نوع مقاله : مروری

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکدة تربیت بدنی، دانشگاه مازندران

2 مازندران- پردیس دانشگاه- دانشکده تربیت بدنی و علوم ورزشی

3 دانشگاه علوم پزشکی تهران

چکیده

هدف: این پژوهش با هدف مرور سیستماتیک و فراتحلیل مطالعات انجام گرفته در زمینه اثربخشی تمرینات هوازی و مقاومتی بر اتساع عروقی وابسته به جریان خون انجام پذیرفت.
روش: جهت انجام پژوهش حاضر، اتساع عروقی وابسته به جریان خون به عنوان شاخصی معتبر برای عملکرد اندوتلیال عروق انتخاب گردید. جستجو در پایگاههای اطلاعاتی Pubmed، sciencedirect، Scopus، Web of science، SID، Magiran و google Scholar با کلمات کلیدی مشخص شده بین مقالاتی که در سالهای 1986 تا 2016 به زبان‌های فارسی و انگلیسی منتشر شده بودند، انجام پذیرفت. بعد از غربالگری اولیه، بررسی متن کامل و ارزیابی نقادانه مطالعات، مقالاتی که معیارهای ورود به پژوهش را داشتند مورد آنالیز قرار گرفتند.
یافته‌ها: از تعداد 1562 مقاله‌ای که مورد ارزیابی قرار گرفتند، 23 مطالعه معیارهای ورود به مرور سیستماتیک را کسب کردند. از بین مقالات وارد شده، تعداد 14 مطالعه که شامل 17 کارآزمایی با معیارهای ورود به فراتحلیل بود مورد آنالیز قرار گرفت. نتایج متاآنالیز مطالعات نشان داد که روش‌های مختلف تمرینی می‌تواند موجب بهبود شاخص اتساع عروقی وابسته به جریان خون در آزمودنی‌های سالم (SMD= 0/84, 95 % CI 0/55–1/13, p=0/001) و افراد مبتلا به بیماری شریان کرونر (SMD= 0/49, 95 % CI 0/30–0/68, p=0/001) گردد. اگرچه اندازه اثر بدست آمده برای ورزش‌های مختلف با هم متفاوت است اما باتوجه به تعداد پایین مطالعات، نمی‌توان در مورد برتری یک روش تمرینی اظهارنظر قطعی نمود.
نتیجه گیری: تمرینات ورزشی می‌تواند در بهبود عملکرد اندوتلیال عروق مؤثر باشد اگرچه هنوز در این زمینه نیاز به مطالعاتی با کیفیت بالا و حجم نمونه کافی احساس می‌شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Systematic review and analysis of the effects of adaptation with aerobic and resistance training on blood flow-dependent dilation

نویسندگان [English]

  • Ozra Ahmadi 1
  • Valiollah Dabidiroshan 2

1 College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran, Babolsar, Iran

2 College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran, Babolsar, Iran

چکیده [English]

Aim: The aim of this paper is to use a systematic review and meta-analysis to analyze the effectiveness of aerobic and resistance training on blood Flow mediated dilation
Methods: In this study, flow mediated dilation was selected as valid index for vascular endothelial function. Search was done in databases PubMed, science direct, Scopus, Web of science, SID, Magiran and google Scholar with specified keywords among articles that were published in the years 1986 to 2016 both in Persian and English. After initial screening, full text search and critical appraisal, studies which pass the inclusion criteria were analyzed.
Results: From a total of 1562 articles that were analyzed, 23 received the study inclusion criteria for the systematic review. 14 study, which included 17 trials with meta-analysis inclusion criteria were analyzed. The results of the meta-analysis of studies showed that exercise can improve Flow mediated dilation in healthy subjects (SMD= 0/84, 95 % CI 0/55–1/13, p=0/001) and patients with coronary artery disease (SMD= 0/49, 95 % CI 0/30–0/68, p=0/001). Although the effect size obtained for different sports are different, but considering the low number of studies, we cannot make an absolute statement about the superiority of one method of training.
Conclusion: The exercise can be effective in improving endothelial function, although still high-quality research studies with sufficient sample size is needed.

