نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزش دانشگاه بیرجند، بیرجند، ایران

2 دانشیار فیزیولوژی ورزش، دانشگاه بیرجند، بیرجند، ایران

3 استادیار فیزیولوژی، دانشگاه علوم پزشکی سبزوار، ایران

4 دانشیار بیوشیمی، مرکز تحقیقات سلولی و مولکولی غدد درون ریز، پژوهشکدة علوم غدد درون‌ریز و متابولیسم دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

چکیده

فعالیت بدنی بعنوان یک راهکار درمانی در نوروپاتی دیابتی در حال افزایش است. هدف این تحقیق بررسی تاثیر تمرین‌استقامتی بر سطوح سوپراکساید‌دیسموتاز (SOD) ، کاتالاز (CAT) و درد در بخش حسی نخاع موش‌های صحرایی دیابتی مبتلا به نوروپاتی بود.
نمونه تحقیق 40 سر موش صحرایی 10 هفته‌ای با دامنه وزنی 260-230 گرم بود. ابتدا 30 سر موش، با تزریق درون صفاقی استرپتوزوتوسین (45 میلی‌گرم/کیلوگرم در بافر سیترات،5/4 pH:) دیابتی شدند و پس از اطمینان از ایجاد نوروپاتی دیابتی توسط آزمون‌های فون‌فری و هات‌پلیت، به‌طور تصادفی در سه گروه تمرین تداومی، تمرین تناوبی و کنترل نوروپاتی قرار گرفتند. 10 سر موش نیز در گروه کنترل سالم قرار گرفتند. پروتکل تمرینی شامل شش هفته تمرین هوازی بود که با شدت 70-60 درصد حداکثر‌اکسیژن‌مصرفی روی نوارگردان انجام شد. 48 ساعت پس‌از آخرین جلسه تمرینی، از بخش حسی نخاع نمونه‌برداری شد. آنالیز داده‌ها با استفاده از آزمون‌های آنالیز واریانس یکراهه انجام شد (P

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of continuous and interval endurance training on superoxide dismutase and catalase activity in sensoty roots of spinal cord in diabetic neuropathic rats

نویسندگان [English]

  • hasan parsa shkooh 1
  • Marziyeh Saghebjoo 2
  • Samad Nazemi 3
  • Mehdi Hedayati 4

1 Ph.D. Student in Exercise Physiology, University of Birjand, Birjand, Iran

2 Associate Professor in Exercise Physiology, University of Birjand, Birjand, Iran

3 Assistant Professor in Physiology, Sabzevar University of Medical Sciences, Sabzevar, Iran

4 Associate Professor in Biochemistry, Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده [English]

The physical activity as a therapeutic tool is rapidly growing in the diabetic neuropathy. The aim of this study was to evaluate the effect of six weeks endurance training on the; superoxide dismutase (SOD), catalase (CAT), and pain in sensoty roots of spinal cord of rats with diabetic neuropathy. fourty rats (10 w; 230- 260 g) were study sample. Thirty rats, received interperitoneal injection of Sterptozotocin (STZ) solution (45 mg/kg, pH=4.5). Rats ranodmly assigned to three groups: diabetic continous training, diabetic interval training, diabetic control. ten rats were assigned in healthy control group. Training protocol was a six weeks aerobic training with 60- 70% VO2max treadmill run. 48 h after the last training session, the sensory part of spinal cord sampled. Data Analysed with Oneway Analysis of variance test (P

کلیدواژه‌ها [English]

  • Continous Endurance Exercise
  • Interval Endurance Exercise
  • Diabetic Neuropathy
  • Superoxide Dismutase
  • Catalase
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