول‌های چسبان، احتمالاً نقش مؤثری در پیشگیری و کنترل بیماری‌های قلبی- عروقی مردانی که مبتلا به نارسایی قلبی هستند دارد.

کلیدواژه‌ها

موضوعات

فیزیولوژی ورزشی

عنوان مقاله [English]

Changes of serum E-selectin and P-selectin in men with heart failure after eight weeks of continuous and intermittent aerobic exercise

نویسندگان [English]

Ladan Hosseini Abrishami ¹
Seyed Mahmud Hejazi ¹
Amir Rashid Lamir ²

¹ Assistant Professor, Department of Physical Education, Khayyam University, Mashhad, Iran

² 2. Associate professor, Department of Exercise Physiology, Ferdosi University, Mashhad, Iran

چکیده [English]

Introduction: Adhesive molecules are cellular markers that identify the process of atherosclerotic plaque formation in the endothelial wall of arteries. The aim was evaluation of changes in E-selectin and P-selectin in men with heart failure after eight weeks of continuous and intermittent aerobic exercise.
Materials and Methods: 42 men with heart failure were selected by sampling method as volunteers and were divided into three equal groups (14 subjects) continuous aerobic, intermittent aerobic exercises and control groups. Continuous training (45-70% of Maximum Heart Rate) and intermittent training (45-80% of MHR with 5-10 minutes rest between each period) were done for 8 weeks (three days a week). Fasting blood samples were taken from all subjects before and after eight weeks of aerobic exercise and adhesion molecules were measured by ELISA method. Data were analyzed by ANCOVA at significance levels of P<0.05.
Results: Comparison of the groups with covariance analysis showed that the levels of E-selectin (P=0.002) and P-selectin (P=0.022) levels was significant in all three groups. The Bonferroni test showed, There was a significant difference between the intermittent and control (P=0.005) and between continuous and control groups (P=0.006) at the level of Eselectin and the intermittent aerobic and control groups (P=0.032) at Pselectin level, However, there was no significant change despite a decrease between the control and continuing aerobic (P=0.083) in Pselecteine. Also, there was no significant difference in the studied variables in both intermittent and continuous aerobic groups.
Conclusion: Aerobic exercise with reducing levels of adhesion molecules may play an important role in the prevention and control of cardiovascular diseases in men with heart failure.

کلیدواژه‌ها [English]

E-selectin
P-selectin
Exercise
Heart Failure

مراجع

[1]. kardooni A. Effect of atorvastatin on endothelial function of patients with diastolic heart failure and normal coronary angiography. Doctoral Thesis, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Faculty of Medicine.2015; [Persian].

[2]. Pontiroli AE, Pizzocri P, Koprivec D, Vedani P, Marchi M, Arcelloni C, et al. Body Weight and Glucose Metabolism have a Different Effect on Circulating Levels of ICAM-1, Eselectin, and Endothelin-1 in Humans. Eur J Endocrinol. 2004; 150(2): 195-200.

[3]. Libby P. History of Discovery: Inflammation in Atherosclerosis. Arterioscler Thromb Vasc Biol. .2012; 32(9): 2045–2051.

[4]. Tofighi AA, ASEMI A, Hedarzade A. Relationship between BMI and Blood CRP and Fibrinogen in Obese, Thin and Normal Weight among Girl Students. Qom Univ Med Sci J 2012; 6: 82-7. [Persian].

[5]. Mohammadi Dah cheshmeh M. The effect of 8 weeks of high intensity exercise on elevated levels of Selectin-E and RBC indexes in cardiovascular patients. Master's thesis of Shahid Beheshti University, Faculty of Physical Education and Sport Sciences. 1395. Page 4. [Persian].

[6]. O'Malley T, Ludlam CA, Riemermsa RA, Fox KA. Early increase in levels of soluble inter-cellular adhesion molecule-1 (sICAM-1); potential risk factor for the acute coronary syndromes. Eur Heart J. 2001; 22(14):1226-34.

[7]. Mogharnasi M, Gaeini A, Javadi E, Kordi M, Ravasi A, Sheikholeslami Vatani D. The effect of endurance training on inflammatory biomarkers and lipid profiles in wistar rats. Wjss 2009; 2(2): 82-9.

[8]. Wilund KR. Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease? Clin Sci (Lond) 2007; 112(11): 543-55.