کلیدواژه‌ها [English]

  • Endothelial function
  • Flow mediated dilation
  • Exercise
  • Cardiovascular disease
[1].   WHO. The global burden of disease: 2004 update. World Health Organization. 2008.
[2].   ZN H. Prevalence of coronary artery disease risk factors in Iran: A population based survey. Cardiovascular disorder. 2007; 7:32.
[3].   Davignon J, Ganz P. Role of Endothelial Dysfunction in Atherosclerosis. Circulation. 2004; 109(23 suppl 1):III-27-III-32.[1][2]
[4].   Verma S, Anderson TJ. Fundamentals of endothelial function for the clinical cardiologist. Circulation. 2002; 105(5):546-9.
[5].   Inaba Y, Chen JA, Bergmann SR. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. The international journal of cardiovascular imaging. 2010; 26(6):631-40.
[6].   Charakida M, Masi S, Luscher TF, Kastelein JJ, Deanfield JE. Assessment of atherosclerosis: the role of flow-mediated dilatation. Eur Heart J. 2010; 31(23):2854-61.
[7].   Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clinical science (London, England : 1979). 2011; 120(1):13-23.
[8].   Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002; 39(2):257-65.
[9].   Farahati S AHSR, Bijeh N, Mahjoob O The effect of aerobic exercising on plasma nitric oxide level and vessel endothelium function in postmenopausal women Razi Journal of Medical Sciences. 2014; 20(115):78-88.
[10].Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension (Dallas, Tex : 1979). 2011; 57(3):363-9.
[11].Di Francescomarino S, Sciartilli A, Di Valerio V, Di Baldassarre A, Gallina S. The effect of physical exercise on endothelial function. Sports medicine (Auckland, NZ). 2009; 39(10):797-812.
[12].Green DJ, Walsh JH, Maiorana A, Burke V, Taylor RR, O'Driscoll JG. Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training. Journal of applied physiology (Bethesda, Md : 1985). 2004; 97(2):749-55; discussion 8.
[13].Miyachi M. Effects of resistance training on arterial stiffness: a meta-analysis. Br J Sports Med. 2013; 47(6):393-6.
[14].Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training. Journal of applied physiology (Bethesda, Md : 1985). 2007; 103(5):1655-61.
[15].Montero D, Roberts CK, Vinet A. Effect of aerobic exercise training on arterial stiffness in obese populations : a systematic review and meta-analysis. Sports medicine (Auckland, NZ). 2014; 44(6):833-43.
[16].Higgins JPT GS, editors. Cochrane handbook for systematic reviews of interventions Version 5.1.0. The Cochrane Collaboration. 2011.
[17].Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339.
[18].Downs S H BN. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998; 52.
[19].Okamoto T, Masuhara M, Ikuta K. Effects of muscle contraction timing during resistance training on vascular function. Journal of Human Hypertension. 2009; 23(7):470-8.
[20].Vona M, Codeluppi GM, Iannino T, Ferrari E, Bogousslavsky J, von Segesser LK. Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction. Circulation. 2009; 119(12):1601-8.
[21].Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, et al. Exercise training enhances endothelial function in young men. Journal of the American College of Cardiology. 1999; 33(5):1379-85.
[22].Rakobowchuk M, McGowan CL, de Groot PC, Hartman JW, Phillips SM, MacDonald MJ. Endothelial function of young healthy males following whole body resistance training. Journal of Applied Physiology. 2005; 98(6):2185-90.
[23].Casey DP, Pierce GL, Howe KS, Mering MC, Braith RW. Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women. Eur J Appl Physiol. 2007; 100(4):403-8.
[24].Okamoto T, Masuhara M, Ikuta K. Effects of low-intensity resistance training with slow lifting and lowering on vascular function. J Hum Hypertens. 2008; 22(7):509-11.
[25].Lippincott MF, Desai A, Zalos G, Carlow A, De Jesus J, Blum A, et al. Predictors of Endothelial Function in Employees With Sedentary Occupations in a Worksite Exercise Program. The American Journal of Cardiology. 2008; 102(7):820-4.