[9]. Aksoy S, Findikoglu G, Ardic F, Rota S, Dursunoglo D. Effect of 10-Week Supervised Moderate –Intermittent vs. Continuous Aerobic Exercise Programs on Vascular Adhesion Molecules in Patients with Heart Failure. American Journal of Physical Medicine and Rehabilitation 2015.

[10]. Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, et al. Physical Activity and Public Health. A Recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995; 273(5):402-7.

[11]. AACVPR. Cardiac Rehabilitation Resource Manual. Chicago, IL. Human Kinetics, 2006; 142-147.

[12]. Palmefors H, DuttaRoy S, Rundqvist B, Börjesson M. The Effect of Physical Activity or Exercise on Key Biomarkers in Atherosclerosis-a Systematic review. Atherosclerosis. 2014; 235(1):150-61.

[13]. Hejazi SM, Hosseini Abrishami L, Ashkanifar M. The Impact of Aerobic Selected Exercises on some of the Inflammatory Cardiovascular Factors in Type II Diabetics. Adv Environ Biol. 2014; 8(9), 357-362.

[14]. Jalaly L, Sharifi G, Faramarzi M, Nematolahi A, Rafieianakopaei M, Amiri M, et al. Compersion of the Effects of Crataegus Oxyacantha Extract, Aerobic Exercise and their Combination on the Serum Leves of ICAM-1 and ESelectin in Patients with Stable Angina Pectoris. Daru.2015; 23:54.

[15]. Ahmadizad S, Maleki M, Naderi N, Rahmani H, Noori HA, Salimian M, Lotfian S. Comparison of the effects of 8 weeks of high intensity interval training and continuous training on P-selectin expression and platelet indices in cardiovascular disease. Physiology of exercise and physical activity 2016; 17:1355-1364. [Persian].

[16]. Moradgholi E, Jafari M, Fathei M, Hejazi K. The Effect of High-Intensity Interval Training on E-Selectin and P- Selectin in Obese Women. Iranian Journal of Endocrinology and Metabolism. 2016; Vol 18(4):279-287.

[17]. Rahmani H, Ahmadi Zad S, Rouhani H, Nouri Habashi Ar, Mohammadi DehCheshmeh M. Acute effect of continuous and periodic activity on plasma levels of selcetin and white blood cell indices in patients with coronary artery disease. Sport physiology.2017, 35: 35-48. [Persian].

[18]. Byrkjeland R, Njerve IU, Arnesen H, Seljeflot I, Solheim S. Reduced Endothelial Activation after Exercise is Associated with Improved HbA1c in Patients with type 2 Diabetes and Coronary Artery Disease. Diab Vasc Dis Res, 2017; 14(2):94-103.

[19]. Freidenreich DJ, Volek JS. Immune responses to resistance exercise. Exerc Immunol Rev 2012; 18: 8-41.

[20]. Pahlavan Yali M, Hojjati Zidashti Z. Effect of 8-week Aerobic Exercise Program on Nutritional Disorders and Body Composition in Non-athlete female Students of University of Meical Sciences Gilan, Iran. Qom University of Medical Sciences Journal. 2016 ;10 (2):53-59.

[21]. Vaziri ND. Causal Link between Oxidative Stress, Inflammation, and Hypertension. Iran J Kidney Dis. 2008; 2(1):1-10.

[22]. Ribeiro F, Alves A.J, Duarte J.A, Oliveira J. Is Exercise Training an Effective Therapy Targeting Endothelial Dysfunction and Vascular Wall Inflammation? Int J Cardiol 2010; 141(3): 214-21.

[23]. Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise Training Inhibits Inflammation in Adipose Tissue Via both Suppression of Macrophage Infiltration and Acceleration of Phenotypic Switching from M1 to M2 Macrophages in High-Fat-Diet-Induced Obese Mice. Exerc Immunol Rev.2010; 16:105-18.

[24]. Ding YH, Young CN, Luan X, Li J, Rafols JA, Clark JC, McAllister JP 2nd, et al. Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion. Acta Neuropathol 2005; 109: 237-46.

مجله دانشگاه علوم پزشکی سبزوار

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی

مراجع

مراجع

دوره 27، شماره 5
آذر و دی 1399
صفحه 710-718

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی

مراجع

مراجع

دوره 27، شماره 5آذر و دی 1399صفحه 710-718

دوره 27، شماره 5
آذر و دی 1399
صفحه 710-718