[26].Okamoto T, Masuhara M, Ikuta K. Effect of low-intensity resistance training on arterial function. European Journal of Applied Physiology. 2011;111(5):743-8.
[27].Schaun MI, Dipp T, Rossato JD, Wilhelm EN, Pinto R, Rech A, et al. The effects of periodized concurrent and aerobic training on oxidative stress parameters, endothelial function and immune response in sedentary male individuals of middle age. Cell Biochemistry and Function. 2011; 29(7):534-42.
[28].Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutrition Research. 2012; 32(10) 795-9.
[29].Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, et al. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. The American Journal of Cardiology. 2002;90(2):124-7.
[30]. Walsh JH, Bilsborough W, Maiorana A, Best M, O'Driscoll GJ, Taylor RR, et al. Exercise training improves conduit vessel function in patients with coronary artery disease. Journal of applied physiology (Bethesda, Md : 1985). 2003; 95(1):20-5.
[31].Edwards DG, Schofield RS, Lennon SL, Pierce GL, Nichols WW, Braith RW. Effect of exercise training on endothelial function in men with coronary artery disease. The American Journal of Cardiology. 2004; 93(5):617-20.
[32].Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Waugh R, Georgiades A, et al. Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial. Jama. 2005; 293(13):1626-34.
[33].Sixt S, Rastan A, Desch S, Sonnabend M, Schmidt A, Schuler G, et al. Exercise training but not rosiglitazone improves endothelial function in prediabetic patients with coronary disease. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. 2008; 15(4):473-8.
[34].Munk PS, Staal EM, Butt N, Isaksen K, Larsen AI. High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation A randomized controlled trial evaluating the relationship to endothelial function and inflammation. Am Heart J. 2009; 158(5):734-41.
[35].Desch S, Sonnabend M, Niebauer J, Sixt S, Sareban M, Eitel I, et al. Effects of physical exercise versus rosiglitazone on endothelial function in coronary artery disease patients with prediabetes. Diabetes, obesity & metabolism. 2010; 12(9):825-8.
[36]. Luk TH, Dai YL, Siu CW, Yiu KH, Chan HT, Lee SW, et al. Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial. Eur J Prev Cardiol. 2012; 19(4):830-9.
[37].Cornelissen VA, Onkelinx S, Goetschalckx K, Thomaes T, Janssens S, Fagard R, et al. Exercise-based cardiac rehabilitation improves endothelial function assessed by flow-mediated dilation but not by pulse amplitude tonometry. European Journal of Preventive Cardiology. 2014; 21(1):39-48.
[38].Conraads VM, Pattyn N, De Maeyer C, Beckers PJ, Coeckelberghs E, Cornelissen VA, et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: the SAINTEX-CAD study. Int J Cardiol. 2015; 179:203-10.
[39].Casey DP BD, Braith RW. Systemic plasma levels of nitrate/nitrite  reflect brachial flow mediated dilation responses in young men and women. Clin Exp Pharmacol Physiol. 2007; 34:1291-3.
[40].Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev. 2008; 88(3):1009-86.
[41].Higashi Y YM. Exercise and endothelial function: Role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacol Ther. 2004; 102:87-96.
[42].Q X. Role of heat shock proteins in atherosclerosis. Arterioscler Thromb Vasc Biol. 2002; 22:1547-59.
[43].Belardinelli R, Lacalaprice F, Faccenda E, Purcaro A, Perna G. Effects of short-term moderate exercise training on sexual function in male patients with chronic stable heart failure. Int J Cardiol. 2005; 101(1):83-90.
[44].Ribeiro F, Ribeiro IP, Alves AJ, do Ceu Monteiro M, Oliveira NL, Oliveira J, et al. Effects of exercise training on endothelial progenitor cells in cardiovascular disease: a systematic review. Am J Phys Med Rehabil. 2013; 92(11):1020-30.
[45].Ashor AW, Lara J, Siervo M, Celis-Morales C, Oggioni C, Jakovljevic DG, et al. Exercise Modalities and Endothelial Function: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Sports Medicine. 2015; 45(2):279-96.